Professor Hayden Homer
Theme Leader for Fertility
Professor, Christopher Chen Chair in Reproductive Medicine
UQ Centre for Clinical Research
Book Chapters
Zhou, Chenxi, Ye, Yunan and Homer, Hayden (2024). Using FRET to Define Cdk1-Dependent Ordering of Events During Exit from Second Meiotic M-Phase in Oocytes. Methods in Molecular Biology. (pp. 99-114) New York, NY: Springer US. doi: 10.1007/978-1-0716-4236-8_9
Greaney, Jessica, Wei, Zhe and Homer, Hayden (2018). Immunofluorescence staining of K-fibers in mouse oocytes using cold fixation. Mouse oocyte development: methods and protocols. (pp. 77-87) edited by Marie-Hélène Verlhac and Marie-Emilie Terret. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-8603-3_9
Homer, Hayden (2013). Getting into and out of oocyte maturation. Biology and pathology of the oocyte: role in fertility, medicine and nuclear reprograming . (pp. 119-141) New York, United States: Cambridge University Press. doi: 10.1017/CBO9781139135030.012
Homer, Hayden (2011). Evaluating spindle assembly checkpoint competence in mouse oocytes using immunoblotting. Cell cycle checkpoints. (pp. 33-45) New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-273-1_4
Journal Articles
Ho, Wing-Hong Jonathan, Marinova, Maria B, Listijono, Dave R, Bertoldo, Michael J, Richani, Dulama, Kim, Lynn-Jee, Brown, Amelia, Riepsamen, Angelique H, Cabot, Safaa, Frost, Emily R, Bustamante, Sonia, Zhong, Ling, Selesniemi, Kaisa, Wong, Derek, Madawala, Romanthi, Marchante, Maria, Goss, Dale M, Li, Catherine, Araki, Toshiyuki, Livingston, David J, Turner, Nigel, Sinclair, David A, Walters, Kirsty A, Homer, Hayden A, Gilchrist, Robert B and Wu, Lindsay E (2024). Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome. EMBO Molecular Medicine, 16 (10), 2583-2618. doi: 10.1038/s44321-024-00119-w
HOMER, Hayden A. (2024). Understanding oocyte ageing. Minerva Obstetrics and Gynecology, 76 (3), 284-292. doi: 10.23736/s2724-606x.24.05343-0
Ye, Yunan and Homer, Hayden Anthony (2024). A surge in cytoplasmic viscosity triggers nuclear remodeling required for Dux silencing and pre-implantation embryo development. Cell Reports, 43 (3) 113917, 113917. doi: 10.1016/j.celrep.2024.113917
Moss, Katrina M., Doust, Jenny, Copp, Tessa, Homer, Hayden and Mishra, Gita D. (2023). Fertility treatment pathways and births for women with and without polycystic ovary syndrome—a retrospective population linked data study. Fertility and Sterility, 121 (2), 314-322. doi: 10.1016/j.fertnstert.2023.11.008
Homer, Hayden Anthony (2023). Effects of endometriosis on in vitro fertilisation – Myth or reality?. Australian and New Zealand Journal of Obstetrics and Gynaecology, 63 (1), 3-5. doi: 10.1111/ajo.13643
Ye, Yunan and Homer, Hayden A. (2022). Two‐step nuclear centring by competing microtubule‐ and actin‐based mechanisms in 2‐cell mouse embryos. EMBO reports, 23 (11) e55251, 1-18. doi: 10.15252/embr.202255251
Zhou, Chenxi and Homer, Hayden A. (2022). The oocyte spindle midzone pauses Cdk1 inactivation during fertilization to enable male pronuclear formation and embryo development. Cell Reports, 39 (5) 110789, 110789. doi: 10.1016/j.celrep.2022.110789
Moss, K. M., Doust, J., Homer, H., Rowlands, I. J., Hockey, R. and Mishra, G. D. (2021). Delayed diagnosis of endometriosis disadvantages women in ART: a retrospective population linked data study. Human Reproduction, 36 (12), 3074-3082. doi: 10.1093/humrep/deab216
Greaney, Jessica, Subramanian, Goutham, Ye, Yunan and Homer, Hayden (2021). Isolation and in vitro culture of mouse oocytes. bio-protocol, 11 (15) e4104, e4104. doi: 10.21769/bioprotoc.4104
Homer, Hayden Anthony (2021). Understanding oocyte ageing: can we influence the process as clinicians?. Current Opinion in Obstetrics and Gynecology, 33 (3), 218-224. doi: 10.1097/GCO.0000000000000708
