Jane is also Co-chair for the International Collaborative Network for N-of-1 Trials and Single-Case Designs.
Researcher biography
I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.
I played a key role in setting up and sustaining UQ's N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.
I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.
Publications
Book Chapters
Nikles, J., Hams, A., Sterling, M. and Evans, K. (2023). N-of-1 research designs. Grieve's modern musculoskeletal physiotherapy. (pp. 1-20) London, United Kingdom: Elsevier.
Nikles, Jane (2015). Where Are N-of-1 Trials Headed?. The essential guide to N-of-1 trials in health. (pp. 233-241) edited by Jane Nikles and Geoffrey Mitchell. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_17
Nikles, Jane and Mitchell, Geoffrey (2015). Introduction. The essential guide to N-of-1 trials in health. (pp. 1-8) edited by Jane Nikles and Geoffrey Mitchell. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_1
Nikles, Jane (2015). What are N-of-1 Trials?. The essential guide to N-of-1 trials in health. (pp. 9-17) edited by Jane Nikles and Geoffrey Mitchell. Dordecht, Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_2
Nikles, C. J., Mitchell, G. K., Del Mar, C. B. and Clavarino, A. (2005). Individualised medication effectiveness tests as a means of targeting stimulants to responders in attention deficit hyperactivity disorder. Attention Deficit Hyperactivity Disorder Research Developments. (pp. 169-187) edited by M. P. Larimer. New York, U.S.A.: Nova Science.
Journal Articles
Dexter, Ben, Smith, Annika, King, Rachel, Downs, Nathan J., Nikles, Catherine Jane, Parisi, Alfio V., Ho, Yik‐Hong and Harrison, Simone Lee (2023). Serial cross‐sectional observations of sun‐protective behaviors at an annual outdoor motorsport event in Tropical Queensland, Australia. Photochemistry and Photobiology, 99 (5), 1352-1356. doi: 10.1111/php.13773
Nikles, J., Evans, K., Hams, A. and Sterling, M. (2022). A systematic review of N-of-1 trials and single case experimental designs in physiotherapy for musculoskeletal conditions. Musculoskeletal Science and Practice, 62 102639, 102639. doi: 10.1016/j.msksp.2022.102639
de Zoete, Rutger M. J., Nikles, Jane, Coombes, Jeff S., Onghena, Patrick and Sterling, Michele (2022). The effectiveness of aerobic versus strengthening exercise therapy in individuals with chronic whiplash-associated disorder: a randomised single case experimental design study. Disability and Rehabilitation, 45 (21), 1-10. doi: 10.1080/09638288.2022.2127937
Nikles, Jane, Keijzers, Gerben, Mitchell, Geoffrey, Farrell, Scott F., Perez, Siegfried, Schug, Stephan, Ware, Robert S., McLean, Samuel A., Connelly, Luke B. and Sterling, Michele (2022). Pregabalin vs placebo to prevent chronic pain after whiplash injury in at-risk individuals: Results of a feasibility study for a large randomised controlled trial. Pain, 163 (2), E274-E284. doi: 10.1097/j.pain.0000000000002362
Bashford, Guy, Tan, Samuel X., McGree, James, Murdoch, Veronica and Nikles, Jane (2021). Comparing pregabalin and gabapentin for persistent neuropathic pain: a protocol for a pilot N-of-1 trial series. Contemporary Clinical Trials Communications, 24 100852, 100852. doi: 10.1016/j.conctc.2021.100852
Stunnenberg, Bas C, Berends, Joost, Griggs, Robert C, Statland, Jeffrey, Drost, Gea, Nikles, Jane, Groenewoud, Hans, van Engelen, Baziel G.M., Jan van der Wilt, Gert and Raaphorst, Joost (2021). N-of-1 trials in neurology: a systematic review. Neurology, 98 (2), e174-e185. doi: 10.1212/wnl.0000000000012998
Ritchie, Carrie, Clanchy, Kelly, Sterling, Michele, Tate, Robyn, Smits, Esther J., Day, Melissa, Nikles, Jane, Liimatainen, Jenna and Tweedy, Sean M. (2021). Evaluation of a physical activity promotion intervention for adults with whiplash associated disorders: a single-case experimental design study. Disability and Rehabilitation, 44 (23), 1-14. doi: 10.1080/09638288.2021.1989062
McDonald, Suzanne, Tan, Samuel X., Banu, Shamima, van Driel, Mieke, McGree, James M., Mitchell, Geoffrey and Nikles, Jane (2021). Correction to: Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: A protocol for a feasibility and acceptability study. The Patient - Patient-Centered Outcomes Research, 15 (2), 267-267. doi: 10.1007/s40271-021-00549-5
Nikles, Jane, Onghena, Patrick, Vlaeyen, Johan W.S., Wicksell, Rikard K., Simons, Laura E., McGree, James M. and McDonald, Suzanne (2021). Establishment of an international collaborative network for N-of-1 trials and single-case designs. Contemporary Clinical Trials Communications, 23 100826, 1-8. doi: 10.1016/j.conctc.2021.100826
McDonald, Suzanne, Tan, Samuel X., Banu, Shamima, van Driel, Mieke, McGree, James M., Mitchell, Geoffrey and Nikles, Jane (2021). Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: a protocol for a feasibility and acceptability study. The Patient - Patient-Centered Outcomes Research, 15 (2), 197-206. doi: 10.1007/s40271-021-00540-0
McDonald, Suzanne and Nikles, Jane (2021). N-of-1 trials in healthcare. Healthcare, 9 (3) 330, 330. doi: 10.3390/healthcare9030330
Nikles, Jane, Daza, Eric J., McDonald, Suzanne, Hekler, Eric and Schork, Nicholas J. (2021). Editorial: creating evidence from real world patient digital data. Frontiers in Computer Science, 2 636996. doi: 10.3389/fcomp.2020.636996
Neville, Christine C., Nikles, Catherine J., Neville, Emily K., Zamora, Angelique and Banu, Shamima (2020). Exercise improves the health and well‐being of people with dementia. Australasian Journal on Ageing, 39 (3), 311-312. doi: 10.1111/ajag.12837
Nikles, Jane, Mitchell, Geoffrey Keith, de Miranda Araújo, Rossiniê, Harris, Thomas, Heussler, Helen S., Punja, Salima, Vohra, Sunita and Senior, Hugh Edgar John (2020). A systematic review of the effectiveness of sleep hygiene in children with ADHD. Psychology, Health and Medicine, 25 (4), 497-518. doi: 10.1080/13548506.2020.1732431
Edelson, Jaclyn, Byrnes, Josh, Mitchell, Geoffrey, Heussler, Helen, Melaku, Megdelawit and Nikles, Jane (2020). Protocol for a longitudinal study of melatonin therapy and cost effectiveness analysis in stimulant-treated children with ADHD and insomnia: an N-of-1 trial. Contemporary Clinical Trials Communications, 17 100530, 100530. doi: 10.1016/j.conctc.2020.100530
