Dr Emma Sweeney
Senior Research Fellow
UQ Centre for Clinical Research
Keywords: Mycoplasma, Ureaplasma, Neisseria, antimicrobial resistance, molecular biology
Type of research: Pre-clinical research, translational research
| Featured projects | Duration |
|---|---|
|
Cytomegalovirus in Children receiving Haematopoietic Stem Cell Transplantation Children’s Hospital Foundation |
2020–2024 |
Book Chapter
Dando, Samantha J. , Sweeney, Emma L. and Knox, Christine L. (2019). Ureaplasma. Bergey's manual of systematics of archaea and bacteria. (pp. 1-28) edited by William B. Whitman. London, United Kingdom: Wiley. doi: 10.1002/9781118960608.gbm01264.pub3
Journal Articles
Bryan, Emily R., McRae, Julia, Kumar, Vishnu, Trim, Logan K, Maidment, Toby I, Tickner, Jacob A D, Sweeney, Emma L, William, Elizabeth D, Whiley, David M and Beagley, Kenneth W (2024). A novel murine model mimicking male genital Neisseria species infection using Neisseria musculi. Biology of Reproduction, 111 (3), 613-624. doi: 10.1093/biolre/ioae100
Bell, Sara F. E., Sweeney, Emma L., Kong, Fabian Y. S., Whiley, David M., Bradshaw, Catriona S. and Tickner, Jacob A. (2024). Response to the ASHM 2023 statement on the use of doxy-PEP in Australia: considerations and recommendations. Medical Journal of Australia, 220 (7), 356-360. doi: 10.5694/mja2.52255
Ertl, Nicole G., Anderson, Taylah K., Pardo, Carolyn J., Maidment, Toby I., Murray, Gerald L., Bradshaw, Catriona S., Whiley, David M. and Sweeney, Emma L. (2024). Concurrent parC and gyrA fluoroquinolone resistance mutations and associated strains in Mycoplasma genitalium in Queensland, Australia. Journal of Antimicrobial Chemotherapy, 79 (2), 467-469. doi: 10.1093/jac/dkad373
Hume, Jocelyn, Lowry, Kym, Whiley, David M., Irwin, Adam D., Bletchly, Cheryl and Sweeney, Emma L. (2023). Application of the ViroKey® SQ FLEX assay for detection of cytomegalovirus antiviral resistance. Journal of Clinical Virology, 167 105556, 1-8. doi: 10.1016/j.jcv.2023.105556
Murray, Gerald L, Plummer, Erica L, Bodiyabadu, Kaveesha, Vodstrcil, Lenka A, Huaman, Jose L, Danielewski, Jennifer A, Chua, Teck Phui, Machalek, Dorothy A, Garland, Suzanne, Doyle, Michelle, Sweeney, Emma L, Whiley, David M and Bradshaw, Catriona S (2023). gyrA mutations in Mycoplasma genitalium and their contribution to moxifloxacin failure: time for the next generation of resistance-guided therapy. Clinical Infectious Diseases, 76 (12), 2187-2195. doi: 10.1093/cid/ciad057
Hume, Jocelyn, Sweeney, Emma L., Lowry, Kym, Fraser, Chris, Clark, Julia E., Whiley, David M. and Irwin, Adam D. (2023). Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance. Frontiers in Pediatrics, 11 1180392, 1180392. doi: 10.3389/fped.2023.1180392
Divithotewala, Chandima, Sweeney, Emma L., Burke, Andrew, Graves, Bianca, Stewart, Adam, Whiley, David, Heney, Claire, Hopkins, Peter M. and Chambers, Daniel C. (2023). Mycoplasma hominis and Ureaplasma urealyticum infections in the immediate post-lung transplant period: A case series and literature review. Transplant Infectious Disease, 25 (3) e14058, 1-7. doi: 10.1111/tid.14058
Alharbi, Bushra, Jennison, Amy V., Hicks, Vicki, Whiley, David M, Sweeney, Emma and Trembizki, Ella (2023). Decreased Neisseria gonorrhoeae genotypic diversity following COVID-19 restrictions in Queensland, Australia 2020. Epidemiology and Infection, 151 e67, 1-8. doi: 10.1017/S0950268823000523
