As a neonatal physiologist, I have dedicated my research career to improving cardiovascular support for clinical management of preterm infants for optimal health outcomes. Over the past 11 years, I have established a tertiary level neonatal intensive care unit for very preterm piglets to understand the unique cardiovascular system of preterm neonates. Using this pre-clinical model, we now have insight into unique aspects of preterm cardiovascular physiology. With our clinical collaborators, we are at the forefront of novel therapy development to provide effective cardiovascular support for preterm infants.
| Featured projects | Duration |
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Loss of blood volume at the capillary level contributes to poor outcomes for preterm infants National Health and Medical Research Council |
2020–2023 |
Journal Articles
Eiby, Yvonne A., Lingwood, Barbara E. and Wright, Ian M. R. (2021). Plasma leak from the circulation contributes to poor outcomes for preterm infants: a working hypothesis. Frontiers in Neurology, 12 636740, 1-9. doi: 10.3389/fneur.2021.636740
Lingwood, Barbara E., Al-Theyab, Nada, Eiby, Yvonne A., Colditz, Paul B. and Donovan, Tim J. (2020). Body composition in very preterm infants before discharge is associated with macronutrient intake. British Journal of Nutrition, 123 (7), 1-19. doi: 10.1017/S000711451900343X
Lingwood, Barbara E., Eiby, Yvonne A., Bjorkman, S. Tracey, Miller, Stephanie M. and Wright, Ian M. R. (2019). Supporting preterm cardiovascular function. Clinical and Experimental Pharmacology and Physiology, 46 (3), 274-279. doi: 10.1111/1440-1681.13044
Al-Theyab, N. A., Donovan, T. J., Eiby, Y. A., Colditz, P. B. and Lingwood, B. E. (2019). Fat trajectory after birth in very preterm infants mimics healthy term infants. Pediatric Obesity, 14 (3) e12472, e12472. doi: 10.1111/ijpo.12472
Eiby, Yvonne A., Shrimpton, Nicole Y., Wright, Ian M. R., Lumbers, Eugenie R., Colditz, Paul B., Duncombe, Greg J. and Lingwood, Barbara E. (2018). Reduced blood volume decreases cerebral blood flow in preterm piglets. The Journal of Physiology, 596 (23), 6033-6041. doi: 10.1113/JP275583
Barnes, Samuel K., Eiby, Yvonne A., Lee, Soohyun, Lingwood, Barbara E. and Dawson, Paul A (2017). Structure, organization and tissue expression of the pig SLC13A1 and SLC13A4 sulfate transporter genes. Biochemistry and Biophysics Reports, 10, 215-223. doi: 10.1016/j.bbrep.2017.04.005
Ratnasingham, Abirami, Eiby, Yvonne A., Dekker Nitert, Marloes, Donovan, Timothy and Lingwood, Barbara E. (2017). Review: Is rapid fat accumulation in early life associated with adverse later health outcomes?. Placenta, 54, 125-130. doi: 10.1016/j.placenta.2017.01.101
Eiby, Yvonne A., Shrimpton, Nicole Y. , Wright, Ian M. R. , Lumbers, Eugenie R., Colditz, Paul B. , Duncombe, Greg J. and Lingwood, Barbara E. (2016). Inotropes do not increase cardiac output or cerebral blood flow in preterm piglets. Pediatric Research, 80 (6), 870-879. doi: 10.1038/pr.2016.156
Kim, Eleanor, Eiby, Yvonne, Lumbers, Eugenie, Boyce, Amanda, Gibson, Karen and Lingwood, Barbara (2015). Expression of genes of the cardiac and renal renin-angiotensin systems in preterm piglets: is this system a suitable target for therapeutic intervention?. Therapeutic Advances in Cardiovascular Disease, 9 (5), 285-296. doi: 10.1177/1753944715578615
Eiby, Yvonne A., Lumbers, Eugenie R., Staunton, Michael P., Wright, Layne L., Colditz, Paul B., Wright, Ian M. R. and Lingwood, Barbara E. (2014). Endogenous angiotensins and catecholamines do not reduce skin blood flow or prevent hypotension in preterm piglets. Physiological Reports, 2 (12) e12245, 1-13. doi: 10.14814/phy2.12245
Kim, Min Young, Eiby, Yvonne A., Lumbers, Eugenie R., Wright, Layne L., Gibson, Karen J., Barnett, Amanda C. and Lingwood, Barbara E. (2014). Effects of glucocorticoid exposure on growth and structural maturation of the heart of the preterm piglet. PLoS One, 9 (3) e93407, e93407.1-e93407.9. doi: 10.1371/journal.pone.0093407
