Translational neuroscience of episodic memory function in aging and disease 

Presented by Dr Arnold Bakker

Overview

The medial temporal lobe and specifically the hippocampus is critically important for memory and memory impairment. Our studies have focused not only on the role of the hippocampus, but particularly the discreet role of the hippocampal subregions in our ability to recall facts and events. The memory task used in these studies was based on the proposed role of hippocampal subregions. 

This talk aims to discuss a series of studies using these methods showing alterations in hippocampal subregion specific functions in cognitively normal elderly compared to young adults, and an even greater change in patients with amnestic mild cognitive impairment compared to age-matched controls. These studies additionally showed increased hippocampal activation localized to the DG/CA3 subregion of the hippocampus in these patients compared to healthy control participants. This hippocampal over activation has been recognized as a characteristic feature of the MCI phase of Alzheimer’s disease and a target for the development of new therapeutic interventions.

About Dr Arnold Bakker

Dr Arnold Bakker

Dr Arnold Bakker is an Assistant Professor of Psychiatry and Behavioral Sciences 
in the Division of Psychiatric Neuroimaging at the Johns Hopkins University School of Medicine. 

About CCR Seminars

The UQ Centre of Clinical Research Seminars (CCR) are held fortnightly on Wednesdays from 12pm - 1pm (except during school holidays) in the CCR Auditorium, Herston. The series features topics in the following fields of research, presented by invited international, interstate and local researchers.