Dr Bhavisha Bakrania
Research Fellow/Senior Research Officer & Research Fellow/Senior Research officer
UQ Centre for Clinical Research
Book Chapter
George, Eric M., Bakrania, Bhavisha A., Granger, Joey P. and Conrad, Kirk P. (2022). Animal models used for investigating pathophysiology of preeclampsia and identifying therapeutic targets. Chesley’s hypertensive disorders in pregnancy. (pp. 435-447) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-818417-2.00015-4
Journal Articles
McClements, Lana, Richards, Claire, Bakrania, Bhavisha, Owen, Grace, Zhand, Sareh, Huyen Phan, Thanh, Lei, Qingyu, McGrath, Kristine and Chrzanowski, Wojciech (2024). Bioprinting a placental model to study the effects of current and emerging treatments of preeclampsia. Pregnancy Hypertension, 36, 5. doi: 10.1016/j.preghy.2024.01.010
Nguyen, Tam M. T., Morwood, Holly, Bakrania, Bhavisha A., Miller, Stephanie M., Bjorkman, Stella T., Lingwood, Barbara E., Wright, Ian M. R. and Eiby, Yvonne A. (2024). Blood volume reduction due to rapid plasma loss after birth in preterm piglets. Pediatric Research. doi: 10.1038/s41390-024-03252-x
Bakrania, Bhavisha A., Spradley, Frank T. and McClements, Lana (2024). Editorial: Adverse outcomes of preeclampsia: from mother to baby, pregnancy to postpartum. Frontiers in Physiology, 15 ARTN 1394120. doi: 10.3389/fphys.2024.1394120
Forbes, Elizabeth M., Bakrania, Bhavisha A., Steane, Sarah E., Moritz, Karen M., Lingwood, Barbara E. and Eiby, Yvonne A. (2022). Expression of TRPM6 and TRPM7 in the preterm piglet heart. Frontiers in Pediatrics, 10 891722, 1-11. doi: 10.3389/fped.2022.891722
Bakrania, Bhavisha A., Palei, Ana C., Bhattarai, Umesh, Chen, Yingjie, Granger, Joey P. and Shahul, Sajid (2022). Sustained elevated circulating activin a impairs global longitudinal strain in pregnant rats: a potential mechanism for preeclampsia-related cardiac dysfunction. Cells, 11 (4) 742, 742. doi: 10.3390/cells11040742
Coats, Laura E., Bakrania, Bhavisha A., Bamrick-Fernandez, Daniel R., Ariatti, Allison M., Rawls, Adam Z., Ojeda, Norma B. and Alexander, Barbara T. (2021). Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric IUGR or cardiovascular risk induced by placental ischemia in the rat. American Journal of Physiology: Heart and Circulatory Physiology, 320 (5) ajpheart.00033.2021, H1923-H1934. doi: 10.1152/ajpheart.00033.2021
Yang, Weiwei, Li, Qinghua, Duncan, Jeremy W., Bakrania, Bhavisha A., Bradshaw, Jessica L., Granger, Joey P., Rana, Sarosh and Spradley, Frank T. (2021). Luteolin-induced vasorelaxation in uterine arteries from normal pregnant rats. Pregnancy Hypertension, 23, 11-17. doi: 10.1016/j.preghy.2020.10.008
Bakrania, Bhavisha A., George, Eric M. and Granger, Joey P. (2021). Animal models of preeclampsia: investigating pathophysiology and therapeutic targets. American Journal of Obstetrics and Gynecology, 226 (2), S973-S987. doi: 10.1016/j.ajog.2020.10.025
deMartelly, Victoria A, Dreixler, John, Tung, Avery, Mueller, Ariel, Heimberger, Sarah, Fazal, Abid A., Naseem, Heba, Lang, Roberto, Kruse, Eric, Yamat, Megan, Granger, Joey P., Bakrania, Bhavisha A., Rodriguez-Kovacs, Javier, Rana, Sarosh and Shahul, Sajid (2021). Long-term postpartum cardiac function and its association with preeclampsia. Journal of the American Heart Association, 10 (5) e018526, 1-9. doi: 10.1161/jaha.120.018526
Coats, Laura E., Bamrick-Fernandez, Daniel R., Ariatti, Allison M., Bakrania, Bhavisha A., Rawls, Adam Z., Ojeda, Norma B. and Alexander, Barbara T. (2021). Stimulation of soluble guanylate cyclase diminishes intrauterine growth restriction in a rat model of placental ischemia. AJP: Regulatory, Integrative and Comparative Physiology, 320 (2), R149-R161. doi: 10.1152/ajpregu.00234.2020
Bakrania, Bhavisha A., Spradley, Frank T., Drummond, Heather A., LaMarca, Babbette, Ryan, Michael J. and Granger, Joey P. (2020). Preeclampsia: Linking Placental Ischemia with Maternal Endothelial and Vascular Dysfunction. Comprehensive Physiology, 11 (1), 1315-1349. doi: 10.1002/cphy.c200008
