The main focus of Dr Greer’s lab is diseases affecting the nervous system, particularly those in which the immune system plays (or may play) a role. The major diseases that the lab focuses on are multiple sclerosis (MS) and schizophrenia. 

A major aim of the research is to determine what role antibodies directed against different parts of the brain play in each of these diseases. 


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  • In vitro culture of human and animal cells and testing in immunological assays, including proliferation, cytokine secretion, cell activation, flow cytometry, ELISA, ELISPOT
  • Experimental autoimmune encephalomyelitis; in vivo assessment of specific immunomodulatory agents
  • Histological analysis of brain tissues, including immunohistochemistry, confocal microscopy.
  • Proteomic approaches to study brain proteins, including affinity and size-exclusion chromatography, 1D & 2D gels, Western blotting, protein purification
  • Molecular Biological approaches including HLA typing, RT-PCR, RNase protection assays, DNA sequencing