Understanding neuropathology in fetal growth restricted newborns with Dr Kirat Chand

Kirat Chand is a postdoctoral researcher in the Perinatal Research Centre, based at UQCCR. His field of expertise include the establishment of synaptic connections and cellular changes associated with injury in the neonatal brain. His current work investigates the evolution of brain injury in fetal growth restricted (FGR) newborns with a particular interest in understanding mechanisms to develop better detection and treatment strategies for this vulnerable population.
FGR is the second leading cause of perinatal morbidity and mortality, with around 32 million babies born FGR globally each year. FGR is commonly caused by placental insufficiency, resulting in an inadequate supply of oxygen and nutrients to the fetus. The brain is particularly vulnerable to FGR conditions and adverse outcomes in these children range from mild learning difficulties to neurobehavioral issues, and in some cases cerebral palsy. Currently there are no interventions available to protect the FGR brain. Using the pre-clinical pig model, we can examine pathology of the newborn brain. We have identified neuroinflammation as playing a critical role in exacerbating brain injury in FGR newborns and may serve as a therapeutic target.