Nikles, J., Tate, R. L., Mitchell, G., Perdices, M., McGree, J. M., Freeman, C., Jacob, S., Taing, M. W. and Sterling, M. (2019). Personalised treatments for acute whiplash injuries: A pilot study of nested N-of-1 trials in a multiple baseline single-case experimental design. Contemporary Clinical Trials Communications, 16 100480, 100480. doi: 10.1016/j.conctc.2019.100480
Clanchy, Kelly M., Tweedy, Sean M., Tate, Robyn L., Sterling, Michele, Day, Melissa A., Nikles, Jane and Ritchie, Carrie (2019). Evaluation of a novel intervention to improve physical activity for adults with whiplash associated disorders: Protocol for a multiple-baseline, single case experimental study. Contemporary Clinical Trials Communications, 16 100455, 100455. doi: 10.1016/j.conctc.2019.100455
Blackston, J. Walker, Chapple, Andrew G., McGree, James M., McDonald, Suzanne and Nikles, Jane (2019). Comparison of aggregated N-of-1 trials with parallel and crossover randomized controlled trials using simulation studies. Healthcare, 7 (4), 137-13. doi: 10.3390/healthcare7040137
Alemayehu, Chalachew, Mitchell, Geoff, Nikles, Jane, Aseffa, Abraham and Clavarino, Alexandra (2019). Acceptability and barriers to implementation of N-of-1 tests in Ethiopia-a qualitative study. BMC Medical Research Methodology, 19 (1) 192, 192. doi: 10.1186/s12874-019-0832-7
Nikles, J., O'Sullivan, J. D., Mitchell, G. K., Smith, S. S., McGree, J. M., Senior, H., Dissanyaka, N. and Ritchie, A. (2019). Protocol: using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson's disease. Contemporary Clinical Trials Communications, 15 100397, 100397. doi: 10.1016/j.conctc.2019.100397
Tate, R. L., Perdices, M., Rosenkoetter, U., Shadish, W., Vohra, S., Barlow, D. H., Horner, R., Kazdin, A., Kratochwill, T., McDonald, S., Sampson, M., Shamseer, L., Togher, L., Albin, R., Backman, C., Douglas, J., Evans, J. J., Gast, D., Manolov, R., Mitchell, G., Nickels, L., Nikles, J., Ownsworth, T., Rose, M., Schmid, C. H. and Wilson, B. (2019). Normes de présentation de recherche utilisant les protocoles à cas unique en interventions comportementales (SCRIBE-2016). Pratiques Psychologiques, 25 (2), 103-117. doi: 10.1016/j.prps.2018.11.001
Nikles, Jane, Khan, Subaat, Leou, John, Keijzers, Gerben, Ng, Joanna, Bond, Catherine, Nakamura, Gota, Le, Rhonda and Sterling, Michele (2019). A retrospective descriptive observational study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury. Emergency Medicine Australiasia, 31 (5) 1742-6723.13253, 805-812. doi: 10.1111/1742-6723.13253
Nikles, Jane, Keijzers, Gerben, De Silva, Muthuwahandi Ishan Diluka, Khan, Subaat and Sterling, Michele (2018). Use of and attitudes to the role of medication for acute whiplash injury: a preliminary survey of emergency department doctors: emergency department Whiplash Medication Survey. Emergency Medicine Australasia, 31 (3), 471-474. doi: 10.1111/1742-6723.13190
Alemayehu, Chalachew, Mitchell, Geoff, Nikles, Jane, Aseffa, Abraham and Clavarino, Alexandra (2018). Views and perceptions about locally manufactured medicines in Ethiopia: a qualitative study of physicians, patients and regulatory authorities. BMC Health Services Research, 18 (1) 624, 624. doi: 10.1186/s12913-018-3410-5
Alemayehu, Chalachew, Nikles, Jane and Mitchell, Geoffrey (2018). N-of-1 trials in the clinical care of patients in developing countries: a systematic review. Trials, 19 (1) 246, 246. doi: 10.1186/s13063-018-2596-5
Harris, Thomas and Nikles, Jane (2018). Herbal medicines used in the treatment of chronic insomnia and how they influence sleep patterns: a review. Journal of Complementary Medicine and Alternative Healthcare, 6 (1). doi: 10.19080/JCMAH.2018.06.555680
Alemayehu, Chalachew, Mitchell, Geoffrey and Nikles, Jane (2018). Barriers for conducting clinical trials in developing countries- A systematic review. International Journal for Equity in Health, 17 (1) 37, 37. doi: 10.1186/s12939-018-0748-6
Nikles, J., Keijzers, G., Mitchell, G., Schug, S., Ware, R., McLean, S. A., Connelly, L., Gibson, S., Farrell, S. F. and Sterling, M. (2018). Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial. Trials, 19 (1) 44, 1-11. doi: 10.1186/s13063-018-2450-9
Nikles, Jane, Yelland, Michael, Bayram, Clare, Miller, Graeme and Sterling, Michele (2017). Management of whiplash associated disorders in Australian general practice. BMC Musculoskeletal Disorders, 18 (1) 551, 551. doi: 10.1186/s12891-017-1899-0
Barrett, Fiona, Usher, Kim, Woods, Cindy, Harrison, Simone L, Nikles, Jane and Conway, Jane (2017). Sun protective behaviors at an outdoor entertainment event in Australia. Nursing and Health Sciences, 20 (1), 132-138. doi: 10.1111/nhs.12396
Alemayu, Chalachew, Mitchell, Geoffrey, Aseffa, Abraham, Clavarino, Alexandra, McGree, James and Nikles, Jane (2017). A series of N-of-1 trials to assess therapeutic interchangeability of two Enalapril formulations in the treatment of hypertension, Addis Ababa, Ethiopia. Trials, 18 (1) 470, 470. doi: 10.1186/s13063-017-2212-0
Nikles, Jane, Mitchell, Geoffrey, McKinlay, Lynne, Waugh, Mary-Clare, Epps, Adrienne, Carmont, Sue-Ann, Schluter, Philip J., Lloyd, Owen and Senior, Hugh (2017). A series of n-of-1 trials of stimulants in brain injured children. NeuroRehabilitation, 40 (1), 11-21. doi: 10.3233/NRE-161386
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2017). The single-case reporting guideline in behavioural interventions (SCRIBE) 2016 statement. Neuropsychological Rehabilitation, 27 (1), 1-15. doi: 10.1080/09602011.2016.1190533
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The single-case reporting guideline in BEhavioural Interventions (SCRIBE) 2016 statement. Remedial and Special Education, 37 (6), 370-380. doi: 10.1177/0741932516652893
Punja, Salima, Nikles, Catherine J., Senior, Hugh, Mitchell, Geoffrey, Schmid, Christopher H., Heussler, Helen, Witmans, Manisha and Vohra, Sunita (2016). Melatonin in youth: N-of-1 trials in a stimulant-treated ADHD Population (MYNAP): study protocol for a randomized controlled trial. Trials, 17 (1) 375, 375. doi: 10.1186/s13063-016-1499-6
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement. Aphasiology, 30 (7), 862-876. doi: 10.1080/02687038.2016.1178022