Homer, Hayden Anthony (2021). Website advertising of IVF add‐ons: Does PGT‐A live up to its billing?. Australian and New Zealand Journal of Obstetrics and Gynaecology, 61 (3), 328-330. doi: 10.1111/ajo.13366
Ho, Uda Y., Feng, Chun-Wei Allen, Yeap, Yvonne Y., Bain, Amanda L., Wei, Zhe, Shohayeb, Belal, Reichelt, Melissa E., Homer, Hayden, Khanna, Kum Kum, Bowles, Josephine and Ng, Dominic C. H. (2021). WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. Communications Biology, 4 (1) 645, 1-14. doi: 10.1038/s42003-021-02171-5
Homer, Hayden A. (2021). Senataxin: a new guardian of the female germline important for delaying ovarian aging. Frontiers in Genetics, 12 647996, 1-9. doi: 10.3389/fgene.2021.647996
Subramanian, G. N., Lavin, M. and Homer, H. A. (2020). Premature ovarian ageing following heterozygous loss of Senataxin. Molecular Human Reproduction, 27 (2) gaaa080. doi: 10.1093/molehr/gaaa080
Venables, Ashley, Wong, Wilbert, Way, Mandy and Homer, Hayden Anthony (2020). Thyroid autoimmunity and IVF/ICSI outcomes in euthyroid women: a systematic review and meta-analysis. Reproductive Biology and Endocrinology, 18 (1) 120, 120. doi: 10.1186/s12958-020-00671-3
Iljas, Juvita D., Wei, Zhe and Homer, Hayden A. (2020). Sirt1 sustains female fertility by slowing age‐related decline in oocyte quality required for post‐fertilization embryo development. Aging Cell, 19 (9) e13204, e13204. doi: 10.1111/acel.13204
Wei, Zhe, Greaney, Jessica, Loh, Wei-Guo Nicholas and Homer, Hayden Anthony (2020). Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry. Nature Communications, 11 (1) 3393, 3393. doi: 10.1038/s41467-020-17088-6
Gleicher, N., Albertini, D. F., Barad, D. H., Homer, H., Modi, D., Murtinger, M., Patrizio, P., Orvieto, R., Takahashi, S., Weghofer, A., Ziebe, S., Noyes, N. and for the International Do No Harm Group in IVF (IDNHG-IVF) (2020). The 2019 PGDIS position statement on transfer of mosaic embryos within a context of new information on PGT-A. Reproductive Biology and Endocrinology, 18 (1) 57. doi: 10.1186/s12958-020-00616-w
Subramanian, Goutham Narayanan, Greaney, Jessica, Wei, Zhe, Becherel, Olivier, Lavin, Martin and Homer, Hayden Anthony (2020). Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis. Journal of Cell Biology, 219 (4) e201907213. doi: 10.1083/jcb.201907213
Iljas, Juvita D. and Homer, Hayden A. (2020). Sirt3 is dispensable for oocyte quality and female fertility in lean and obese mice. FASEB Journal, 34 (5), 6641-6653. doi: 10.1096/fj.202000153R
Bertoldo, Michael J., Listijono, Dave R., Ho, Wing-Hong Jonathan, Riepsamen, Angelique H., Goss, Dale M., Richani, Dulama, Jin, Xing L., Mahbub, Saabah, Campbell, Jared M., Habibalahi, Abbas, Loh, Wei-Guo Nicholas, Youngson, Neil A., Maniam, Jayanthi, Wong, Ashley S.A., Selesniemi, Kaisa, Bustamante, Sonia, Li, Catherine, Zhao, Yiqing, Marinova, Maria B., Kim, Lynn-Jee, Lau, Laurin, Wu, Rachael M., Mikolaizak, A. Stefanie, Araki, Toshiyuki, Le Couteur, David G., Turner, Nigel, Morris, Margaret J., Walters, Kirsty A., Goldys, Ewa ... Wu, Lindsay E. (2020). NAD+ repletion rescues female fertility during reproductive aging. Cell Reports, 30 (6), 1670-1681.e7. doi: 10.1016/j.celrep.2020.01.058
Homer, Hayden Anthony (2020). Reporting IVF outcomes: the devil is in the detail. Australian and New Zealand Journal of Obstetrics and Gynaecology, 60 (1), 11-14. doi: 10.1111/ajo.13118
Astbury, Pia, Subramanian, Goutham N., Greaney, Jessica, Roling, Chris, Irving, Jacqui and Homer, Hayden A. (2020). The presence of immature GV− stage oocytes during IVF/ICSI is a marker of poor oocyte quality: a pilot study. Medical Sciences, 8 (1), 4. doi: 10.3390/medsci8010004