Mulvey, Peter B. M., Trim, Logan K., Aaskov, John G., Bryan, Emily R., Sweeney, Emma L., Kollipara, Avinash, Plenderleith, Mark B., Aldwell, Frank E. and Beagley, Kenneth W. (2022). Primary oral vaccination followed by a vaginal pull protects mice against genital HSV‐2 infection. American Journal of Reproductive Immunology, 89 (3) e13668, 1-11. doi: 10.1111/aji.13668
Vodstrcil, Lenka A., Plummer, Erica L., Doyle, Michelle, Murray, Gerald L., Bodiyabadu, Kaveesha, Jensen, Jorgen S., Whiley, David, Sweeney, Emma, Williamson, Deborah A., Chow, Eric P. F., Fairley, Christopher K. and Bradshaw, Catriona S. (2022). Combination Therapy for Mycoplasma genitalium, and New Insights Into the Utility of parC Mutant Detection to Improve Cure. Clinical Infectious Diseases, 75 (5), 813-823. doi: 10.1093/cid/ciab1058
Sweeney, Emma L, Bradshaw, Catriona S, Murray, Gerald L and Whiley, David M (2022). Can ParC Ser83Ile status predict fluoroquinolone efficacy in Mycoplasma genitalium infection? – Authors’ reply. The Lancet Infectious Diseases, 22 (9), 1274-1275. doi: 10.1016/S1473-3099(22)00446-7
Jonduo, Marinjho Emely, Vallely, Lisa Michelle, Wand, Handan, Sweeney, Emma Louise, Egli-Gany, Dianne, Kaldor, John, Vallely, Andrew John and Low, Nicola (2022). Adverse pregnancy and birth outcomes associated with Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum: a systematic review and meta-analysis. BMJ Open, 12 (8) e062990, 1-12. doi: 10.1136/bmjopen-2022-062990
Jonduo, Marinjho E., Vallely, Andrew J., Whiley, David M., Riddell, Michaela A., Pomat, William, Low, Nicola and Sweeney, Emma L. (2022). Mycoplasma genitalium macrolide and fluoroquinolone resistance in pregnant women in Papua New Guinea. Sexually Transmitted Infections, 99 (1) 055552, 71-72. doi: 10.1136/sextrans-2022-055552
Sweeney, Emma L., Whiley, David M., Murray, Gerald L. and Bradshaw, Catriona S. (2022). Mycoplasma genitalium: enhanced management using expanded resistance-guided treatment strategies. Sexual Health, 19 (4), 248-254. doi: 10.1071/sh22012
Sweeney, Emma L., Lowry, Kym, Seel, Mandy, Rahimi, Frashta, Langton-Lockton, Julian, Bletchly, Cheryl, Nimmo, Graeme R. and Whiley, David M. (2022). Two Treponema pallidum strains account for the majority of syphilis infections, including among females, in Queensland, Australia. Communicable Diseases Intelligence, 46. doi: 10.33321/cdi.2022.46.26
Murray, Gerald L., Bodiyabadu, Kaveesha, Vodstrcil, Lenka A., Machalek, Dorothy A., Danielewski, Jennifer, Plummer, Erica L., Garland, Suzanne M., Whiley, David M., Sweeney, Emma L. and Bradshaw, Catriona S. (2022). parC Variants in Mycoplasma genitalium: trends over time and association with moxifloxacin failure. Antimicrobial Agents and Chemotherapy, 66 (5) e0027822, e0027822. doi: 10.1128/aac.00278-22
Tickner, Jacob A., Bradshaw, Catriona S., Murray, Gerald L., Whiley, David M. and Sweeney, Emma L. (2022). Novel probe-based melting curve assays for the characterization of fluoroquinolone resistance in Mycoplasma genitalium. Journal of Antimicrobial Chemotherapy, 77 (6), 1592-1599. doi: 10.1093/jac/dkac097