Cen, Ruiqi, Hussain, Azad, Pak, Kirk J., Mitchell, Geoffrey, Nikles, Jane, Gaudreau, Stephanie, Bazzano, Lydia A. and Breault, Joseph L. (2016). Do N-of-1 trials need IRB review?. Journal of Empirical Research on Human Research Ethics, 11 (3), 250-255. doi: 10.1177/1556264616662560
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The single-case reporting guideline in BEhavioural interventions (SCRIBE) 2016 Statement. Physical Therapy, 96 (7), e1-e10. doi: 10.2522/ptj.2016.96.7.e1
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement. Evidence-Based Communication Assessment and Intervention, 10 (1), 44-58. doi: 10.1080/17489539.2016.1190525
Harrison, S. L., Garzon-Chavez, D. R. and Nikles, C. J. (2016). Sun protection policies of Australian primary schools in a region of high sun exposure. Health Education Research, 31 (3), 416-428. doi: 10.1093/her/cyw020
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting Guideline in BEhavioural Interventions (SCRIBE) 2016 statement. Canadian Journal of Occupational Therapy, 83 (3), 184-195. doi: 10.1177/0008417416648124
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement. Journal of School Psychology, 56, 133-142. doi: 10.1016/j.jsp.2016.04.001
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting Guideline in BEhavioural interventions (SCRIBE) 2016 statement. Journal of Clinical Epidemiology, 73, 142-152. doi: 10.1016/j.jclinepi.2016.04.006
Punja, Salima, Xu, Dongying, Schmid, Christopher H., Hartling, Lisa, Urichuk, Liana, Nikles, Catherine Jane and Vohra, Sunita (2016). N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis. Journal of Clinical Epidemiology, 76, 65-75. doi: 10.1016/j.jclinepi.2016.03.026
Nikles, Jane, Mitchell, Geoffrey K., Hardy, Janet, Senior, Hugh, Carmont, Sue-Ann, Schluter, Philip J., Vora, Rohan, Currow, David and Yelland, Michael (2016). Single patient multiple cross-over studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: a pilot study.. Palliative Medicine: a multiprofessional journal, 30 (8), 1-3. doi: 10.1177/0269216316635012
Punja, Salima, Shamseer, Larissa, Hartling, Lisa, Urichuk, Liana, Vandermeer, Ben, Nikles, Jane and Vohra, Sunita (2016). Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents (Review). Cochrane Database of Systematic Reviews, 2016 (2) CD009996. doi: 10.1002/14651858.CD009996.pub2
Punja, Salima, Schmid, Christopher H., Hartling, Lisa, Urichuk, Liana, Nikles, Catherine Jane and Vohra, Sunita (2016). To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD. Journal of Clinical Epidemiology, 76, 76-81. doi: 10.1016/j.jclinepi.2016.03.021
Mitchell, Geoffrey K., Hardy, Janet R., Nikles, Catherine J., Carmont, Sue-Ann S., Senior, Hugh E., Schluter, Philip J., Good, Philip and Currow, David C. (2015). The effect of methylphenidate on fatigue in advanced cancer: an aggregated n-of-1 trial. Journal of Pain and Symptom Management, 50 (3), 289-296. doi: 10.1016/j.jpainsymman.2015.03.009
Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David, Vohra, Sunita and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. Journal of Clinical Epidemiology, 76, 18-46. doi: 10.1016/j.jclinepi.2015.05.018
Vohra, Sunita, Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Tate, Robyn, Nikles, Jane, Zucker, Deborah R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. Journal of Clinical Epidemiology, 76, 9-17. doi: 10.1016/j.jclinepi.2015.05.004
Nikles, Jane, Mitchell, Geoffrey K., Hardy, Janet, Agar, Meera, Senior, Hugh Edgar John, Carmont, Sue-Ann, Schluter, Philip J., Good, Phillip, Vora, Rohan and Currow, David (2015). Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study. Palliative Medicine, 29 (10), 967-974. doi: 10.1177/0269216315585473
Vohra, Sunita, Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Tate, Robyn, Nikles, Jane, Zucker, Deborah R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. BMJ, 350 (may14 17) ARTN h1738, h1738-h1738. doi: 10.1136/bmj.h1738
Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David, Vohra, Sunita and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. BMJ, 350 (may14 15) ARTN h1793, h1793-h1793. doi: 10.1136/bmj.h1793
Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and Vohra, Sunita (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration. The BMJ, 350 h1793. doi: 10.1016/j.jclinepi.2015.05.018
Nikles, Catherine J., McKinlay, Lynne, Mitchell, Geoffrey K., Carmont, Sue-Ann S., Senior, Hugh E., Waugh, Mary-Clare A., Epps, Adrienne, Schluter, Philip J. and Lloyd, Owen T. (2014). Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury: a pilot study. Trials, 15 (54) 54, 1-11. doi: 10.1186/1745-6215-15-54
Nikles, Jane, Mitchell, Geoffrey K., Hardy, Janet, Agar, Meera, Senior, Hugh, Carmont, Sue-Ann, Schluter, Philip J., Good, Phillip, Vora, Rohan and Currow, David (2013). Do pilocarpine drops help dry mouth in palliative care patients: a protocol for an aggregated series of n-of-1 trials. BMC Palliative Care, 12 (39) 39, 1-15. doi: 10.1186/1472-684X-12-39
Senior, Hugh E. J., McKinlay, Lynne, Nikles, Jane, Schluter, Philip J., Carmont, Sue-Ann, Waugh, Mary-Clare, Epps, Adrienne, Lloyd, Owen and Mitchell, Geoffrey K. (2013). Central nervous system stimulants for secondary attention deficit-hyperactivity disorder after paediatric traumatic brain injury: a rationale and protocol for single patient (n-of-1) multiple cross-over trials. BMC Pediatrics, 13 (1) 89, 89.1-89.7. doi: 10.1186/1471-2431-13-89
Nikles, Jane and Harrison, Simone Lee (2013). An observational study of sun-protective behaviour at an outdoor spectator sporting event in a region of high sun exposure. Journal of Carcinogenesis and Mutagenesis. doi: 10.4172/2157-2518.S4-003
Senior, Hugh E. J., Mitchell, Geoffrey K., Nikles, Jane, Carmont, Sue-Ann, Schluter, Philip J., Currow, David C., Vora, Rohan, Yelland, Michael J., Agar, Meera, Good, Phillip D. and Hardy, Janet R. (2013). Using aggregated single patient (N-of-1) trials to determine the effectiveness of psychostimulants to reduce fatigue in advanced cancer patients: a rationale and protocol. BMC Palliative Care, 12 (1) 17, 17.1-17.6. doi: 10.1186/1472-684X-12-17
Harrison, Simone Lee, Nikles, Jane and Nowak, Madeleine (2013). Don’t burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy. Open Journal of Preventive Medicine, 3 (2), 212-218. doi: 10.4236/ojpm.2013.32029
