Dr Malcolm Lim
NHMRC Research Officer
UQ Centre for Clinical Research
+61 7 334 66120
Researcher biography
Dr Malcolm Lim is a molecular biologist currently working in the field of breast cancer brain metastasis in Prof Sunil Lakhani's Lab at The University of Queensland Centre for Clinical Research.
His research interest is in understanding the mechanisms underlying development of brain metastases, identification of new therapeutic targets, and how to improve brain metastasis treatment using novel therapeutic approaches.
He graduated with a BSc (Hons) in biomedical science and gained his PhD in molecular biology from the University of Queensland. His doctoral studies were focused on human epidermal growth factor receptors (HER) and the therapeutic and diagnostic potential of HER2/HER3-targeting hyperbranched polymeric nanomedicine for delivery of chemo- and radiotherapy in breast cancer brain metastasis.
Prior to his academic career, he was a laboratory scientist in a diagnostic histopathology laboratory for 5 years (2010-2015).
Journal Articles
Lim, Malcolm, Fletcher, Nicholas, Reed, Amy Mccart, Flint, Melanie, Thurecht, Kristofer, Saunus, Jodi and Lakhani, Sunil R. (2022). Modeling brain metastasis by internal carotid artery injection of cancer cells. Journal of Visualized Experiments, 2022 (186) e64216. doi: 10.3791/64216
Saunus, Jodi M., De Luca, Xavier M., Northwood, Korinne, Raghavendra, Ashwini, Hasson, Alexander, McCart Reed, Amy E., Lim, Malcolm, Lal, Samir, Vargas, A. Cristina, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Kalaw, Emarene, Kalita-de Croft, Priyakshi, Gresshoff, Irma, Al-Ejeh, Fares, Gee, Julia M. W., Ormandy, Chris, Khanna, Kum Kum, Beesley, Jonathan, Chenevix-Trench, Georgia, Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Nicolau, Dan V., Simpson, Peter T. and Lakhani, Sunil R. (2022). Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. npj Breast Cancer, 8 (1) 57, 57. doi: 10.1038/s41523-022-00425-x
Lim, Malcolm, Nguyen, Tam H., Niland, Colleen, Reid, Lynne E., Jat, Parmjit S., Saunus, Jodi M. and Lakhani, Sunil R. (2022). Landscape of epidermal growth factor receptor heterodimers in brain metastases. Cancers, 14 (3), 533. doi: 10.3390/cancers14030533
Croft, Priyakshi Kalita-de, Chittoory, Haarika, Nguyen, Tam H., Saunus, Jodi M., Kim, Woo Gyeong, Reed, Amy E. McCart, Lim, Malcolm, De Luca, Xavier M., Ferguson, Kaltin, Niland, Colleen, Mazzieri, Roberta, Dolcetti, Riccardo, Simpson, Peter T. and Lakhani, Sunil R. (2021). Characterization of immune cell subsets of tumor infiltrating lymphocytes in brain metastases. Biology, 10 (5) 425, 425. doi: 10.3390/biology10050425
Kalaw, Emarene, Lim, Malcolm, Kutasovic, Jamie R., Sokolova, Anna, Taege, Lucinda, Johnstone, Kate, Bennett, James, Saunus, Jodi M., Niland, Colleen, Ferguson, Kaltin, Gresshoff, Irma, Bettington, Mark, Pathmanathan, Nirmala, Tse, Gary M., Papadimos, David, Pathmanathan, Rajadurai, Harris, Gavin, Yamaguchi, Rin, Tan, Puay Hoon, Fox, Stephen, O’Toole, Sandra A., Simpson, Peter T., Lakhani, Sunil R. and McCart Reed, Amy E. (2020). Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1. British Journal of Cancer, 123 (11), 1665-1672. doi: 10.1038/s41416-020-01065-3