Sweeney, Emma L., Bradshaw, Catriona S., Murray, Gerald L. and Whiley, David M. (2022). Individualised treatment of Mycoplasma genitalium infection—incorporation of fluoroquinolone resistance testing into clinical care. The Lancet Infectious Diseases, 22 (9), e267-e270. doi: 10.1016/s1473-3099(21)00629-0
Willie, Barne, Sweeney, Emma L., Badman, Steven G., Chatfield, Mark, Vallely, Andrew J., Kelly-Hanku, Angela and Whiley, David M. (2022). The prevalence of antimicrobial resistant Neisseria gonorrhoeae in Papua New Guinea: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 19 (3) 1520, 1520. doi: 10.3390/ijerph19031520
Beale, Mathew A., Marks, Michael, Cole, Michelle J., Lee, Min-Kuang, Pitt, Rachel, Ruis, Christopher, Balla, Eszter, Crucitti, Tania, Ewens, Michael, Fernández-Naval, Candela, Grankvist, Anna, Guiver, Malcolm, Kenyon, Chris R., Khairullin, Rafil, Kularatne, Ranmini, Arando, Maider, Molini, Barbara J., Obukhov, Andrey, Page, Emma E., Petrovay, Fruzsina, Rietmeijer, Cornelis, Rowley, Dominic, Shokoples, Sandy, Smit, Erasmus, Sweeney, Emma L., Taiaroa, George, Vera, Jaime H., Wennerås, Christine, Whiley, David M. ... Thomson, Nicholas R. (2021). Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis. Nature Microbiology, 6 (12), 1549-1560. doi: 10.1038/s41564-021-01000-z
Mhango, Lebogang P., Trembizki, Ella, Thng, Caroline, Whiley, David M. and Sweeney, Emma L. (2021). Exploring the implications for coincidental treatment of Mycoplasma genitalium infection in Neisseria
gonorrhoeae-positive patients. JAC - Antimicrobial Resistance, 3 (1) dlab033, dlab033. doi: 10.1093/jacamr/dlab033
Sweeney, Emma L., Lowry, Kym, Bletchly, Cheryl, Nimmo, Graeme R. and Whiley, David M. (2021). Mycoplasma genitalium infections can comprise a mixture of both fluoroquinolone-susceptible and fluoroquinolone-resistant strains. Journal of Antimicrobial Chemotherapy, 76 (4), 887-892. doi: 10.1093/jac/dkaa542
Kenyon, Johanna J., Arbatsky, Nikolay P., Sweeney, Emma L., Zhang, Yang, Senchenkova, Sofya N., Popova, Anastasiya V., Shneider, Mikhail M., Shashkov, Alexander S., Liu, Bin, Hall, Ruth M. and Knirel, Yuriy A. (2021). Involvement of a multifunctional rhamnosyltransferase in the synthesis of three related Acinetobacter baumannii capsular polysaccharides, K55, K74 and K85. International Journal of Biological Macromolecules, 166, 1230-1237. doi: 10.1016/j.ijbiomac.2020.11.005
Sweeney, Emma L., Lowry, Kym, Ebeyan, Samantha, Lundgren, Marie and Whiley, David M. (2020). Evaluation of the SpeeDx MG parC (beta) PCR assay for the rapid detection of Mycoplasma genitalium quinolone resistance-associated mutations. Journal of Clinical Microbiology, 58 (10) e0143220, 1-2. doi: 10.1128/jcm.01432-20
Sweeney, Emma L., Tickner, Jacob, Bletchly, Cheryl, Nimmo, Graeme R. and Whiley, David M. (2020). Genotyping of Mycoplasma genitalium suggests de novo acquisition of antimicrobial resistance, Queensland, Australia. Journal of Clinical Microbiology, 58 (9) e00641-20. doi: 10.1128/jcm.00641-20
Sweeney, E. L., Mhango, L. P., Ebeyan, S., Tan, L. Y., Bletchly, C., Nimmo, G. R. and Whiley, D. M. (2020). Evaluation of the ResistancePlus® MG FleXible cartridge for near point-of-care testing of Mycoplasma genitalium and associated macrolide resistance mutations. Journal of Clinical Microbiology, 58 (3) e01897-19. doi: 10.1128/jcm.01897-19