Punja, Salima, Shamseer, Larissa, Hartling, Lisa, Urichuk, Liana, Vandermeer, Ben, Nikles, Catherine J. and Vohra, Sunita (2012). Amphetamines for Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents (Protocol). Cochrane Database of Systematic Reviews (7). doi: 10.1002/14651858.CD009996
Nikles, Jane, Lo, Victor, Giam, Jennifer A . and Saini, Bandana (2012). Exploring melatonin prescribing among customers of compounding pharmacies in Australia. Medical Journal of Australia, 196 (6), 384-385. doi: 10.5694/mja12.10145
Nikles, Jane, Mitchell, Geoffrey K., Schluter, Philip, Good, Phillip, Hardy, Janet, Rowett, Debra, Shelby-James, Tania, Vohra, Sunita and Currow, David (2011). Aggregating single patient (n-of-1) trials in populations where recruitment and retention was difficult: The case of palliative care. Journal of Clinical Epidemiology, 64 (5), 471-480. doi: 10.1016/j.jclinepi.2010.05.009
Hardy, Janet Rea, Carmont, Sue-Ann S., O'Shea, Angela, Vora, Rohan, Schluter, Philip, Nikles, Catherine Jane and Mitchell, Geoffrey Keith (2010). Pilot study to determine the optimal dose of methylphenidate for an n-of-1 trial for fatigue in patients with cancer. Journal of Palliative Medicine, 13 (10), 1193-1197. doi: 10.1089/jpm.2010.0185
Scuffham, Paul A., Nikles, Jane, Mitchell, Geoffrey K., Yelland, Michael J., Vine, Norma, Poulos, Christopher J., Pillans, Peter I., Bashford, Guy, del Mar, Chris, Schluter, Philip J. and Glasziou, Paul (2010). Using N-of-1 Trials to improve patient management and save costs. Journal of General Internal Medicine, 25 (9), 906-913. doi: 10.1007/s11606-010-1352-7
Nikles, Jane, Mitchell, Geoffrey K., Clavarino, Alexandra, Yelland, Michael J. and Del Mar, Christopher B. (2010). Stakeholders' views on the routine use of n-of-1 trials to improve clinical care and to make resource allocation decisions for drug use. Australian Health Review, 34 (1), 131-136. doi: 10.1071/AH09654
Nikles, J., Mitchell, G., Walters, J., Hardy, J., Good, P., Rowett, D., Shelby-James, T. and Currow, D. (2009). Prioritising drugs for single patient (n-of-1) trials in palliative care. Palliative Medicine, 23 (7), 623-634. doi: 10.1177/0269216309106461
Yelland, Michael J., Poulos, Christopher J., Pillans, Peter I., Bashford, Guy M., Nikles, Catherine Jane, Sturtevant, Joanna M., Vine, Norma, Del Mar, Christopher, Schluter, Philip J., Tan, Meng, Chan, Jonathon, Mackenzie, Fraser and Brown, Robyn (2009). N-of-1 Randomized Trials to Assess the Efficacy of Gabapentin for Chronic Neuropathic Pain. Pain Medicine, 10 (4), 754-761. doi: 10.1111/j.1526-4637.2009.00615.x
Scuffham, P. A., Yelland, M. J., Nikles, C. J., Pietrzak, E. and Wilkinson, D. (2008). Are N-of-1 trials an economically viable option to improve access to selected high cost medications? The Australian experience. Value in Health, 11 (1), 97-109. doi: 10.1111/j.1524-4733.2007.00218.x
Nikles, C. Jane, Mitchell, Geoffrey K., Del Mar, Chris B., McNairn, Norma and Clavarino, Alexandra (2007). Long-term changes in management following n-of-1 trials of stimulants in attention-deficit/hyperactivity disorder. European Journal of Clinical Pharmacology, 63 (11), 985-989. doi: 10.1007/s00228-007-0361-x
Yelland, M. J., Nikles, C. J., McNairn, N., Del Mar, C. B., Schluter, P. J. and Brown, R. M. (2007). Celecoxib compared with sustained release paracetamol for osteoarthritis: a series of n-of-1 trials. Rheumatology, 46 (1), 135-140. doi: 10.1093/rheumatology/kel195
Nikles, C. J., Mitchell, G. K., Del Mar, C. B., Clavarino, A. and McNairn, N. (2006). An n-of-1 trial service in clinical practice: Testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder. Pediatrics, 117 (6), 2040-2046. doi: 10.1542/peds.2005-1328
Nikles, C. J., Clavarino, A. M. and Del Mar, C. B. (2005). Using n-of-1 trials as a clinical tool to improve prescribing. British Journal Of General Practice, 55 (512), 175-180.
Nikles, C. J., Yelland, M., Glasziou, P. P. and Del Mar, C (2005). Do individualized medication effectiveness tests (N-of-1 trials) change clinical decisions about which drugs to use for osteoarthritis and chronic pain?. American Journal of Therapeutics, 12 (1), 92-97. doi: 10.1097/00045391-200501000-00012
Nikles, C. J., Yelland, M., Del Mar, C. and Wilkinson, D. (2005). The role of paracetamol in chronic pain: An evidence-based approach. American Journal of Therapeutics, 12 (1), 80-91. doi: 10.1097/00045391-200501000-00011
Coxeter, P. D., Schluter, P. J., Eastwood, H. L., Nikles, C. J. and Glasziou, P. P. (2003). Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-I trials. Complementary Therapies In Medicine, 11 (4), 215-222. doi: 10.1016/S0965-2299(03)00122-5
Najman, J. M., Williams, G. M., Nikles, J., Spence, S., Bor, W., O'Callaghan, M., Le Brocque, R., Andersen, M. J. and Shuttlewood, G. J. (2001). Bias Influencing Maternal Reports of Child Behaviour and Emotional State. Social Psychiatry and Psychiatric Epidemiology, 36 (4), 186-194. doi: 10.1007/s001270170062
Nikles, C. J., Glasziou, P. P., Del Mar, C. B., Duggan, C. M., Clavarino, A. M. and Yelland, M. J. (2000). Preliminary experiences with a single-patient trials service in general practice. Medical Journal of Australia, 173 (2), 100-103. doi: 10.5694/j.1326-5377.2000.tb139254.x
Najman, J. M., Williams, G. M., Nikles, J., Spence, S. H., Bor, W., O'Callaghan, M., Le Brocque, R. M. and Andersen, M.J. (2000). Mothers' mental illness and child behavior problems: Cause-effect association or observation bias. Journal of The American Academy of Child And Adolescent Psychiatry, 39 (5), 592-602. doi: 10.1097/00004583-200005000-00013
Duggan, C., Mitchell, G., Nikles, J., Glasziou, P. and Del Mar, C. (2000). Managing ADHD in general practice: N of 1 trials can help. Australian Family Physician, 29, 1205-1209.
Nikles, C. J., Glasziou, P. P., Del Mar, C. B., Duggan, C. and Mitchell, G. K. (2000). N of 1 trials: practical tools for medication management. Australian Family Physician, 29 (11), 1108-1112.
Duggan, C. M., Mitchell, G. K., Nikles, C. J., Glasziou, P. P., Del Mar, C. B. and Clavarino, A. M. (2000). Managing ADHD in general practice. N of 1 trials can help!. Australian Family Physician, 29 (12), 1205-1209.
Hardie, I. R., Moses, D. and Nikles, J. (1984). Infections in renal transplant recipients. Transplantation Proceedings, 16 (4), 988-989.
