Almost one third of epilepsy patients have to endure a “medication odyssey” in the hope of finding an effective treatment. To shorten or alleviate this burden, brain organoids can created from pluripotent stem cells derived from the blood cells of epilepsy patients that are drug responsive or drug refractory.

We next examine the brain organoid activity patterns to discover drugs and drug combinations that are effective in treating the drug resistant patients (using the responsive ones as controls). We envisage that this unique approach will dramatically shorten the “medication odyssey” that epilepsy patients have to endure without finding an effective treatment.

This project is in collaboration with Prof Ernst Wolvetang from The University of Queensland Australian Institute for Bioengineering and Nanotechnology.

This project is being undertaken in the Vadlamudi Group.