Kalita-de Croft, Priyakshi, Lim, Malcolm, Chittoory, Haarika, de Luca, Xavier M., Kutasovic, Jamie R., Day, Bryan W., Al-Ejeh, Fares, Simpson, Peter T., McCart Reed, Amy E., Lakhani, Sunil R. and Saunus, Jodi M. (2020). Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases. Therapeutic Advances in Medical Oncology, 12, 175883592094625. doi: 10.1177/1758835920946259
Adwal, Alaknanda, Kalita-de Croft, Priyakshi, Shakya, Reshma, Lim, Malcolm, Kalaw, Emarene, Taege, Lucinda D., McCart Reed, Amy E., Lakhani, Sunil R., Callen, David F. and Saunus, Jodi M. (2020). Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer. Life Science Alliance, 3 (7) e201900562, e201900562. doi: 10.26508/lsa.201900562
Hernández-Pérez, S., Cabrera, E., Salido, E., Lim, M., Reid, L., Lakhani, S. R., Khanna, K. K., Saunus, J. M. and Freire, R. (2019). Correction: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer (Oncogene, (2017), 36, 33, (4802-4809), 10.1038/onc.2017.21). Oncogene, 38 (24), 4886-4886. doi: 10.1038/s41388-019-0753-2
Kalita-de Croft, Priyakshi, Straube, Jasmin, Lim, Malcolm, Al-Ejeh, Fares, Lakhani, Sunil R. and Saunus, Jodi M. (2019). Proteomic analysis of the breast cancer brain metastasis microenvironment. International Journal of Molecular Sciences, 20 (10) 2524, 2524. doi: 10.3390/ijms20102524
Lim, Malcolm, Puttick, Simon, Houston, Zachary H., Thurecht, Kristofer J., Kalita-de Croft, Priyakshi, Mahler, Stephen, Rose, Stephen E., Jeffree, Rosalind L., Mazzieri, Roberta, Dolcetti, Riccardo, Lakhani, Sunil R. and Saunus, Jodi M. (2019). Innovative therapeutic strategies for effective treatment of brain metastases. International Journal of Molecular Sciences, 20 (6) 1280. doi: 10.3390/ijms20061280
McCart Reed, Amy Ellen, Kalaw, Emarene, Nones, Katia, Bettington, Mark, Lim, Malcolm, Bennett, James, Johnstone, Kate, Kutasovic, Jamie Rose, Saunus, Jodi Marie, Kazakoff, Stephen, Xu, Qinying, Wood, Scott, Holmes, Oliver, Leonard, Conrad, Reid, Lynne Estelle, Black, Debra, Niland, Colleen, Ferguson, Kaltin, Gresshoff, Irma, Raghavendra, Ashwini, Harvey, Kate, Cooper, Caroline, Liu, Cheng, Kalinowski, Lauren, Reid, Andrew Scott, Davidson, Morgan, Pearson, John V, Pathmanathan, Nirmala, Tse, Gary ... Lakhani, Sunil R. (2019). Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications. Journal of Pathology, 247 (2), 214-227. doi: 10.1002/path.5184
How, Guo Yuan, Chang, Kenneth Tou En, Jacobsen, Anette Sundfor, Yap, Te-Lu, Ong, Caroline Choo Phaik, Low, Yee, Allen, John Carson, Kuick, Chik Hong, Lim, Malcolm Zhun Leong and Laksmi, Narasimhan Kannan (2018). Neuronal defects an etiological factor in congenital pelviureteric junction obstruction?. Journal of Pediatric Urology, 14 (1), 51.e1-51.e7. doi: 10.1016/j.jpurol.2017.07.014
Hernández-Pérez, S., Cabrera, E., Salido, E., Lim, M., Reid, L., Lakhani, S. R., Khanna, K. K., Saunus, J. M. and Freire, R. (2017). Erratum: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer (Oncogene (2017) 36 33 (4802-4809)). Oncogene, 36 (33), 4817-4817. doi: 10.1038/onc.2017.220
Hernandez-Perez, S., Cabrera, E., Salido, E., Lim, M., Reid, L., Lakhani, S. R., Khanna, K. K., Saunus, J. M. and Freire, R. (2017). DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer. Oncogene, 36 (33), 4802-4809. doi: 10.1038/onc.2017.21
Saunus, Jodi M., McCart Reed, Amy E., Lim, Zhun Leong and Lakhani, Sunil R. (2017). Breast cancer brain metastases: clonal evolution in clinical context. International Journal of Molecular Sciences, 18 (1) 152, 152. doi: 10.3390/ijms18010152