Conference Papers
Nikles, J., Johnston, A., van Driel, M., Perez, S., Ritchie, C., Elphinston, R. and Sterling, M. (2022). A systematic review of the effectiveness of interventions to improve opioid prescribing in ED for acute non-admitted musculoskeletal pain. Recover Injury Research Centre Conference, Brisbane, Australia, October 2022.
Nikles, J., Mitchell, G. K., Smith, S. S., McGree, J. M., McDonald, S., Poli, N., Senior, H., Tan, S., Dissanyaka, N., Ritchie, A. and O'Sullivan, J. D. (2021). Using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson’s Disease. Australian Clinical Trials Alliance conference, Sydney, NSW, Australia, November 2021.
McDonald, S., Pickering, G., McGree, J., Mitchell, G. and Nikles, J. (2021). Identified Personalised Patterns and Triggers of Fatigue in Multiple Sclerosis using Insights from Patient-Centred N-of-1 Observational Studies: A Protocol. Progress in MS Research Scientific Conference, Hobart, TAS, Australia, November 2021.
Ong, J., Nikles, J., Senior, H., Mitchell, G., Heussler, H. and McGree, J. (2021). N-of-1 Trials of Melatonin For Insomnia In Stimulant-Treated Children With ADHD (Poster and Abstract). UQ Medical Student research conference & showcase, Brisbane, QLD Australia, October 2021.
Hams, A., Evans, K., Sterling, M. and Nikles, J. (2021). A systematic review of N-of-1 studies in musculoskeletal physiotherapy. Australian Physiotherapy Association conference , Brisbane, Australia, October 2021.
McDonald, S. and Nikles, J. (2020). The Value of N-of-1 Clinical Trials and Single-Case Designs in Clinical Research. Herston Health Precinct Symposium, Brisbane, Australia, December 2020.
Heussler, H., Ong, J., Price, A., McGree, J., Mitchell, G., Senior, H. and Nikles, J. (2020). Comparison of parental expectations and clinical cut-off for improvement in sleep onset latency in children with ADHD on stimulants. Herston Health Precinct Symposium, Brisbane, QLD Australia, December 2020.
Nikles, J., Mitchell, G., Heussler, H., Price, A., McGree, J. and Ong, J. (2020). Melatonin for insomnia in children with attention deficit hyperactivity disorder (ADHD) on stimulants. Herston Health Precinct Symposium, Brisbane, QLD Australia, December 2020.
Ong, J., Nikles, J., Senior, H., Mitchell, G., Heussler, H. and McGree, J. (2020). N-Of-1 trials of melatonin for insomnia in stimulant-treated children with ADHD. UQ Medical Student research conference and showcase, Brisbane, QLD, Australia, October 2020.
Nikles, J., Khan, S., Leou, J., Ng, J., Bond, C., Nakamura, G., Le, R. and Sterling, M. (2019). A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury. Brispain, Brisbane, Australia, December 2019.
McDonald, S. and Nikles, J. (2019). N-of-1 Trials in Clinical Research: Opportunities and Challenges. ACTA International Clinical Trials Conference, Sydney, Australia, October 2019.
Neville, C., Beatty, E., Field, E., Pavey, T., Dawson, R., Nikles, J., Neville, E., Lindgren, A. and Banu, S. (2019). An aquatic exercise program to reduce behavioural and psychological symptoms in people with dementia: pilot study for a multi-centre, cluster-randomised, controlled trial. UQ Medical Student research conference, Brisbane, Australia, October 2019.
Ong, J., Nikles, J., Senior, H., Mitchell, G., Heussler, H. and McGree, J. (2019). Interim findings of the n-of-1 trials of melatonin for Insomnia in stimulant-treated children with ADHD. UQ Medical Student research conference and showcase, Brisbane, QLD Australia, October 2019.
McDonald, S., Tan, S., Banu, S., McGree, J., Mitchell, G. and Nikles, J. (2019). Understanding Symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome using Scientific Insights from N-of-1 Studies. Division of Health Psychology Annual conference, Manchester, United Kingdom, July 2019.
Nikles, J., Khan, S., Leou, J., Keizjers, G., Ng, J., Bond, C., Nakamura, G., Le, J., Le, R. and Sterling, M. (2019). A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury. . Australian Pain Society multidisciplinary conference, Gold Coast, QLD, Australia, April 2019.
McDonald, S., Tan, S., Banu, S., McGree, J., Mitchell, G. and Nikles, J. (2019). Using N-of-1 methods to identify patterns and predictors of ME/CFS symptom exacerbations. ME/CFS International Research Symposium., Geelong, VIC, Australia, March 2019.
Neville, C., Beatty, E., Field, E., Pavey, T., Dawson, R., Nikles, J., Neville, E., Lindgren, A. and Banu, S. (2018). An aquatic exercise program to reduce behavioural and psychological symptoms in people with dementia: pilot study for a multi-centre, cluster-randomised, controlled trial. UQ Medical Student research conference , Brisbane, QLD, Australia, 2018.
Tan, S., McDonald, S., McGree, J., Mitchell, G. and Nikles, J. (2018). Managing symptoms of ME/CFS using scientific insights from N-of-1 studies. CFS/ME International Conference , Gold Coast, QLD, Australia, 2018.
Alemayehu, C., Mitchell, G., Aseffa, A., Clavarino, A., McGree, J. and Nikles, J. (2018). N-of-1 therapeutic equivalence trial of two formulations of Enalapril in the treatment of hypertension in Ethiopia - Pilot study. Translational Research Institute, Brisbane, QLD, Australia, 2018.
Neville, C., Zamora, A., Neville, E., Nikles, J., Lindgren, A. and Ansari, S. (2018). A pilot aquatic exercise program to improve the health and wellbeing of people with dementia and their family carers. UQ medical student research conference , Brisbane, QLD, Australia, 2018.
Nikles, J., Khan, S., Leou, J., Keijzers, G., Ng, J., Bond, C., Nakamura, G., Le, R. and Sterling, M. (2018). A retrospective descriptive study of patients who presented to an Australian hospital emergency department with neck soft tissue injury. BrisPain Multidisciplinary conference, Brisbane, QLD, Australia, 6 December 2018.
Alemayehu, C., Mitchell, G. and Nikles, J. (2018). N-of-1 trials in the clinical care of patients in developing countries: a systematic review. 6th International Conference on Advanced Clinical Research and Clinical Trials, Zurich, Switzerland, 2018.
Nikles, J., Heussler, H., McGree, J., Senior, H., Melaku, M. and Mitchell, G. (2018). Melatonin for insomnia in stimulant-treated ADHD – the value of N-of-1 trials. UQCCR 10th Birthday, Brisbane, QLD Australia, 2018.
Nikles, J., Heussler, H. and McGree, J. (2018). Melatonin for insomnia in stimulant-treated ADHD – the value of N-of-1 trials. NHMRC Symposium on Research Translation, Sydney, NSW Australia, 2018.