Naseem, Heba, Dreixler, John, Mueller, Ariel, Tung, Avery, Dhir, Rohin, Chibber, Rachna, Fazal, Abid, Granger, Joey P., Bakrania, Bhavisha A., deMartelly, Victoria, Rana, Sarosh and Shahul, Sajid (2020). Antepartum aspirin administration reduces activin A and cardiac global longitudinal strain in preeclamptic women. Journal of the American Heart Association, 9 (12) e015997. doi: 10.1161/jaha.119.015997
Bakrania, Bhavisha A., Hall, Michael E., Shahul, Sajid and Granger, Joey P. (2019). The Reduced Uterine Perfusion Pressure (RUPP) rat model of preeclampsia exhibits impaired systolic function and global longitudinal strain during pregnancy. Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health, 18, 169-172. doi: 10.1016/j.preghy.2019.10.001
Terstappen, Fieke, Spradley, Frank T., Bakrania, Bhavisha A., Clarke, Sinead M., Joles, Jaap A., Paauw, Nina D., Garrett, Michael R., Lely, A. Titia and Sasser, Jennifer M. (2019). Prenatal Sildenafil Therapy Improves Cardiovascular Function in Fetal Growth Restricted Offspring of Dahl Salt-Sensitive Rats. Hypertension, 73 (5), 1120-1127. doi: 10.1161/hypertensionaha.118.12454
Granger, Joey P., Spradley, Frank T. and Bakrania, Bhavisha A. (2018). The Endothelin System: A Critical Player in the Pathophysiology of Preeclampsia. Current Hypertension Reports, 20 (4) 32. doi: 10.1007/s11906-018-0828-4
Bulmer, Andrew Cameron, Bakrania, Bhavisha A., Du Toit, Eugene Francois, Boon, Ai-Ching, Clark, Paul J., Powell, Lawrie W., Wagner, Karl-Heinz and Headrick, John P. (2018). Bilirubin acts as a multi-potent guardian of cardiovascular integrity: more than just a radical idea. American Journal of Physiology. Heart and Circulatory Physiology , 315 (3) ajpheart.00417.2017, H429-H447. doi: 10.1152/ajpheart.00417.2017
Bakrania, Bhavisha A., Spradley, Frank T., Satchell, Simon C., Stec, David E., Rimoldi, John M., Gadepalli, Rama S. V. and Granger, Joey P. (2018). Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells. American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 314 (3), R427-R432. doi: 10.1152/ajpregu.00370.2017
Bakrania, B., Du Toit, E. F., Ashton, K. J., Wagner, K-H., Headrick, J. P. and Bulmer, A. C. (2017). Chronically elevated bilirubin protects from cardiac reperfusion injury in the male Gunn rat. Acta Physiologica, 220 (4), 461-470. doi: 10.1111/apha.12858
Paauw, Nina D., Joles, Jaap A., Spradley, Frank T., Bakrania, Bhavisha, Zsengeller, Zsuzsanna K., Franx, Arie, Verhaar, Marianne C., Granger, Joey P. and Lely, A. Titia (2017). Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats. American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 312 (5), R664-R670. doi: 10.1152/ajpregu.00510.2016
Bakrania, Bhavisha, Duncan, Jeremy, Warrington, Junie P. and Granger, Joey P. (2017). The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia. International Journal of Molecular Sciences, 18 (3) 522, 522. doi: 10.3390/ijms18030522
Bakrania, Bhavisha, Granger, Joey P. and Harmancey, Romain (2016). Methods for the Determination of Rates of Glucose and Fatty Acid Oxidation in the Isolated Working Rat Heart. Journal of Visualized Experiments, 2016 (115) e54497. doi: 10.3791/54497
Bakrania, Bhavisha, Du Toit, Eugene F., Wagner, Karl-Heinz, Headrick, John P. and Bulmer, Andrew C. (2016). Pre- or post-ischemic bilirubin ditaurate treatment reduces oxidative tissue damage and improves cardiac function. International Journal of Cardiology, 202, 27-33. doi: 10.1016/j.ijcard.2015.08.192
Bakrania, Bhavisha, Du Toit, Eugene F., Ashton, Kevin J., Kiessling, Can J., Wagner, Karl-Heinz, Headrick, John P. and Bulmer, Andrew C. (2014). Hyperbilirubinemia modulates myocardial function, aortic ejection, and ischemic stress resistance in the Gunn rat. American Journal of Physiology: Heart and Circulatory Physiology, 307 (8), H1142-H1149. doi: 10.1152/ajpheart.00001.2014
