Professor McCombe’s lab research is in the field of neuroimmunology. The lab is focused on how the immune system causes disease of the nervous system and how the immune system might contribute to recovery from damage. 

The lab is focused on multiple sclerosis (MS) and motor neurone disease with an aim to slow disease progression and improve quality of life.

An overarching theme of the lab’s research is an interest in how gender and pregnancy influence diseases of the nervous system.