Edelson, Jaclyn, Nikles, Jane, Byrnes, Josh, Heussler, Helen, Mitchell,Geoff and Melaku, Megdi (2018). Protocol for cost effectiveness analysis and longitudinal study of melatonin therapy in children with ADHD and sleep problems: an N-of-1 trial. Louisiana Chapter of the American College of Physicians meeting, Louisiana, United States, 2018.
Alemayehu, C., Mitchell, G., Aseffa, A., Nikles, J. and Clavarino, A. (2018). Acceptability and barriers to implementation of N-of-1 trials in a developing country: Ethiopia as a case study. 7th International Conference on Clinical Trials , Chicago, IL United States, 2018.
Alemayhu, Chalachew , Mitchell, Geoffrey , Nikles, Jane , Aseffa, Abraham , Clavarino, Alexandra and McGree, James (2017). N-of-1 therapeutic equivalence trial of two formulations of Enalapril in the treatment of hypertension, Ethiopia. PCRIS, Brisbane, Australia, 7-9 August 2017.
Bates, N., Emeto, T., Turner, D., Nikles, J. and Harrison, S. (2016). Sun protection provided by regulation school uniforms worn by primary school students in Queensland during summer. Townsville Health Research Week 2016: Spotlight on Preventative Health, Townsville, QLD, Australia, 12-15 September 2016.
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The single-case reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement. AOTA 96th Annual Conference and Expo, Chicag, Il, United States, 7-10 April 2016. Bethesda, MD, United States: American Occupational Therapy Associatio. doi: 10.5014/ajot.2016.704002
Agar, M., Lawlor, P., Caplan, G., Ely, E. W., Lam, L., de Souza, P. and Nikles, J. (2015). Randomised double blind placebo controlled phase II trial of melatonin for prevention of delirium in inpatients with advanced cancer. Australian Palliative Care Conference, Melbourne, VIC, Australia, 1-4 September 2015.
Mitchell, G., Nikles, J., Senior, H., Whitty, J., McGree, James, Carmont, S., Kravitz, R., Bazzano, L. and Schmid, C. (2015). Using individualized randomized trials to improve health outcomes and reduce costs. US-Australia Biomedical Research Partnership Conference, Canberra, ACT, Australia, 13 July 2015.
Mitchell, Geoff, Nikles, Jane, Carmont, Sue-Ann, Hardy, Janet, Good, Phillip, Agar, Meera, Clark, Katherine, Douglas, Carol, Vora, Rohan, Currow, David and Senior, H. (2013). Overview of N-of-1 study suite – lessons learned from three aggregated N-of-1 trials. PaCCSC 4th Annual Scientific Meeting and Research Forum 2013, Sydney, NSW, Australia, 20-21 Mar, 2013.
Harrison, Simone and Nikles, Jane (2012). Preliminary observations of hat wearing in Brisbane schools. Townsville Health Research Week, Townsville, QLD, Australia, 8 - 12 October 2012. Brisbane, QLD, Australia: Australasian College of Tropical Medicine.
Harrison, Simone and Nikles, Jane (2012). Don't burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy. Townsville Health Research Week, Townsville, QLD, Australia, 8 - 12 October 2012. Brisbane, QLD, Australia: Australasian College of Tropical Medicine.
Mitchell, Geoffrey, Hardy, Janet, Carmont, Sue-Ann, Nikles, Jane, Senior, Hugh, Schluter, Philip, Good, Philip, Agar, Meera, Clark, Katherine, Vora,Rohan, Douglas, Carol and Currow, David (2012). The effectiveness of methylphenidate in fatigue in advanced cancer: aggregated N-of-1 trails. Ipswich Hospital Research Day, Ipswich, Qld, Australia, 1 September 2012.
Harrison, Simone, Saunders, Vicki and Nikles, Jane (2012). Impact of the SunSmart Early Childhood Program in Queensland. Townsville Health Research Week, Townsville, QLD, Australia, 8 - 12 October 2012. Brisbane, QLD, Australia: Australasian College of Tropical Medicine.
Mitchell, G., Hardy, J., Carmont, S., Nikles, J., Senior, H., Schluter, P., Good, P., Agar, M., Clark, K., Vora, R. and Currow, D. (2012). The effectiveness of methylphenidate in fatigue in advanced cancer: Aggregated n-of-1 trial results. Australian and New Zealand Society of Palliative Medicine conference, Queenstown, New Zealand, 4 - 7 September 2012.
Saini, B., Lo, V., Giam, J. and Nikles, J. (2011). Exploring melatonin use among customers of compounding pharmacies in Australia. 23rd Annual Scientific Meeting of the Australasian Sleep Association and Australasian Sleep Technologists Association, Sydney, N.S.W., Australia, 27-29 October 2011. Oxford, England, U. K.: Wiley-Blackwell Publishing. doi: 10.1111/j.1365-2869.2011.00953.x
McKinlay, L., Lloyd, O., Nikles, J. and Mitchell, G. (2011). The use of stimulant medication in children with brain injury. Changed Lives, New pathways: A Conference on Children's Rehabilitation, Royal Children's Hospital, Herston QLD, Australia, 14 - 15 July 2011.
Carmont, S., Currow, D., Hardy, J., Mitchell, G. K., Nikles, J., Schluter, P., Vora, R. and Yelland, M. (2008). Investigating n-of-1 trials as a means of gathering palliative care evidence. 8th Biennial Conference of the Australian and New Zealand Society of Palliative Medicine (ANZSPM), Darwin, NT, Australia, 23-26 September 2008.
Mitchell, G., Nikles, J., Hardy, J., Currow, D., Good, P., Rowett, D. and Walters, J. (2007). Investigating the role of single patient trial as a means of gathering population level evidence in palliative care. Clinical Oncological Society of Australia 34th Annual Scientific Meeting, Adelaide, Australia, 14-16 November, 2007. Carlton, Australia: Blackwell Publishing. doi: 10.1111/j.1743-7563.2007.00127.x
Yelland, M. J., Nikles, J., McNairn, N. and Schluter, P. J. (2006). Single patient trials of gabapentin for chronic neuropathic pain. Australian Association of Musculoskeletal Medicine Annual Scientific Meeting, Canberra, Australia, 21-24 September 2006.
Yelland, Michael, Nikles, Jane, McNairn, Norma, Brown, Robyn, Del Mar, Christopher and Schluter, Philip (2006). Do n-of-1 trials of celeocxib compared to sustained release paracetamol change patient use of drugs for osteoarthritis?. RACGP 49th Annual Scientific Convention: Be the Future, Brisbane, QLD, Australia, 5-8 October 2006.
Yelland, Michael, Pietrzak, E,, Schluter, Philip, Nikles, Jane and Wilkinson, D. (2006). Could N-of-1 trials make prescribing more cost-effective?. RACGP 49th Annual Scientific Convention: Be the Future, Brisbane, QLD, Australia, 5-8 October 2006.
Yelland, Michael, Pietrzak, Eva, Scuffham, Paul, Nikles, Jane and Wilkinson, David (2006). Could N-of-1 trials make prescribing more cost-effective?. 2006 GP & PHC Research Conference: Optimising Impact, Perth, WA, Australia, 5-7 July 2006.
