Associate Professor Lata Vadlamudi
Theme Leader for Brain, Neurology and Mental Health
Principal Research Fellow
UQ Centre for Clinical Research
Researcher biography
Associate Professor Lata Vadlamudi is a Senior Staff Specialist in Neurology at the Royal Brisbane and Women's Hospital; Epileptologist within the Comprehensive Epilepsy Program; Metro North Clinician Research Fellow; and Neurosciences Theme Leader at the University of Queensland Centre for Clinical Research. She is a Group Leader at UQCCR and her research group is entitled Epilepsy Research- Precision-based management. Webpage- https://clinical-research.centre.uq.edu.au/vadlamudi-group
She obtained her medical degree from the University of QLD and completed physician training in the field of Neurology. Further specialized training in epilepsy was undertaken in Melbourne, Sydney and the Mayo Clinic, USA. PhD was obtained from the University of Melbourne, which was entitled "The Genetics of Epilepsy: The Testimony of Twins".
Clinical interests include integrating genomics into clinical care and management of women with epilepsy, in particular during pregnancy. Current research projects include developing patient-specific organoid models to personalise epilepsy care and a current MRFF-funded stem cell therapies PERSIST mission; RNA therapeutics; genomic and epigenomic studies in epilepsy, with a particular interest in twin studies.
Awards have included Metro North Clinician Research Fellowship; Highly Commended Clinical Research Award by Metro North Hospital and Health Service, Epilepsy Queensland Health Award for contributions to the medical care of people with epilepsy; and Leonard Cox Award from the Australian and New Zealand Association of Neurologists for outstanding contribution to research in the field of Neurology
Journal Articles
Perucca, Piero, Bourikas, Dimitrios, Voinescu, P. Emanuela, Vadlamudi, Lata, Chellun, Daya, Kumke, Thomas, Werhahn, Konrad J. and Schmitz, Bettina (2024). Lacosamide and pregnancy: Data from spontaneous and solicited reports. Epilepsia. doi: 10.1111/epi.17924
Green, Timothy E., Bennett, Mark F., Immisch, Ilka, Freeman, Jeremy L., Klein, Karl Martin, Kerrigan, John F., Vadlamudi, Lata, Heinzen, Erin L., Scheffer, Ingrid E., Harvey, A. Simon, Rosenow, Felix, Hildebrand, Michael S. and Berkovic, Samuel F. (2023). Mosaic variants detectable in blood extend the clinico-genetic spectrum of GLI3-related Hypothalamic Hamartoma. Genetics in Medicine Open, 1 (1) 100810, 100810. doi: 10.1016/j.gimo.2023.100810
Gordon, Louisa G., Elliott, Thomas M., Bennett, Carmen, Hollway, Georgina, Waddell, Nicola and Vadlamudi, Lata (2022). Early cost‐utility analysis of genetically‐guided therapy for patients with drug‐resistant epilepsy. Epilepsia, 63 (12), 3111-3121. doi: 10.1111/epi.17408
Vadlamudi, Lata, Bennett, Carmen Maree, Tom, Melanie, Abdulsarool, Ghusoon, Brion, Kristian, Lundie, Ben, Aung, Hnin, Lau, Chiyan, Rodgers, Jonathan, Riney, Kate and Gordon, Louisa (2022). A multi-disciplinary team approach to genomic testing for drug-resistant epilepsy patients. Journal of Clinical Medicine, 11 (14) 4238, 1-16. doi: 10.3390/jcm11144238
Hunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J. and Vadlamudi, Lata (2022). Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening. Stem Cell Research, 60 102673, 102673. doi: 10.1016/j.scr.2022.102673
Hunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J. and Vadlamudi, Lata (2021). Generation of induced pluripotent stem cell lines from peripheral blood mononuclear cells of three drug resistant and three drug responsive epilepsy patients. Stem Cell Research, 56 102564, 102564. doi: 10.1016/j.scr.2021.102564
Rodriguez-Acevedo, Astrid J., Gordon, Louisa G., Waddell, Nicola, Hollway, Georgina and Vadlamudi, Lata (2021). Developing a gene panel for pharmacoresistant epilepsy: a review of epilepsy pharmacogenetics. Pharmacogenomics, 22 (4) pgs-2020-0145, 225-234. doi: 10.2217/pgs-2020-0145
Mohandas, Namitha, Loke, Yuk Jing, Mackenzie, Lisa, Bennett, Carmen, Berkovic, Samuel F., Craig, Jeffrey M. and Vadlamudi, Lata (2019). Deciphering the role of epigenetics in self-limited epilepsy with centrotemporal spikes. Epilepsy Research, 156 106163, 106163. doi: 10.1016/j.eplepsyres.2019.106163
Mohandas, Namitha, Loke, Yuk Jing, Hopkins, Stephanie, Mackenzie, Lisa, Bennett, Carmen, Berkovic, Samuel F., Vadlamudi, Lata and Craig, Jeffrey M. (2019). Evidence for type-specific DNA methylation patterns in epilepsy: a discordant monozygotic twin approach. Epigenomics, 11 (8) epi-2018-0136, 951-968. doi: 10.2217/epi-2018-0136
Zhang, Yue-Hua, Burgess, Rosemary, Malone, Jodie P., Glubb, Georgie C., Helbig, Katherine L., Vadlamudi, Lata, Kivity, Sara, Afawi, Zaid, Bleasel, Andrew, Grattan-Smith, Padraic, Grinton, Bronwyn E., Bellows, Susannah T., Vears, Danya F., Damiano, John A., Goldberg-Stern, Hadassa, Korczyn, Amos D., Dibbens, Leanne M., Ruzzo, Elizabeth K., Hildebrand, Michael S., Berkovic, Samuel F. and Scheffer, Ingrid E. (2017). Genetic epilepsy with febrile seizures plus: refining the spectrum. Neurology, 89 (12), 1210-1219. doi: 10.1212/WNL.0000000000004384
Vadlamudi, Lata, Milne, Roger L., Lawrence, Kate, Heron, Sarah E., Eckhaus, Jazmin, Keay, Deborah, Connellan, Mary, Torn-Broers, Yvonne, Howell, R. Anne, Mulley, John C., Scheffer, Ingrid E., Dibbens, Leanne M., Hopper, John L. and Berkovic, Samuel F. (2014). Genetics of epilepsy: The testimony of twins in the molecular era. Neurology, 83 (12), 1042-1048. doi: 10.1212/WNL.0000000000000790
Scheffer, Ingrid E., Heron, Sarah E., Regan, Brigid M., Mandelstam, Simone, Crompton, Douglas E., Hodgson, Bree L., Licchetta, Laura, Provini, Federica, Bisulli, Francesca, Vadlamudi, Lata, Gecz, Jozef, Connelly, Alan, Tinuper, Paolo, Ricos, Michael G., Berkovic, Samuel F. and Dibbens, Leanne M. (2014). Mutations in mammalian target of rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations. Annals of Neurology, 75 (5), 782-787. doi: 10.1002/ana.24126
Eckhaus, Jazmin, Lawrence, Kate M., Helbig, Ingo, Bui, Minh, Vadlamudi, Lata, Hopper, John L., Scheffer, Ingrid E. and Berkovic, Samuel F. (2013). Genetics of febrile seizure subtypes and syndromes: a twin study. Epilepsy Research, 105 (1-2), 103-109. doi: 10.1016/j.eplepsyres.2013.02.011
Vadlamudi, Lata, Dibbens, Leanne M., Lawrence, Kate M., Iona, Xenia, McMahon, Jacinta M., Murrell, Wayne, Mackay-Sim, Alan, Scheffer, Ingrid E. and Berkovic, Samuel F. (2010). Timing of de novo mutagenesis - A twin study of sodium-channel mutations. New England Journal of Medicine, 363 (14), 1335-1340. doi: 10.1056/NEJMoa0910752
