Dr Roberta Littleford
Clinical Trials Research Specialist
UQ Centre for Clinical Research
+61 7 334 65046
Journal Articles
Witham, Miles D., Lees, Jennifer S., White, Myra, Band, Margaret, Bell, Samira, Chantler, Donna J., Ford, Ian, Fulton, Roberta L., Kennedy, Gwen, Littleford, Roberta C., McCrea, Ian V., McGlynn, Deborah, Panarelli, Maurizio, Ralston, Maximilian R., Rutherford, Elaine, Severn, Alison, Thomson, Nicola, Traynor, Jamie P., Struthers, Allan D., Wetherall, Kirsty and Mark, Patrick B. (2020). Vitamin K supplementation to improve vascular stiffness in CKD: The K4Kidneys randomized controlled trial. Journal of the American Society of Nephrology, 31 (10), 2434-2445. doi: 10.1681/ASN.2020020225
Young, Ben, Bedford, Laura, das Nair, Roshan, Gallant, Stephanie, Littleford, Roberta, Robertson, John F.R., Schembri, Stuart, Sullivan, Frank M., Vedhara, Kavita and Kendrick, Denise (2020). Unconditional and conditional monetary incentives to increase response to mailed questionnaires: a randomized controlled study within a trial (SWAT). Journal of Evaluation in Clinical Practice, 26 (3), 893-902. doi: 10.1111/jep.13230
Witham, Miles D., Band, Margaret, Chong, Huey, Donnan, Peter T., Hampson, Geeta, Hu, May Khei, Littleford, Roberta, Lamb, Edmund, Kalra, Philip A., Kennedy, Gwen, McNamee, Paul, Plews, Deirdre, Rauchhaus, Petra, Soiza, Roy L., Sumukadas, Deepa, Warwick, Graham and Avenell, Alison (2020). Sodium bicarbonate to improve physical function in patients over 60 years with advanced chronic kidney disease: the BiCARB RCT. Health Technology Assessment, 24 (27), 1-89. doi: 10.3310/hta24270
Witham, Miles D., Band, Margaret, Ahmed, Aimun, Almond, Michael K., Balasubramaniam, Gowrie, Basnayake, Kolitha, Bhatnagar, Deepak, Chan, Anthony, Chong, Huey Yi, Donnan, Peter T., Duncan, Neill, Hampson, Geeta, Hu, May Khei, Kalra, Philip A., Kennedy, Gwen, Kirk, Adam, Lamb, Edmund J., Lambie, Stewart, Littleford, Roberta, McNamee, Paul, Mishra, Biswa, Mitra, Sandip, Nicholas, Johann, Plews, Deirdre, Rauchhaus, Petra, Soiza, Roy L., Stevens, Paul E., Sumukadas, Deepa, Tse, Wai ... Avenel, Alison (2020). Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): a pragmatic randomised, double-blind, placebo-controlled trial. BMC Medicine, 18 (1) 91. doi: 10.1186/s12916-020-01542-9
Robertson, John F.R., Coleman, Robert E., Cheung, Kwok-Leung, Evans, Abigail, Holcombe, Chris, Skene, Anthony, Rea, Daniel, Ahmed, Samreen, Jahan, Ali, Horgan, Kieran, Rauchhaus, Petra, Littleford, Roberta, Amy Cheung, S. Y., Cullberg, Marie, de Bruin, Elza C., Koulai, Loumpiana, Lindemann, Justin P. O., Pass, Martin, Rugman, Paul, Schiavon, Gaia, Deb, Rahul, Finlay, Pauline, Foxley, Andrew and Gee, Julia M.W. (2020). Proliferation and AKT activity biomarker analyses after capivasertib (AZD5363) treatment of patients with ERþ invasive breast cancer (STAKT). Clinical Cancer Research, 26 (7), 1574-1585. doi: 10.1158/1078-0432.CCR-19-3053
Treweek, Shaun, Bevan, Simon, Bower, Peter, Briel, Matthias, Campbell, Marion, Christie, Jacquie, Collett, Clive, Cotton, Seonaidh, Devane, Declan, El Feky, Adel, Galvin, Sandra, Gardner, Heidi, Gillies, Katie, Hood, Kerenza, Jansen, Jan, Littleford, Roberta, Parker, Adwoa, Ramsay, Craig, Restrup, Lynne, Sullivan, Frank, Torgerson, David, Tremain, Liz, Von Elm, Erik, Westmore, Matthew, Williams, Hywel, Williamson, Paula R. and Clarke, Mike (2020). Trial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed. Trials, 21 (1) 33, 33. doi: 10.1186/s13063-019-3980-5
Clark, Marcia E., Young, Ben, Bedford, Laura E., das Nair, Roshan, Robertson, John F. R., Vedhara, Kavita, Sullivan, Francis, Mair, Frances S., Schembri, Stuart, Littleford, Roberta C. and Kendrick, Denise (2019). Lung cancer screening: does pulmonary nodule detection affect a range of smoking behaviours?. Journal of Public Health, 41 (3), 600-608. doi: 10.1093/pubmed/fdy158