Homer, Hayden Anthony (2020). The role of oocyte quality in explaining “unexplained” infertility. Seminars in Reproductive Medicine, 38 (01), 21-28. doi: 10.1055/s-0040-1721377
Zhou, Chenxi, Hancock, Janelle L., Khanna, Kum Kum and Homer, Hayden A. (2019). First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation. Journal of Cell Science, 132 (18) jcs233379, jcs233379. doi: 10.1242/jcs.233379
Costello, Michael, Garad, Rhonda, Hart, Roger, Homer, Hayden, Johnson, Louise, Jordan, Cailin, Mocanu, Edgar, Qiao, Jie, Rombauts, Luk, Teede, Helena J., Vanky, Eszter, Venetis, Christos and Ledger, William (2019). A review of first line infertility treatments and supporting evidence in women with polycystic ovary syndrome. Medical Sciences, 7 (9) 95, 1-10. doi: 10.3390/medsci7090095
Homer, Hayden Anthony (2019). Preimplantation genetic testing for aneuploidy (PGT-A): the biology, the technology and the clinical outcomes. Australian and New Zealand Journal of Obstetrics and Gynaecology, 59 (2), 317-324. doi: 10.1111/ajo.12960
Becherel, Olivier J., Fogel, Brent L., Zeitlin, Scott I., Samaratunga, Hemamali, Greaney, Jessica, Homer, Hayden and Lavin, Martin F. (2019). Disruption of spermatogenesis and infertility in Ataxia with Oculomotor Apraxia Type 2 (AOA2). Cerebellum, 18 (3), 448-456. doi: 10.1007/s12311-019-01012-w
Homer, Hayden Anthony (2018). Modern management of recurrent miscarriage. Australian and New Zealand Journal of Obstetrics and Gynaecology, 59 (1), 36-44. doi: 10.1111/ajo.12920
Wei, Zhe, Greaney, Jessica, Zhou, Chenxi and A. Homer, Hayden (2018). Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes. Nature Communications, 9 (1) 4029, 4029. doi: 10.1038/s41467-018-06510-9
Greaney, Jessica, Wei, Zhe and Homer, Hayden (2017). Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors. Human Reproduction Update, 24 (2), 135-161. doi: 10.1093/humupd/dmx035
Homer, Hayden, Rice, Gregory E. and Salomon, Carlos (2017). Embryo- and endometrium-derived exosomes and their potential role in assisted reproductive treatments-liquid biopsies for endometrial receptivity. Placenta, 54, 89-94. doi: 10.1016/j.placenta.2016.12.011
Riepsamen, Angelique, Wu, Lindsay, Lau, Laurin, Listijono, Dave, Ledger, William, Sinclair, David A. and Homer, Hayden (2015). Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes. PLoS One, 10 (5) e0126194, e0126194. doi: 10.1371/journal.pone.0126194
Riepsamen, Angelique, Wu, Lindsay, Lau, Laurin, Listijono, Dave, Ledger, William, Sinclair, David and Homer, Hayden (2015). Correction: Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes. PLoS One, 10 (6) e0126194, e0130058. doi: 10.1371/journal.pone.0130058
Homer, Hayden A. (2014). How separated sisters get bad connections. Cell Cycle, 13 (8), 1222-1223. doi: 10.4161/cc.28567
Riris, Solon, Webster, Philippa and Homer, Hayden (2014). Digital multiplexed mRNA analysis of functionally important genes in single human oocytes and correlation of changes in transcript levels with oocyte protein expression. Fertility and Sterility, 101 (3), 857-864. doi: 10.1016/j.fertnstert.2013.11.125
Homer, Hayden (2013). The APC/C in female mammalian meiosis I. Reproduction, 146 (2), R61-R71. doi: 10.1530/REP-13-0163
Gui, Liming and Homer, Hayden (2013). Hec1-dependent cyclin B2 stabilization regulates the G2-M transition and early prometaphase in mouse oocytes. Developmental Cell, 25 (1), 43-54. doi: 10.1016/j.devcel.2013.02.008
Riris, Solon, Cawood, Suzanne, Gui, Liming, Serhal, Paul and Homer, Hayden A. (2013). Immunofluorescence staining of spindles, chromosomes, and kinetochores in human oocytes. Methods in Molecular Biology, 957, 179-187. doi: 10.1007/978-1-62703-191-2-12
Homer, Hayden A. (2013). Preface. Methods in Molecular Biology, 957, v-vi.
