Apathy is a common symptom after stroke, occurring in approximately 19-55% of stroke survivors. It overlaps with depression and cognitive dysfunction, but these features are partly dissociable and the relationships between them are not well understood. Apathy appears to have a particularly strong effect on carer burden and is the strongest predictors of quality of life following stroke. It is likely that apathy, depression and cognitive impairment have adverse effects on recovery after stroke by limiting the effectiveness of rehabilitation.

This study will investigate the influence of apathy and depression on outcome 1 year after stroke. It represents the Australian arm of an international study on apathy, led by Cambridge University and Addenbrooke’s University Hospital, UK. Additionally, advanced magnetic resonance imaging (MRI) scans will be collected from eligible participants to try to separate the neuroanatomical bases of apathy, depression and impaired cognitive control.