Overview: Morpho-kinetic features of early cleavage-stage embryos are known to be important predictors of embryo quality and IVF treatment outcome. A prominent feature of good-quality embryos is the ability to produce equal-sized daughter-cells with each division, termed symmetrical division.  Conversely, asymmetrical divisions leading to variable blastomere sizes is a red flag for poor developmental potential. Notably, very little is known about the origins of division asymmetry in embryos. Using high-resolution 4D live imaging to track chromosomes during the first cleavage division in mouse embryos, we uncovered a circuitous nuclear centring process that risks embryonic divisions becoming asymmetric in early mouse embryos.

About UQCCR Seminar Series

UQCCR Seminar Series

The UQ Centre of Clinical Research (UQCCR) Seminars are held fortnightly on Wednesdays from 12 pm - 1 pm (except during school holidays) currently on Zoom. The series features topics in multiple research fields, presented by invited international, interstate and local researchers.



Zoom https://uqz.zoom.us/j/87198801358
Zoom https://uqz.zoom.us/j/87198801358