Neurodevelopmental outcomes at 2 years following ibuprofen treatment for patent ductus arteriosus in the preterm small for gestational age newborn: potential for neuroprotection

Funding: Metro North Hospital and Health Services

Chief Investigators: Pienaar J, Wixey J, Lai M, Colditz P, Wright I, Oei J.

Small for gestational age (SGA) is a baby that does not grow well inside the womb – this is usually due to fetal growth restriction (FGR). Brain impairment in SGA newborns is a major cause of death and disability worldwide – with no treatments available for these babies. Ibuprofen has been linked to better brain outcomes following its use for heart conditions in preterm babies. We plan a retrospective study of neurodevelopmental outcomes in preterm SGA infants that have or have not received ibuprofen to treat heart conditions. If results suggest benefit, we can progress to a clinical trial of ibuprofen in SGA infants to improve brain outcomes.