Energy metabolism and lipid storage in Motor Neurone Disease

Motor neurone disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a devastating disease that causes progressive muscle weakness. MND leads to death within 3 to 5 years following diagnosis. There is no successful treatment and no cure for MND.

Evidence suggests that changes in energy metabolism and energy balance can significantly alter the course of disease in MND. Researchers at CCR are conducting studies to define systemic and tissue specific changes in metabolic processes that occur specific to MND. These studies are informing researchers and clinicians of pathophysiological processes that may impair the capacity of patients to maintain a stable body weight, retain muscle mass, and supply energy to tissues. It is expected that discoveries will improve clinical care, and inform strategies to develop treatments to slow disease progression and improve quality of life.

Chief investigators: Dr Frederik Steyn, Dr Shyuan Ngo, Professor Pamela McCombe, Dr Robert Henderson