Helbig, Ingo, Lawrence, Kate, Connellan, Mary, Torn-Broers, Yvonne, Vadlamudi, Lata, Eckhaus, Jazmin, Milne, Roger, Hopper, John and Berkovic, Samuel (2008). Obstetric events as a risk factor for febrile seizures: A community-based twin study. Twin Research and Human Genetics, 11 (6), 634-640. doi: 10.1375/twin.11.6.634
Helbig, Ingo, Matigian, Nicholas A., Vadlamudi, Lata, Lawrence, Kate M., Bayly, Marta A., Bain, Sharon M., Diyagama, Dileepa, Scheffer, Ingrid E., Mulley, John C., Holloway, Andrew J., Dibbens, Leanne M., Berkovic, Samuel F. and Hayward, Nicholas K. (2008). Gene expression analysis in absence epilepsy using a monozygotic twin design. Epilepsia, 49 (9), 1546-1554. doi: 10.1111/j.1528-1167.2008.01630.x
Berkovic, Samuel F., Dibbens, Leanne M., Oshlack, Alicia, Silver, Jeremy D., Katerelos, Marina, Vears, Danya F., Lüllmann-Rauch, Renate, Blanz, Judith, Zhang, Ke Wei, Stankovich, Jim, Kalnins, Renate M., Dowling, John P., Andermann, Eva, Andermann, Frederick, Faldini, Enrico, D'Hooge, Rudi, Vadlamudi, Lata, Macdonell, Richard A., Hodgson, Bree L., Bayly, Marta A., Savige, Judy, Mulley, John C., Smyth, Gordon K., Power, David A., Saftig, Paul and Bahlo, Melanie (2008). Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis. The American Journal of Human Genetics, 82 (3), 673-684. doi: 10.1016/j.ajhg.2007.12.019
McRae, A. F., Matigian, N. A., Vadlamudi, L., Mulley, J. C., Mowry, B., Martin, N. G., Berkovic, S. F., Hayward, N. K. and Visscher, P. M. (2007). Replicated effects of sex and genotype on gene expression in human lymphoblastoid cell lines. Human Molecular Genetics, 16 (4), 364-373. doi: 10.1093/hmg/ddl456
Jansen, F. E., Sadleir, L. G., Harkin, L. A., Vadlamudi, L., McMahon, J. M., Mulley, J. C., Scheffer, I. E. and Berkovic, S. F. (2006). Severe myoclonic epilepsy of infancy (Dravet syndrome): Recognition and diagnosis in adults. Neurology, 67 (12), 2224-2226. doi: 10.1212/01.wnl.0000249312.73155.7d
Vadlamudi, L., Vears, D. F., Hughes, A., Pedagogos, E. and Berkovic, S. F. (2006). Action myoclonus–renal failure syndrome: A cause for worsening tremor in young adults. Neurology, 67 (7), 1310-1311. doi: 10.1212/01.wnl.0000238424.23177.5e
Vadlamudi, Lata, Kjeldsen, Marianne J., Corey, Linda A., Solaas, Marit H., Friis, Mogen L., Pellock, John M., Nakken, Karl O., Milne, Roger L., Sceffer, Ingrid E., Harvey, A. Simon, Hopper, John L. and Berkovic, Samuel F. (2006). Analyzing the etiology of benign rolandic epilepsy: A multicenter twin collaboration. Epilepsia, 47 (3), 550-555. doi: 10.1111/j.1528-1167.2006.00466.x
Vadlamudi, L., Hatton, R., Byth, K., Harasty, J., Vogrin, S., Cook, M. J. and Bleasel, A. F. (2006). Volumetric analysis of a specific language region – the planum temporale. Journal of Clinical Neuroscience, 13 (2), 206-213. doi: 10.1016/j.jocn.2005.03.026
Vadlamudi, Lata, Harvey, A. Simon, Hopper, John L., Scheffer, Ingrid E. and Berkovic, Samuel F. (2005). Reply: Genetic influence on rolandic epilepsy. Annals of Neurology, 57 (3), 465-465. doi: 10.1002/ana.20398
Vadlamudi, Lata, So, Elson L., Worrell, Gregory A., Mosewich, Russell K., Cascino, Gregory D., Meyer, Fredic B. and Lesnick, Timothy G. (2004). Factors underlying scalp‐EEG interictal epileptiform discharges in intractable frontal lobe epilepsy. Epileptic Disorders, 6 (2), 89-95.
