M1: Mental Illness and the Immune System

The M1 study aims to investigate if the immune system may be involved in the development of psychotic mental illness. This will be done by measuring levels of antibodies against a receptor in the brain, the m1 muscarinic acetylcholine receptor (m1AChR), in people who are experiencing their first episode of psychotic mental illness. It will be investigated whether m1AChR antibodies are related to particular symptoms of psychotic mental illness and whether their presence at onset of illness is related to the development of chronic psychotic illness.

Chief investigators: A/Prof James Scott, A/Prof Judith Greer, Dr Stefan Blum, A/Prof Gail Robinson, Dr Subramanian Purushothaman, Mr Alexander Ryan