Polański, Zbigniew, Homer, Hayden and Kubiak, Jacek Z. (2012). Cyclin B in mouse oocytes and embryos: Importance for human reproduction and aneuploidy. Results and Problems in Cell Differentiation, 55, 69-91. doi: 10.1007/978-3-642-30406-4-4
Gui, Liming and Homer, Hayden (2012). Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes. Development, 139 (11), 1941-1946. doi: 10.1242/dev.078352
Homer, H. (2011). New insights into the genetic regulation of homologue disjunction in mammalian oocytes. Cytogenetic and Genome Research, 133 (2-4), 209-222. doi: 10.1159/000324118
Homer, Hayden and Saridogan, Ertan (2010). Uterine artery embolization for fibroids is associated with an increased risk of miscarriage. Fertility and Sterility, 94 (1), 324-330. doi: 10.1016/j.fertnstert.2009.02.069
Homer, Hayden and Davies, Melanie (2010). The science and ethics of human admixed embryos Zarodki bȩda̧ce hybrydami ludzko-zwierzȩcymi: Aspekty naukowe i etyczne. Poloznictwo Ginekologia i Medycyna Rozrodu, 4 (1), 91-97.
Homer, Hayden, Gui, Liming and Carroll, John (2009). A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression. Science, 326 (5955), 991-994. doi: 10.1126/science.1175326
Homer, Hayden and Davies, Melanie (2009). The science and ethics of human admixed embryos. Obstetrics, Gynaecology and Reproductive Medicine, 19 (9), 235-239. doi: 10.1016/j.ogrm.2009.05.004
Homer, HA (2006). Mad2 and spindle assembly checkpoint function during meiosis I in mammalian oocytes. Histology and Histopathology, 21 (8), 873-886.
Homer, HA, McDougall, A, Levasseur, M and Herbert, M (2005). Restaging the spindle assembly checkpoint in female mammalian meiosis I. Cell Cycle, 4 (5), 650-653. doi: 10.4161/cc.4.5.1677
Homer, HA, McDougall, A, Levasseur, M, Yallop, K, Murdoch, AP and Herbert, M (2005). Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes. Genes and Development, 19 (2), 202-207. doi: 10.1101/gad.328105
Homer, HA, McDougall, A, Levasseur, M, Murdoch, AP and Herbert, M (2005). Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes. Reproduction, 130 (6), 829-843. doi: 10.1530/rep.1.00856
Homer, HA, McDougall, A, Levasseur, M, Murdoch, AP and Herbert, M (2005). RNA interference in meiosis I human oocytes: Towards an understanding of human aneuploidy. Molecular Human Reproduction, 11 (6), 397-404. doi: 10.1093/molehr/gah184
Herbert, M, Levasseur, M, Homer, H, Yallop, K, Murdoch, A and McDougall, A (2003). Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1. Nature Cell Biology, 5 (11), 1023-1025. doi: 10.1038/ncb1062
Homer, HA, Li, TC and Cooke, ID (2000). Clinical studies without patients - Reply. Fertility and Sterility, 74 (1), 187-188. doi: 10.1016/S0015-0282(00)00589-6
Homer, HA, Li, TC and Cooke, ID (2000). The septate uterus: A review of management and reproductive outcome. Fertility and Sterility, 73 (1), 1-14. doi: 10.1016/S0015-0282(99)00480-X
Roopnarinesingh, A. J., Homer, H., Bassaw, B., Sirjusingh, A. and Roopnarinesingh, S. (1999). Obstetric hazards of maternal obesity. Journal of Obstetrics and Gynaecology, 19 (5), 474-476. doi: 10.1080/01443619964238