Nikles, J., Pietrzak, E., Scuffham, P., Wilkinso, D. and Yelland, M. (2006). Could n-of-1 trials make prescribing more cost effective?. RACGP 49th Annual Scientific Convention: Be the Future, Brisbane, QLD, Australia, 5-8 October 2006.
Christopher Poulos, Guy Bashford, Michael Yelland, Jane Nikles, Norma McNairn and Nancy Fish (2006). Single patient trials of gabapentin - the experience from a pain clinic. Australian Faculty of Rehabilitation Medicine 14th Annual Scientific Meeting, Cairns, Australia, 2006.
Yelland, M., Nikles, J., McNairn, N., Glasziou, P. and Glasziou, C. (2005). Single patient trials comparing NSAIDs with paracetamol for osteoarthritis and chronic pain. Australian Association of Musculoskeletal Medicine Conference, Singapore, 2005.
Yelland, M., Nikles, J., McNairn, N., Glasziou, P. and Del Mar, C. (2005). Single patient trials comparing NSAIDs with paracetamol for osteoarthritis and chronic pain. Australian Association of Musculoskeletal Medicine Conference - Pain Management in the Elderly, Noosa, Australia, 3-7 March 2005.
Yelland, M. J., Nikles, C. J. and McNairn, N. (2005). Single patient trials of gabapentin for chronic neuropathic pain. 11th IASP World Congress on Pain, Sydney, NSW, Australia, 21-26 August 2005. Seattle, WA, United States: IASP Press.
Yelland, M., Nikles, J., Glasziou, P., Del Mar, C., Pillans, P. and Sturtevant, J. (2004). Individual Medication Effectiveness Tests (IMETs) to assess the efficacy of gabapentin in individual patients with chronic neuropathic pain. 25th Annual Scientific Meeting of the Australian Pain Society, Canberra, Australia, 7-10 March 2004.
Nikles, C.J., Yelland, M., Glasziou, P., Del Mar, C., Pillans, P. and Sturtevant, J. (2004). Do individualised medication effectiveness tests improve decisions about which drugs to use for osteoarthritis or chronic pain?. 25th Annual Scientific Meeting of the Australian Pain Society, Canberra, Australia, 7-10 March 2004.
Mitchell, G., Del Mar, C., Glasziou, P. and Nikles, J. (2003). N of 1 trials: individualizing the evidence. The Australasian Pharmaceutical Science Association Annual Conference, Sydney, 3-5 December 2003.
Nikles, J., Yelland, M., Glasziou, P. and Del Mar, C. (2003). Do individualised medication effectiveness tests improve decisions about which drugs to use for osteoarthritis or chronic pain?. Queensland Health Research Conference, Brisbane, QLD, Australia, 2003.
Yelland, M., Nikles, J., Glasziou, P., Del Mar, C., Pillans, P. and Sturtevant, J. (2003). Individual medication effectiveness tests (IMETs) to assess the efficacy of gabapentin in individual patients with chronic neuropathic pain. Queensland Health Research Conference, Brisbane, QLD, Australia, 2003.
Mitchell, G. K., Nikles, C. J., Glasziou, P. P., Steer, P. and Jenkins-Manning, S. (2002). Targeting stimulants to responders: Individual Medication Effectiveness Tests for Attention Deficit Hyperactivity Disorder. Queensland Health and Medical Scientific Meeting, Brisbane, Australia, 4-5 December, 2002. Brisbane: Centre for Palliative Care.
Mitchell, G. K., Nikles, C.J., Glasziou, P. P., Del Mar, C. B. and Schluter, P. J. (2002). Individual medication effectiveness tests of stimulants in the treatment of attention deficit hyperactivity disorder. General Practice and Primary Health Care Conference, Melbourne, VIC, Australia, 29-31 May 2002. Melbourne VIC, Australia: Primary Health Care Research Care & Information Services, DHAC.
Mitchell, G., Nikles, J., Glasziou, P., Del Mar, C. and Schluter, P. (2002). Individual medication effectiveness tests of stimulants in the treatment of Attention Deficit Hyperactivity Disorder. Quality Use of Medicines Conference, Canberra, ACT, Australia, 2002.
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Mitchell, G., O'Connor, V., Price, J., Yelland, M., Coxeter, P., Askew, D., Janamian, T., Spinks, A., Clavarino, A. and Schluter, P. (2002). Research as practice: using individualised medication effectiveness tests to improve prescribing. Quality Use of Medicines Conference, Canberra ACT, Australia, 2002.
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Mitchell, G., O'Connor, V., Price, J., Yelland, M., Coxeter, P., Askew, D., Janamian, T., Spinks, A., Clavarino, A. and Schluter, P. (2002). Research as practice: using individualised medication effectiveness tests to improve prescribing. General Practice and Primary Health Care conference, Melbourne VIC, Australia, 29-31 May 2002.
Yelland, M. J., Beller, E., Nikles, J. and Glasziou, P. (2002). Achieving good compliance and followup in clinical trials. Australian Association of Academic General Practice Research Meeting, Melbourne, VIC, Australia, 29-31 May 2002. Adelaide, South Australia: Primary Health Care Research and Information Service.
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Yelland, M. and King, J. (2002). Individualised medication effectiveness tests may improve osteoarthritis management and decrease NSAID expenditure. General Practice and Primary Health Care conference, Melbourme, VIC, Australia, 29-31 May 2002.
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Yelland, M. and King, J. (2002). Individualised medication effectiveness tests may improve osteoarthritis management and decrease NSAID expenditure. Quality Use of Medicines Conference, Canberra ACT, Australia, 2002.
Mitchell, G. K., Duggan, C. M., Glasziou, P. P., Del Mar, C. B., Nikles, J.C.J., Janamian, T. and Schluter, P. J. (2001). Individualised Medication Effectiveness Tests to better manage ADHD. 2001 General Practice and Primary Health Care Research Conf, Canberra, 31 May - 1 June 2001. Canberra: Primary Health Care Research & Information Service.
Nikles, J., Coxeter, P., Price, J., Duggan, C., Glasziou, P., Del Mar, C. and Schluter, P. (2001). Individualised medication effectiveness tests of valerian for chronic insomnia. General Practice Evaluation Program Conference, Adelaide, South Australia, 2001.
Nikles, J., Duggan, C., Glasziou, P., Del Mar, C. and Yelland, M. (2001). Individualised medication effectiveness tests may improve OA management and decrease NSAID expenditure. General Practice Evaluation Program Conference, Adelaide, South Australia, 2001.
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Mitchell, G., O'Connor, V., Price, J., Yelland, M., Coxeter, P., Askew, D., Janamian, T., Spinks, A., Clavarino, A. and Schluter, P. (2001). Research as practice: using Individualised medication effectiveness tests to improve prescribing. General Practice and Primary Health Care conference, Brisbane, QLD, Australia, 2001.
