Dr Kirat Chand

Postdoctoral Research Fellow

UQ Centre for Clinical Research

+61 7 334 66016

k.chand@uq.edu.au

Featured projects	Duration
Stem cell treatment for neonatal hypoxic ischemic encephalopathy National Health and Medical Research Council	2018–2020
Improving brain outcomes in the growth restricted newborn using placental stem cell treatment	2018–2020
Contribution of systemic inflammatory response to brain injury in growth restricted newborns National Health and Medical Research Council	2018–2019
Improving brain oxygen levels in babies using stem cell treatment Children’s Hospital Foundation	2017–2019

Publications

Journal Articles (11)

Conference Papers (7)

Thesis (1)

Journal Articles

Wixey, Julie A., Sukumar, Kishen R., Pretorius, Rinaldi, Lee, Kah Meng, Colditz, Paul B., Bjorkman, S. Tracey and Chand, Kirat K. (2019) Ibuprofen treatment reduces the neuroinflammatory response and associated neuronal and white matter impairment in the growth restricted newborn. Frontiers in Physiology, 10 541. doi:10.3389/fphys.2019.00541

Wixey, Julie A., Lee, Kah Meng, Miller, Stephanie M., Goasdoue, Kate, Colditz, Paul B., Bjorkman, S.T. and Chand, Kirat K. (2019). Neuropathology in intrauterine growth restricted newborn piglets is associated with glial activation and proinflammatory status in the brain. Journal of Neuroinflammation, 16 (1) 5, doi:10.1186/s12974-018-1392-1

Wixey, Julie A., Chand, Kirat K., Pham, Lily, Colditz, Paul B. and Bjorkman, S. Tracey (2018). Therapeutic potential to reduce brain injury in growth restricted newborns. Journal of Physiology, 596 (23) 5675-5686. doi:10.1113/JP275428

Wixey, Julie A, Reinebrant, Hanna E, Chand, Kirat K and Buller, Kathryn M (2018). Disruption to the 5-HT7 Receptor Following Hypoxia-Ischemia in the Immature Rodent Brain. Neurochemical research, 43 (3) 711-720. doi:10.1007/s11064-018-2473-3

Chand, Kirat K., Lee, Kah Meng, Lee, John D., Qiu, Hao, Willis, Emily F., Lavidis, Nickolas A., Hilliard, Massimo A. and Noakes, Peter G. (2018) Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 32 5: fj201700835R-2689. doi:10.1096/fj.201700835R

Wixey, Julie A., Chand, Kirat K., Colditz, Paul B. and Bjorkman, S. Tracey (2017) Neuroinflammation in intrauterine growth restriction. Placenta, 54 117-124. doi:10.1016/j.placenta.2016.11.012

Lee, Kah Meng, Chand, Kirat K., Hammond, Luke A., Lavidis, Nickolas A. and Noakes , Peter G. (2017) Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression. Aging, 9 3: 880-899. doi:10.18632/aging.101198

Kirat Chand, Kah Lee, Lavidis, Nickolas A. and Noakes, Peter G. (2016) Loss of laminin-alpha4 results in pre- and postsynaptic modifications at the neuromuscular junction. FASEB Journal, 31 4: 1323-1336.doi:10.1096/fj.201600899R

Miller, Stephanie, M., Sullivan, Susan (Williams), Zoe Ireland, Kirat Chand, Colditz, Paul B. and Bjorkman, Stella Tracey (2016) Neonatal seizures are associated with redistribution and loss of GABAA α-subunits in the hypoxic-ischaemic pig. Journal of Neurochemistry, 139 3: 471-484.doi:10.1111/jnc.13746

Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala and Noakes, Peter G. (2016) Tick holocyclotoxins trigger host paralysis by presynaptic inhibition. Scientific Reports, 6 29446. doi:10.1038/srep29446

Kirat Chand, Kah Lee, Mitja Schenning, Lavidis, Nickolas A. and Noakes, Peter G. (2015) Loss of β2-laminin alters calcium sensitivity and voltage gated calcium channel maturation of neurotransmission at the neuromuscular junction. Journal of Physiology, 593 1: 245-265.doi:10.1113/jphysiol.2014.284133

Conference Papers

Goasdoue, Kate, Chand, Kirat Kishore, Miller, Stephanie Melita, Lee, Kah Meng, Colditz, Paul Bernard, Wixey, Julie Anne and Bjorkman, Stella Tracey (2019).Seizures are associated with blood-brain barrier disruption in a piglet model of neonatal hypoxic-ischaemic encephalopathy. 11th Hershey Conference on Developmental Brain Injury, Asilomar, CA, United States, 5-8 June 2018. Basel, Switzerland :S. Karger AG. doi: 10.1159/000499365

Wixey, Julie, Sukumar, Kishen, Miller, Stephanie, Goasdoue, Kate, Colditz, Paul, Bjorkman, Stella Tracey and Chand, Kirat (2017).Anti-inflammatory treatment to reduce brain injury in the growth restricted neonate. 31st Annual Fetal and Neonatal Workshop of Australia and New Zealand, Canberra, ACT, Australia, 30-31 March 2017.

Sukumar, K., Chand, K., Miller, S., Goasdoue, K., Colditz, P., Bjorkman, S. T. and Wixey, J. (2017).Neuroinflammation in the IUGR piglet model. Queensland Perinatal Consortium, Translational Research Institute, Brisbane, 20 July 2017.

Goasdoue, K., Miller, S., Chand, K., Wixey, J., Colditz, P. and Bjorkman, S. T. (2017).Inflammation and blood-brain barrier disruption occurs rapidly following neonatal hypoxic-ischaemic encephalopathy. Queensland Perinatal Consortium, Brisbane, Australia, 20 July 2017.

Goasdoue, Kate, Miller, Stephanie, Chand, Kirat, Wixey, Julie, Colditz, Paul and Bjorkman, Tracey (2016).Investigation of the impact of seizures on disruption to the blood-brain barrier following neonatal hypoxia-ischaemia. Queensland Perinatal Consortium, Brisbane, Queensland, Australia: University of Queensland, 15 July, 2016.

Eiby, Yvonne, Bjorkman, Tracey, Wixey, Julie, Chand, Kirat, Colditz, Paul and Lingwood, Barbara (2016).Pilot trial of early blood transfusions for supporting cardiovascular function and cerebral oxygen delivery in preterm piglets. 30th Annual meeting Fetal and Neonatal Workshop of Australia and New Zealand, Magnetic Island, QLD, Australia, 19-21 May 2016.

Wixey, Julie, Muller, Camille, Chand, Kirat, Sullivan, Susan, Colditz, Paul and Bjorkman, Stella Tracey (2016).Neuroinflammatory response in the growth restricted neonate. Australasian Neuroscience Society Annual Scientific Meeting, Hobart, TAS, Australia, 4-7 December 2016.

Thesis

Chand, Kirat Kishore (2015). The functional role of laminins-α4 and -β2 in development of the neuromuscular junction. PhD Thesis, School of Biomedical Sciences, The University of Queensland. doi:10.14264/uql.2015.339