Kim, Min Young, Finch, Angela M., Lumbers, Eugenie R., Boyce, Amanda C., Gibson, Karen J., Eiby, Yvonne A. and Lingwood, Barbara E. (2014). Expression of adrenoceptor subtypes in preterm piglet heart is different to term heart. PLoS One, 9 (3) e92167, e92167.1-e92167.7. doi: 10.1371/journal.pone.0092167
Eiby, Yvonne A., Wright, Layne L., Kalanjati, Viskasari P., Miller, Stephanie M., Bjorkman, Stella T., Keates, Helen L., Lumbers, Eugenie R., Colditz, Paul B. and Lingwood, Barbara E. (2013). A Pig Model of the Preterm Neonate: Anthropometric and Physiological Characteristics. PLoS ONE, 8 (7) e68763, e68763. doi: 10.1371/journal.pone.0068763
Eiby, Yvonne A., Lumbers, Eugenie R., Headrick, John P. and Lingwood, Barbara E. (2012). Left ventricular output and aortic blood flow in response to changes in preload and afterload in the preterm piglet heart. American Journal of Physiology, 303 (7), R769-R777. doi: 10.1152/ajpregu.00010.2012
Eiby, Yvonne A. and Booth, David T. (2011). Determining optimal incubation temperature for a head-start program: The effect of incubation temperature on hatchling Burnett River snapping turtles (Elseya albagula). Australian Journal of Zoology, 59 (1), 18-25. doi: 10.1071/ZO10080
Eiby, Y.A and Booth, D.T. (2009). The effects of incubation temperature on the morphology and composition of Australian Brush-turkey (Alectura lathami) chicks. Journal of Comparative Physiology B, 179 (7), 875-882. doi: 10.1007/s00360-009-0370-4
Eiby, Yvonne A., Worthington Wilmer, Jessica and Booth, David T. (2008). Temperature-dependent sex-biased embryo mortality in a bird. Proceedings of the Royal Society of London - B - Biological Sciences, 275 (1652), 2703-2706. doi: 10.1098/rspb.2008.0954
Eiby, Yvonne and Booth, David (2008). Embryonic thermal tolerance and temperature variation in mounds of the Australian Brush-turkey (Alectura lathami). The Auk, 125 (3), 594-599. doi: 10.1525/auk.2008.07083
Conference Papers
Dawson, P. A., Eiby, Y. A., Barnes, S. K., Boyd, R. N., Badawi, N., Koorts, P. J., Kumar, S., Flenady, V. J., Hurrion, E. M, Colditz, P. B. and Lingwood, B. E. (2018). Preterm Piglets Are a Model of Human Preterm Infant Sulphate Deficiency. 22nd Annual Congress of the Perinatal Society of Australia and New Zealand (PSANZ), Auckland, New Zealand, 25–28 March 2018. Chichester, West Sussex United Kingdom: Wiley. doi: 10.1111/jpc.13882_186
Dawson, Paul, Lingwood, Barbara, Eiby, Yvonne, Barnes, Samuel, Colditz, Paul, Boyd, Roslyn, Badawi, Nadia, Koorts, Pieter, Kumar, Sailesh, Flenady, Vicki and Hurrion, Elizabeth (2017). Plasma sulphate levels decline in the neonatal preterm piglet. 21st Annual Congress of the Perinatal Society of Australia and New Zealand (PSANZ), Canberra, Australia, 2–5 April, 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jpc.13494_68
Eiby, Yvonne, Bjorkman, Tracey, Wixey, Julie, Chand, Kirat, Colditz, Paul and Lingwood, Barbara (2016). Pilot trial of early blood transfusions for supporting cardiovascular function and cerebral oxygen delivery in preterm piglets. 30th Annual meeting Fetal and Neonatal Workshop of Australia and New Zealand, Magnetic Island, QLD, Australia, 19-21 May 2016.
Kim, M. Y., Eiby, Y. A., Lumbers, E. R., Boyce, A. C., Gibson, K. J. and Lingwood, B. E. (2011). Expression of Adrenoceptor Subtypes in the Preterm Pig Heart. Unknown, Unknown, Unknown. New York, NY, United States: Nature Publishing Group. doi: 10.1038/pr.2011.482
Data Collection
Forbes, Elizabeth, Bakrania, Bhavisha, Steans, Sarah, Moritz, Karen , Lingwood, Barbara and Eiby, Yvonne (2022). Cardiac TRPM6 and 7 piglets. The University of Queensland. (Dataset) doi: 10.48610/0dac82b
Thesis
Yvonne Eiby (2009). Incubation biology of the Australian Brush-turkey (Alectura lathami). PhD Thesis, School of Biological Sciences, The University of Queensland.