Sweeney, Emma L., Gardiner, Stephanie, Tickner, Jacob, Trim, Logan, Beagley, Kenneth W. and Carey, Alison J. (2020). Group B Streptococcus serotypes Ia and V induce differential vaginal immune responses that may contribute to long term colonization of the female reproductive tract. American Journal of Reproductive Immunology, 83 (1) e13199, e13199. doi: 10.1111/aji.13199
Sweeney, Emma L., Bletchly, Cheryl, Gupta, Rita and Whiley, David M. (2019). False-negative Chlamydia polymerase chain reaction result caused by a cryptic plasmid-deficient Chlamydia trachomatis strain in Australia. Sexual Health, 16 (4), 394-396. doi: 10.1071/sh18205
Kenyon, Johanna J., Arbatsky, Nikolay P., Sweeney, Emma L., Shashkov, Alexander S., Shneider, Mikhail M., Popova, Anastasia V., Hall, Ruth M. and Knirel, Yuriy A. (2019). Production of the K16 capsular polysaccharide by Acinetobacter baumannii ST25 isolate D4 involves a novel glycosyltransferase encoded in the KL16 gene cluster. International Journal of Biological Macromolecules, 128, 101-106. doi: 10.1016/j.ijbiomac.2019.01.080
Sweeney, E. L., Trembizki, E., Bletchly, C., Bradshaw, C. S., Menon, A., Francis, F., Langton-Lockton, J., Nimmo, G. R. and Whiley, D. M. (2019). Levels of Mycoplasma genitalium antimicrobial resistance differ by both region and gender in the state of Queensland, Australia: implications for treatment guidelines. Journal of Clinical Microbiology, 57 (3) e01555-18. doi: 10.1128/jcm.01555-18
Sweeney, E. L., Al-Shehri, S. S., Cowley, D. M., Liley, H. G., Bansal, N., Charles, B. G., Shaw, P. N., Duley, J. A. and Knox, C. L. (2018). The effect of breastmilk and saliva combinations on the in vitro growth of oral pathogenic and commensal microorganisms. Scientific Reports, 8 (1) 15112, 15112. doi: 10.1038/s41598-018-33519-3
Wee, Bryan A., Thomas, Mark, Sweeney, Emma Louise, Frentiu, Francesca D., Samios, Melanie, Ravel, Jacques, Gajer, Pawel, Myers, Garry, Timms, Peter, Allan, John A. and Huston, Wilhelmina M. (2018). A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women. Australian & New Zealand Journal of Obstetrics & Gynaecology, 58 (3), 341-348. doi: 10.1111/ajo.12754
Sweeney, Emma L., Kallapur, Suhas G., Meawad, Simone, Gisslen, Tate, Stephenson, Sally-Anne, Jobe, Alan H. and Knox, Christine L. (2017). Ureaplasma Species Multiple Banded Antigen (MBA) Variation Is Associated with the Severity of Inflammation In vivo and In vitro in Human Placenta. Frontiers in Cellular and Infection Microbiology, 7 (APR) 123. doi: 10.3389/fcimb.2017.00123
Sweeney, Emma L., Dando, Samantha J., Kallapur, Suhas G. and Knox, Christine L. (2017). The Human Ureaplasma Species as Causative Agents of Chorioamnionitis. Clinical Microbiology Reviews, 30 (1), 349-379. doi: 10.1128/CMR.00091-16
Al-Shehri, S. S., Sweeney, E. L., Cowley, D. M., Liley, H. G., Ranasinghe, P. D., B. G. Charles,, Shaw, P. N., Vagenas, D., Duley, J. A. and Knox, C. L. (2016). Deep sequencing of the 16S ribosomal RNA of the neonatal oral microbiome: a comparison of breast-fed and formula-fed infants. Scientific Reports, 6 (1) 38309, 38309. doi: 10.1038/srep38309