Bassaw, B., Roopnarinesingh, S., Roopnarinesingh, A. and Homer, H. (1998). Prevention of hypertensive disorders of pregnancy. Journal of Obstetrics and Gynaecology, 18 (2), 123-126. doi: 10.1080/01443619867830
Conference Papers
Gilchrist, Robert, Ho, Wing-Hong Jonathan, Marinova, Maria B., Listijono, Dave R., Bertoldo, Michael J., Richani, Dulama, Lynn-Jee, Kim, Brown, Amelia, Riepsamen, Angelique H., Cabot, Safaa, Bustamante, Sonia, Zhong, Ling, Selesniemi, Kaisa, Wong, Derek, Goss, Dale M., Li, Catherine, Araki, Toshiyuki, Livingston, David J., Turner, Nigel, Sinclair, David A., Walters, Kirsty A., Homer, Hayden A. and Wu, Lindsay E. (2023). Fertility Preservation During Chemotherapy Treatment by NAD+ Repletion in Mice. 12th Congress Of The Asia Pacific Initiative On Reproduction, Adelaide, SA Australia, 7-10 September 2023. Singapore: World Scientific Publishing. doi: 10.1142/s2661318223742790
MOORE, Rebecca, MOORE, David, MACARTHUR, Lauren, HOMER, Hayden, CAMERON, Sarah and BELL, Nicholas (2022). Fertility Awareness and Attitudes Among Women Embarking on a Career in Medicine. Fertility Society Of Australia And New Zealand Annual Conference, Sydney, NSW Australia, 30 July–2 August 2022. Singapore: World Scientific Publishing. doi: 10.1142/s2661318222740656
Fogel, Brent, Becherel, Olivier, Zeitlin, Scott, Samaratunga, Hemamali, Greaney, Jessica, Homer, Hayden and Lavin, Martin (2019). Disruption of spermatogenesis and infertility in Ataxia with Oculomotor Apraxia Type 2 (AOA2). 71st Annual Meeting of the American-Academy-of-Neurology (AAN), Philadelphia, PA, United States, 4-10 May 2019. Philadelphia, PA, United States: Lippincott Williams & Wilkins.
Fogel, Brent, Becherel, Olivier, Zeitlin, Scott, Samaratunga, Hemamali, Greaney, Jessica, Homer, Hayden and Lavin, Martin (2019). Disruption of spermatogenesis and infertility in Ataxia with Oculomotor Apraxia Type 2 (AOA2). AAN 71st Annual Meeting, Philadelphia, PA United States, 4-10 May 2019. Philadelphia, PA United States: Wolters Kluwer. doi: 10.1212/wnl.92.15_supplement.p4.7-003
Homer, Hayden (2017). Sirtuin-mediated regulation of oocyte quality. ESA-SRB-ANZBMS 2016 , Gold Coast Convention and Exhibition Centre, Gold Coast, Queensland, Australia, 21-24 August 2016. Chichester, West Sussex, United Kingdom : Wiley-Blackwell.
Homer, Hayden, Yazdani, Anusch, Rice, Gregory E. and Salomon, Carlos (2017). Characterization of embryo-derived exosomal miRNAs: implications on endometrial receptivity.. 64th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Orlando, FL, United States, 15-18 March 2017. Thousand Oaks, CA, United States: Sage Publications.
Homer, H. A., McDougall, A., Levasseur, M., Murdoch, A. P. and Herbert, M. (2006). Spindle assembly checkpoint dysfunction: a molecular correlate for human aneuploidy. 53rd Annual Scientific Meeting of the Society-for-Gynecologic-Investigation, Toronto Canada, Mar 22-25, 2006. BLACKWELL PUBLISHING.