Vadlamudi, L., Andermann, E., Lombroso, C. T. and et al. (2004). Epilepsy in twins: Insights from unique historical data of William Lennox. Neurology, 62 (7), 1127-1133. doi: 10.1212/01.WNL.0000118201.89498.48
Vadlamudi, Lata, Harvey, Simon A., Connellan, Mary M., Milne, Roger L., Hopper, J. L., Scheffer, I. E. and Berkovic, S. F. (2004). Is benign Rolandic epilepsy genetically determined?. Annals of Neurology, 56 (1), 129-132. doi: 10.1002/ana.20153
Vadlamudi, L., Westmoreland, B. F., Klass, D. W. and Parisi, J. E. (2003). Electroencephalographic findings in Kufs disease. Clinical Neurophysiology, 114 (9), 1738-1743. doi: 10.1016/S1388-2457(03)00111-1
Vadlamudi, L., Scheffer, I. E. and Berkovic, S. F. (2003). Genetics of temporal lobe epilepsy. Journal of Neurology, Neurosurgery and Psychiatry, 74 (10), 1359-1361. doi: 10.1136/jnnp.74.10.1359
Vadlamudi, Lata and Wijdicks, Eelco F.M. (2002). Multifocal myoclonus due to verapamil overdose. Neurology, 58 (6), 984-985. doi: 10.1212/WNL.58.6.984
Mitchell, S. J., Benson, M., Vadlamudi, L. and Miller, P. (2000). Cerebral arterial gas embolism by helium: An unusual case successfully treated with hyperbaric oxygen and lidocaine. Annals of Emergency Medicine, 35 (3), 300-303. doi: 10.1016/S0196-0644(00)70086-2
Vadlamudi, L., Galton, C. J., Jeavons, S. J., Tannenberg, A. E. G. and Boyle, R. S. (2000). Rasmussen's syndrome in a 54 year old female: more support for an adult variant. Journal of Clinical Neuroscience, 7 (2), 154-156. doi: 10.1054/jocn.1999.0173
Conference Papers
Dibbens, L. M., Scheffer, I. E., Regan, B. M., Mandelstam, S., Crompton, D. E., Hodgson, B. L., Licchetta, L., Provini, F., Bisulli, F., Vadlamudi, L., Gecz, J., Connelly, A., Tinuper, P., Ricos, M. G., Berkovic, S. F. and Heron, S. E. (2014). Mutations in Depdc5 Are a Major Cause of Lesional and Non-Lesional Focal Epilepsy. 11th European Congress on Epileptology, Stockholm, Sweden, Jun 29-Jul 03, 2014. Hoboken, NJ, United States : Wiley-Blackwell Publishing. doi: 10.1111/epi.12675
Vadlamudi, L., Kjeldsen, N. J., Corey, L. A., Solaas, A. H., Friis, M. L., Pellock, J. M., Nakken, K. O., Milne, R. L., Scheffer, N. E., Harvey, S. A. and Berkovic, S. F. (2004). Is benign rolandic epilepsy genetically determined?. Annual Meeting of the American Epilepsy Society, New Orleans, LA, United States, 3-7 December 2004. Hoboken, NJ, United States: Wiley-Blackwell Publishing.
Vadlamudi, Lata , Somerville, Ernst , Neocleous, V., Mulley, John , Bertrand, D. and Berkovic, Samuel (2003). Do parasomnias and nocturnal frontal lobe epilepsy share the same molecular mechanisms? . Annual Meeting of the American Epilepsy Society, Boston, MA, United States, 5-10 December 2003.
Vadlamudi, Lata , Andermann, Eva , Lombroso, C. T. , Schachter, S. C., Roger Milne, John Hopper, Fred Andermann and Samuel Berkovic (2003). William Lennox’s twin studies compared with recent data: Lessons in classification and genetics. Annual Meeting of the American Epilepsy Society, Boston, MA, United States, 5-10 December 2003.
Vadlamudi, Lata , Andermann, Eva , Lombroso, C. T., Schachter, S. C., Andermann, Fred and Berkovic, Samuel (2003). Epilepsy in Twins: Insights from unique historical data of William Lennox. Annual Meeting of the American Academy of Neurology, Honolulu, HI, United States, 29 March-5 April 2003.
Vadlamudi, Lata , Parisi, John and Westmoreland, Barbara (2002). The EEG findings in Kufs disease. Annual Meeting of the Canadian Congress of Neurological Sciences, Vancouver, BC, Canada, 18-22 June 2002.
Vadlamudi, Lata , So, Elson , Worrell, Greg , Cascino, Greg and Lesnick, Tom (2001). Factors underlying scalp-EEG interictal epileptiform discharges in intractable frontal lobe epilepsy.. American Epilepsy Society, Philadelphia, PA, United Sates, 30 November-5 December 2001.
Vadlamudi, Lata , Galton, Clare , Jeavons, Susan , Tannenberg, Anthony and Boyle, Richard (1999). Rasmussens's Syndrome in a fifty-four year old female- More support for an adult variant. Meeting of the 23rd International Epilepsy Congress, Prague, Czech Republic, 12-17 September 1999.