Bisht, Kavita, Tampe, Jens, Shing, Cecilia, Bakrania, Bhavisha, Winearls, James, Fraser, John, Wagner, Karl-Heinz and Bulmer, Andrew C. (2014). Endogenous tetrapyrroles influence leukocyte responses to lipopolysaccharide in human blood: pre-clinical evidence demonstrating the anti-inflammatory potential of biliverdin. Journal of Clinical and Cellular Immunology, 5 (3), 1000218. doi: 10.4172/2155-9899.1000218
Boon, Ai-Ching, Hawkins, Clare L., Bisht, Kavita, Coombes, Jeff S., Bakrania, Bhavisha, Wagner, Karl-Heinz and Bulmer, Andrew C. (2012). Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free Radical Biology and Medicine, 52 (10), 2120-2127. doi: 10.1016/j.freeradbiomed.2012.03.002
Conference Papers
Spradley, Frank, Bakrania, Bhavisha, Eddy, Adrian, Granger, Joey and Rana, Sarosh (2023). Treatment with the flavonoid, luteolin, attenuates the development of placental ischemia-induced hypertension in pregnant rats. American Physiology Summit 2023, Long Beach, CA United States, 20–23 April 2023. Rockville, MD United States: American Physiological Society. doi: 10.1152/physiol.2023.38.s1.5733831
Bakrania, Bhavisha A., Palei, Ana, Shahul, Sajid, Hall, Michael and Granger, Joey P. (2022). Aspirin Treatment Improves Excess Activin A Associated Cardiac Dysfunction In Pregnancy. Experimental Biology Meeting EB 2022, Philadelphia, PA United States, 2-5 April 2022. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.2022.36.S1.R3288
Bakrania, Bhavisha A., Spradley, Frank T., Patel, Bijalben R., Travis, Adam B., Sandner, Peter and Granger, Joey P. (2019). Soluble Guanylate Cyclase Activators Increase cGMP Expression and Improve Vascular Function and Placental Ischemia-Induced Hypertension. Experimental Biology Meeting (EB), Orlando Fl, Apr 06-09, 2019. HOBOKEN: WILEY.
Bakrania, Bhavisha A., Spradley, Frank T., Travis, Adam B., Sandner, Peter and Granger, Joey P. (2018). Abstract 013: soluble guanylate cyclase activators improve vascular function and attenuate placental ischemia-induced hypertension. American Heart Association's Joint Hypertension 2018 Scientific Sessions, Unknown, Unknown. Philadelphia, PA USA: Lippincott Williams & Wilkins. doi: 10.1161/hyp.72.suppl_1.013
Bakrania, Bhavisha A., Spradley, Frank T., Travis, Adam B., Sandner, Peter and Granger, Joey P. (2018). Soluble Guanylate Cyclase Activators Improve Vascular Function and Attenuate Placental Ischemia-Induced Hypertension. American Heart Association's Joint Hypertension 2018 Scientific Sessions, Chicago, IL United States, 6-9 September 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1161/hyp.72.suppl_1.013
Paauw, Nina, Joles, Jaap, Spradley, Frank, Bakrania, Bhavisha, Franx, Arie, Verhaar, Marianne, Granger, Joey and Lely, Titia (2016). 79 Renal and cardiac disturbances 8 weeks after exposure to placental ischemia in rat dams. Congress of the International Society for the Study of Hypertension in Pregnancy, Sao Paolo, Brazil, 2016. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.preghy.2016.08.080
Bakrania, B., Du Toit, E., Headrick, J. and Bulmer, A. (2012). Endogenously elevated and exogenously administered bilirubin protects from myocardial ischaemia/reperfusion injury in the rat. Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Brisbane, QLD Australia, 16-19 August 2012. Chatswood, NSW Australia: Elsevier Australia. doi: 10.1016/j.hlc.2012.05.202
Data Collections
Morwood, Holly, Bakrania, Bhavisha A., Wright, Ian M. R., Eiby, Yvonne A. and Lingwood, Barbara E. (2022). Measuring blood volume in preterm piglets. The University of Queensland. (Dataset) doi: 10.48610/65b722d
Forbes, Elizabeth, Bakrania, Bhavisha, Steans, Sarah, Moritz, Karen, Lingwood, Barbara and Eiby, Yvonne (2022). Cardiac TRPM6 and 7 piglets. The University of Queensland. (Dataset) doi: 10.48610/0dac82b