Jodi is a multidisciplinary researcher in the Molecular Breast Pathology Group. She has an Honours degree in biochemistry and biomedical science, and a PhD in breast cancer molecular genetics, and has conducted post-doctoral research in immunology, cancer heterogeneity, molecular pathology and molecular/cellular cancer biology.
Jodi’s research focuses on identifying new ways to improve the management of breast cancer patients with brain metastases. This multidisciplinary program of work involves identifying molecular mechanisms underlying the outgrowth of breast cancer cells in the brain, some of which may be new drug targets, or represent opportunities for drug repositioning. This requires the use of experimental models of metastatic brain tumour development and high-resolution molecular profiling of human brain metastases. She is also helping to drive a new bioimaging initiative through the RBWH and Herston Imaging Research Facility (HIRF), involving testing of a new theranostic for brain metastases from HER2+ breast cancer.
Another major area of interest is the identification of new prognostic and predictive breast cancer biomarkers; particularly for triple-negative breast cancer, which is characterised by marked inter- and intratumoural heterogeneity, exhibits variable clinical behaviour and for which there is an urgent need for new molecular-targeted therapies. Jodi works with the MBP group’s archival tumour sample cohorts to identify relationships between the expression of candidate genes/proteins, clinicopathologic features and clinical outcomes, as well as patterns of metastasis.
Jodi is a keen advocate for raising awareness about stage IV breast cancer, and regularly speaks at community events to share information about current research in the MBP group and the medical research community generally.
The National Health and Medical Research Council (NHMRC)
Cancer Council Queensland
The University of Queensland
Korinne Northwood (MBBS/PhD)
Malcolm Lim (Hons)