Prince, Amanda L., Ma, Jun, Kannan, Paranthaman S., Alvarez, Manuel, Gisslen, Tate, Harris, Alan, Sweeney, Emma L., Knox, Christine L., Lambers, Donna S., Jobe, Alan H., Chougnet, Claire A., Kallapur, Suhas G. and Aagaard, Kjersti M. (2016). The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis. American Journal of Obstetrics and Gynecology, 214 (5), 627.e1-627.e16. doi: 10.1016/j.ajog.2016.01.193
Sweeney, Emma L., Kallapur, Suhas G., Gisslen, Tate, Lambers, Donna S., Chougnet, Claire A., Stephenson, Sally-Anne, Jobe, Alan H. and Knox, Christine L. (2016). Placental Infection With Ureaplasma species Is Associated With Histologic Chorioamnionitis and Adverse Outcomes in Moderately Preterm and Late-Preterm Infants. Journal of Infectious Diseases, 213 (8), 1340-1347. doi: 10.1093/infdis/jiv587
Salomon, Carlos, Scholz-Romero, Katherin, Sarker, Suchismita, Sweeney, Emma, Kobayashi, Miharu, Correa, Paula, Longo, Sherri, Duncombe, Gregory, Mitchell, Murray D., Rice, Gregory E. and Illanes, Sebastian E. (2016). Gestational diabetes mellitus is associated with changes in the concentration and bioactivity of placenta-derived exosomes in maternal circulation across gestation. Diabetes, 65 (3), 598-609. doi: 10.2337/db15-0966
Rice, Gregory E., Scholz-Romero, Katherin, Sweeney, Emma, Peiris, Hassendrini, Kobayashi, Miharu, Duncombe, Gregory, Mitchell, Murray D. and Salomon, Carlos (2015). The Effect of Glucose on the Release and Bioactivity of Exosome from First Trimester Totrophoblast Cells. Journal of Clinical Endocrinology and Metabolism, 100 (10), E1280-E1288. doi: 10.1210/jc.2015-2270
Al-Shehri, Saad S., Knox, Christine L., Liley, Helen G., Cowley, David M., Wright, John R., Henman, Michael G., Hewavitharana, Amitha K., Charles, Bruce G., Shaw, Paul N., Sweeney, Emma L. and Duley, John A. (2015). Breastmilk-saliva interactions boost innate immunity by regulating the oral microbiome in early infancy. PLoS One, 10 (9) e0135047, e0135047.1-e0135047.19. doi: 10.1371/journal.pone.0135047
Conference Papers
Murray, Gerald, Plummer, Erica L., Bodihabadu, Kaveesha, Torres, Jose, Chua, Teck-Phui, Machalek, Dorothy, Garland, Suzanne M., Doyle, Michelle, Sweeney, Emma L., Whiley, David and Bradshaw, Catriona (2024). gyrA Mutations in Mycoplasma Genitalium Contribute to Moxifloxacin Failure - A New Target For Resistance-guided Therapy. Annual Meeting of the Infectious-Diseases-Society-for-Obstetrics-and-Gynecology (IDSOG), Boston, MA, United States, 4-6 August 2022. Philadelphia, PA, United States: Lippincott Williams & Wilkins.
Sweeney, Emma L., Bradshaw, Catriona, Murray, Gerald, Tickner, Jacob A. and Whiley, David (2024). Simplifying approaches to detect Mycoplasma genitalium parC resistance mutations, to facilitate individualised fluoroquinolone treatment. Annual Meeting of the Infectious-Diseases-Society-for-Obstetrics-and-Gynecology (IDSOG), Boston, MA, United States, 4-6 August 2022. Philadelphia, PA, United States: Lippincott Williams & Wilkins.
Scholz-Romero, Katherin, Sweeney, Emma, Truong, Grace, Kobayashi, Miharu, Peiris, Hassendrini, Duncombe, Gregory, Mitchell, Murray, Rice, Gregory and Salomon, Carlos (2015). Hypoxia and high glucose modulate the bioactivity of placental exosomes on endothelial cells. International Federation of Placenta Associations Meeting, Brisbane, QLD Australia, 2015. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2015.07.196