Yan, Benedict, Kuick, Chik Hong, Lim, Malcolm, Yong, Min Hwee, Lee, Chi Kuen, Low, Sharon Y.Y., Low, David C.Y., Lim, Diana, Soh, Shui Yen and Chang, Kenneth T.E. (2016). Characterization of anaplastic lymphoma kinase-positive medulloblastomas. Journal of Clinical Neuroscience, 23, 120-122. doi: 10.1016/j.jocn.2015.08.017
Yan, Benedict, Kuick, Chik Hong, Lim, Malcolm, Venkataraman, Kavita, Tennakoon, Chandana, Loh, Eva, Lian, Derrick, Leong, May Ying, Lakshmanan, Manikandan, Tergaonkar, Vinay, Sung, Wing-Kin, Soh, Shui Yen and Chang, Kenneth T.E. (2014). Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas. PLoS ONE, 9 (9) e106575, e106575. doi: 10.1371/journal.pone.0106575
Yan, Benedict, Lim, Malcolm, Zhou, Lihan, Kuick, Chik Hong, Leong, May Ying, Yong, Kol Jia, Aung, LeLe, Salto-Tellez, Manuel and Chang, Kenneth T. E. (2013). Identification of MET genomic amplification, protein expression and alternative splice isoforms in neuroblastomas. Journal of Clinical Pathology, 66 (11), 985-991. doi: 10.1136/jclinpath-2012-201375
Conference Papers
Saunus, J. M., Lim, M., Puttick, S., Croft, P. Kalita-de, Houston, Z. H., Jones, M. L., Latter, M. J., Campbell, L. C., Thomas, P., Jeffree, R. L., Rose, S. E., Mahler, S. M., Thurecht, K. J., Scott, A. M. and Lakhani, S. R. (2019). Innovation in diagnosis and treatment of brain metastases using multifunctional nanomedicines. San Antonio Breast Cancer Symposium, San Antonio, Texas, 4-8 December 2018. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS18-P1-19-02
Reed, A. E. McCart, Kalaw, E., Nones, K., Bettington, M., Lim, M., Bennett, J., Johnstone, K., Kutasovic, J. R., Kazakoff, S., Xu, Q. C., Saunus, J. M., Reid, L. E., Black, D., Niland, C., Ferguson, K., Gresshoff, I., Raghavendra, A., Liu, J. C., Kalinowski, L., Reid, A. S., Davidson, M., Pearson, J. V., Yamaguchi, R., Harris, G., Tse, G., Papadimos, D., Pathmanathan, R., Pathmanathan, N., Tan, P. H. ... Lakhani, S. R. (2019). Dissecting the heterogeneity of metaplastic breast cancer: a morphological, immunohistochemical and genomic analysis of a large cohort. San Antonio Breast Cancer Symposium, San Antonio, TX, United States, 4-8 December 2018. Philadelphia, PA, United States: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.SABCS18-P3-08-03
Saunus, J. M., Croft, P. K.-D., Lee, F. T., Al-Ejeh, F., Lim, M., Ensbey, K., Niland, C., Jeffree, R. L., Thomas, P., Day, B. W., Rose, S., Scott, A. M. and Lakhani, S. R. (2017). Investigating the HER2-3 dimer as a theranostic target in brain metastases. 16th Biennial Congress of the Metastasis Research Society, Chengdu, China, 16-20 September 2016. Dordrecht, Netherlands: Springer. doi: 10.1007/s10585-017-9843-0
Saunus, Jodi M., Kalita-de Croft, Priyakshi, Lee, F. T., Al-Ejeh, Fares, Lim, Malcolm, Ensbey, Kathleen, Niland, Colleen, Jeffree, Rosalind L., Thomas, Paul, Day, Bryan W., Rose, Stephen, Scott, Andrew M. and Lakhani, Sunil R. (2016). Investigating the Her2-3 dimer as a theranostic target in brain metastases. COSA's 43 and ANZBCTG's 38 Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care, Gold Coast, QLD Australia, 15-17 November 2016. Chichester, West Sussex United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ajco.12646
Thesis
Lim, Malcolm (2022). Development of theranostic nanomedicines for breast cancer brain metastases. PhD Thesis, Medicine Faculty, The University of Queensland. doi: 10.14264/1e7615d