N-of-1 trials - Current research

Sleep health

Several projects with the aim to improve sleep in both adults and children are currently underway:

• Melatonin for initial insomnia in stimulant-treated paediatric ADHD (Funded by NHMRC)

MyNap project contact: mynap@uq.edu.au 

• Melatonin for insomnia in Parkinson's Disease (Funded by Wesley Medical Research)

Parkinsons project contact: insompd@uq.edu.au

• Multiple Baseline Single Case Experimental Design Testing the Effects of Valerian in Chronic Insomnia

Valerian project contact: Jane Nikles uqjnikle@uq.edu.au

Making it Personal: Managing Chronic Symptoms using Insights from N-of-1 Studies

• Multiple Sclerosis
• Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Project contact: Suzanne McDonald suzanne.mcdonald@uq.edu.au

Other conditions

• A pilot series of n-of-1 randomised controlled trials to compare Pregabalin and Gabapentin for persistent neuropathic pain
• Single Patient Multiple Cross-Over Trials To Determine The Efficacy Of Pilocarpine 5mg Orally Dissolving Tablets In Relieving Dry Mouth In Patients Experiencing Xerostomia

Completed projects

• Using n-of-1 trials to determine the effectiveness of paracetamol in advanced cancer patients on opioids. (Funded by the NHMRC)
• Using single patient trials to determine the effectiveness of psycho-stimulants in end stage fatigue in cancer patients. (Funded by the NHMRC)
• N-of-1 trials of stimulants compared to placebo for traumatic brain injury in children. (Funded by Motor Accident Insurance Commission)
• A series of N-of-1 trials to assess therapeutic interchangeability of two Enalapril formulations in the treatment of hypertension, Addis Ababa, Ethiopia
• Physical Activity Promotion in Community-Dwelling Adults with Whiplash Associated Disorders: a pilot series of single case experimental designs (funded by HABS)