Nikles, J.C.J., Duggan, C. M., Glasziou, P. P., Del Mar, C. B. and Yelland, M. J. (2001). Individualised medication effectiveness tests may improve OA management and decrease NSAID expenditure. General Practice & Primary Health Care Research Conference, Adelaide, South Australia, 31 May - 1 June 2001. Adelaide, South Australia:
Nikles, J.C.J., Duggan, C. M., Glasziou, P. P., Del Mar, C. B., Coxeter, P.D., Askew, D. A., Janamian, T., Spinks, A. B., Clavarino, A. M., Mitchell, G. K., O'Connor, V. M., Price, J., Yelland, M. J. and Schluter, P. J. (2001). Research as practice: using Individialised Medication Effectiveness tests to improve prescribing. 2001 General Practice and Primary Health Care Research Conference & Australian Association of Academic General Practice Research Meeting 2001, Canberra, 31 May - 1 June 2001. Canberra: Primary Health Care Research & Information Service.
Mitchell, G., Duggan, C., Glasziou, P., Del Mar, C., Nikles, J., Janamian, T. and Schluter, P (2001). Individualised medication effectiveness tests to better manage ADHD. General Practice Evaluation Program Conference, Adelaide, South Australia, 2001.
O'Connor, V., Askew, D., Spinks, A., Nikles, J., Duggan, C., Del Mar, C. and Glasziou, P. (2001). Do psychological menopausal symptoms respond to HRT? Individualised medication effectiveness tests as an applied research tool. General Practice Evaluation Program Conference, Adelaide, South Australia, 2001.
Nikles, J., Duggan, C., Glasziou, P., Del Mar, C., Coxeter, P., Askew, D., Janamian, T., Spinks, A., Clavarino, A., Mitchell, G., O'Connor, V., Price, J., Yelland, M. and Schluter, P. (2001). Research as practice: using individualised medication effectiveness tests to improve prescribing. General Practice Evaluation Program Conference, Adelaide, SA, Australia, 2001.
Nikles, J.C.J., Coxeter, P.D., Price, J., Duggan, C. M., Glasziou, P. P., Del Mar, C. B. and Schluter, P. J. (2001). Individualised medication effectiveness tests of valerian for chronic insomnia. General Practice & Primary Health Care Research Conference, Adelaide, South Australia, 31 May - 1 June 2001. Adelaide, South Australia:
O'Connor, V. M., Askew, D. A., Spinks, A. B., Nikles, J.C.J., Duggan, C. M., Del Mar, C. B. and Glasziou, P. P. (2001). Do psychological menopausal symptoms respond to HRT Individualised Medication Effectiveness Tests as an applied research tool. General Practice & Primary Health Care Research Conference, Adelaide, Australia, 31 May - 1 June 2001. Adelaide:
Mitchell, G. K., Nikles, C. J., Glasziou, P. P. and Schluter, P. J. (2000). Single patient trials of stimulants in Attention Deficit Hyperactivity Disorder. General Practice Evaluation Conference, Flinders University, Adelaide, Australia, 2000. Adelaide: Flinders University.
Mitchell, G. K., Nikles, C. J., Glasziou, P. P. and Schluter, P. J. (2000). Single patient trials of stimulants in Attention Deficit Hyperactivity Disorder - a pilot study. 29th Annual Scientific Meeting Association of University Departments of General Practice, Bournemouth, England., 2000. England: Association of University Departments of General Practice.
Mitchell, G. K., Glasziou, P. P. and Nikles, C. J. (2000). Single patient trials in the treatment of ADHD in General Practice - a pilot study. 6th European Conference on General Practice and Family Medicine, Vienna; Hafburg Conference Centre, Vienna, 2-6 July 2000. Vienna: WONCA.
Mitchell G, Nikles, J., Glasziou, P. and Schluter P. (2000). Individualised medication effectiveness tests of stimulants in Attention Deficit Hyperactivity Disorder. General Practice Evaluation Program Conference, Hobart , TAS, Australia, 2000.
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Clavarino, A. and Yelland, M. (2000). Is a individualised medication effectiveness tests service feasible in general practice? Preliminary experiences. General Practice Evaluation Program Conference, Hobart , TAS, Australia, 2000.
Nikles, J., Del Mar, C., Glasziou, P., Clavarino, A. and Duggan, C. (2000). Consumer perspectives of individualised medication effectiveness tests in General Practices. General Practice Evaluation Program Conference, Hobart , TAS, Australia, 2000.
Glasziou, P. P., Del Mar, C. B., Nikles, C. J. and Duggan, C. M. (2000). Preliminary experience with single patient trials in general practice. The 2000 General Practice Evaluation Program, Hobart, 2000. Canberra: National Information Service.
Clavarino, A. M., Del Mar, C. B., Duggan, C. M., Glasziou, P. P. and Nikles, C. J. (2000). Consumer perspectives of single patient trials in general practice. The General Practice Evaluation Program, Hobart: Hotel Grand Chancellor, 4-5 May 2000. Canberra: National Information Service.
Mitchell, G. K., Nikles, C. J., Glasziou, P. P. and Schluter, P. J. (2000). Single patient trials of stimulants in attention deficit hyperactivity disorder. The General Practice Evaluation Program, Hobart, 2000. Canberra: National Information Service.
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Askew, D., Janamian, T. and Coxeter, P. (2000). Individualised medication effectiveness tests service: feasibility in general practice. RACGP 43rd Annual Scientific Convention, Townsville, QLD, Australia, 2000.
Mitchell, G., Nikles, J., Glasziou, P. and Schluter, P. (2000). Single patient trials of stimulants in Attention Deficit Hyperactivity Disorder - a pilot study. 6th European Wonca Conference on General Practice & Family Doctors, Hafburg Conference Centre, Vienna, 2 - 6 July 2000. Euopean WONCA.
Nikles, J., Glasziou, P. and Del Mar, C. (1999). Individualised medication effectiveness tests in general practice. General Practice Evaluation Program Conference, Brisbane, QLD, Australia, 1999.
Nikles, C. J., Glasziou, P. P. and Del Mar, C. B. (1999). Single patient trials in general practice. General Practice Evaluation Program Conference, Sheraton, Brisbane, 6-7 May 1999. Bedford Park SA: Flinders Uni.
Moses, Diana, Nikles, Jane, Leong, Geoff and Hardie, Ian (1983). Infections in renal transplant recipients. Meeting of the Surgical Research Society of Australasia, Perth, Western Australia, 14-16 October 1982. Richmond, VIC, Australia: Wiley-Blackwell Publishing. doi: 10.1111/j.1445-2197.1983.tb02463.x
Thesis
Nikles, Jane (2006). Using n-of-1 trials as a diagnostic clinical tool. PhD Thesis, Population Health, The University of Queensland.
Research Reports
Clark, R., Del Mar, C. B., Mitchell, G. K., Nikles, C. J., Scuffham, P. and Yelland, M. (2006). An economic evaluation of n-of-1 trials in clinical practice : Final report. Canberra, ACT, Australia: Australian Health Ministers Advisory Council.
Mitchell, G. K., Nikles, C.J., Duggan, C., Glasziou, P. P. and Del Mar, C. B. (2002). Individualised Medical Effectivenss Tests comparing Dexamphetamine or Methylphenidate with placebo for the treatment of Attention- Deficit Hyperactivity Disorder in General Practice. Australia: University of Queensland.