Peter holds a Science Honours degree and a PhD in Molecular Biology from the University of Liverpool in the UK. He moved to Australia in 2004 and helped Professor Lakhani establish the MBP group. He is a past NBCF Early Career Fellow, a Fellow of the Royal College of Pathologists of Australasia, and currently holds a joint teaching and research position at UQ (UQ Medicine and UQCCR).
Breast cancer is a very heterogeneous disease, making morphological classification and management of patients a significant challenge. For example, it remains difficult to predict which patients are at risk of their disease returning (recurrence), spreading (metastasis) or which patients will respond to a specific treatment. There has therefore been a concerted effort to supplement the morphological classification of breast disease with molecular parameters that can provide a clearer appreciation for this complexity and better predict tumour behaviour. This ideology has driven significant advancements in the field of molecular pathology research.
Invasive Lobular Carcinoma (ILC) are a common special subtype of breast cancer comprising up to 15% of all cases. They exhibit a very characteristic set of clinical, pathological and biological properties, including a progressive decline in survival, an infiltrative pattern of growth and down regulation of cell adhesion molecule, E-cadherin. Morphological variants exist that are associated with a worse outcome compared to the classic type. A large component of Peter's research focuses on aspects of this specific disease subtype, including understanding molecular determinants that predict tumour behaviour, and mechanisms of invasion and metastasis.