Cumming, Sarah A., Jimenez-Moreno, Cecilia, Okkersen, Kees, Wenninger, Stephan, Daidj, Ferroudja, Hogarth, Fiona, Littleford, Roberta, Gorman, Gráinne, Bassez, Guillaume, Schoser, Benedikt, Lochmüller, Hanns, van Engelen, Baziel G.M. and Monckton, Darren G. (2019). Genetic determinants of disease severity in the myotonic dystrophy type 1 OPTIMISTIC cohort. Neurology, 93 (10), e995-e1009. doi: 10.1212/wnl.0000000000008056
Flower, Michael, Lomeikaite, Vilija, Ciosi, Marc, Cumming, Sarah, Morales, Fernando, Lo, Kitty, Hensman Moss, Davina, Jones, Lesley, Holmans, Peter, Monckton, Darren G., Tabrizi, Sarah J, Kraus, Peter, Hoffman, Rainer, Tobin, Alan, Borowsky, Beth, Keenan, S, Whitlock, Kathryn B., Queller, Sarah, Campbell, Colin, Wang, Chiachi, Langbehn, Doug, Axelson, Eric, Johnson, Hans, Acharya, Tanka, Cash, Dave M., Frost, Chris, Jones, Rebecca, Jurgens, Caroline, Hart, Ellen P. T. ... Merkies, Ingemar (2019). MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1. Brain, 142 (7), 1876-1886. doi: 10.1093/brain/awz115
Young, Ben, Vedhara, Kavita, Kendrick, Denise, Littleford, Roberta, Robertson, John F. R., Sullivan, Frank M., Schembri, Stuart and Das Nair, Roshan (2018). Determinants of motivation to quit in smokers screened for the early detection of lung cancer: a qualitative study. BMC Public Health, 18 (1) 1276. doi: 10.1186/s12889-018-6211-1
Clark, Marcia E., Bedford, Laura E., Young, Ben, Robertson, John F. R., das Nair, Roshan, Vedhara, Kavita, Littleford, Roberta, Sullivan, Francis M., Mair, Frances S., Schembri, Stuart, Rauchhaus, Petra and Kendrick, Denise (2018). Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules. Lung Cancer, 124, 160-167. doi: 10.1016/j.lungcan.2018.08.001
Parker, Adwoa, Knapp, Peter, Treweek, Shaun, Madhurasinghe, Vichithranie, Littleford, Roberta, Gallant, Stephanie, Sullivan, Frank, Schembri, Stuart, Rick, Jo, Graffy, Jonathan, Collier, David J., Eldridge, Sandra, Kennedy, Anne and Bower, Peter (2018). The effect of optimised patient information materials on recruitment in a lung cancer screening trial: an embedded randomised recruitment trial 11 Medical and Health Sciences 1117 Public Health and Health Services. Trials, 19 (1) 503. doi: 10.1186/s13063-018-2896-9
Okkersen, Kees, Jimenez-Moreno, Cecilia, Wenninger, Stephan, Daidj, Ferroudja, Glennon, Jeffrey, Cumming, Sarah, Littleford, Roberta, Monckton, Darren G, Lochmüller, Hanns, Catt, Michael, Faber, Catharina G, Hapca, Adrian, Donnan, Peter T, Gorman, Gráinne, Bassez, Guillaume, Schoser, Benedikt, Knoop, Hans, Treweek, Shaun, van Engelen, Baziel G M, Kierkegaard, Marie, Okkersen, Kees, Jimenez-Moreno, Cecilia, Wenninger, Stephan, Daidj, Ferroudja, Cumming, Sarah, Littleford, Roberta, Monckton, Darren, Lochmüller, Hanns, Catt, Michael ... Dittrich, Juliane (2018). Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial. The Lancet Neurology, 17 (8), 671-680. doi: 10.1016/S1474-4422(18)30203-5
Lambert, Matthew A., Weir-McCall, Jonathan R., Salsano, Marco, Gandy, Stephen J., Levin, Daniel, Cavin, Ian, Littleford, Roberta, MacFarlane, Jennifer A., Matthew, Shona Z., Nicholas, Richard S., Struthers, Allan D., Sullivan, Frank, Henderson, Shelley A., White, Richard D., Belch, Jill J. F. and Graeme Houston, J. (2018). Prevalence and distribution of atherosclerosis in a low- to intermediate-risk population: assessment with whole-body MR angiography. Radiology, 287 (3), 795-804. doi: 10.1148/radiol.2018171609
Treweek, Shaun, Bevan, Simon, Bower, Peter, Campbell, Marion, Christie, Jacquie, Clarke, Mike, Collett, Clive, Cotton, Seonaidh, Devane, Declan, El Feky, Adel, Flemyng, Ella, Galvin, Sandra, Gardner, Heidi, Gillies, Katie, Jansen, Jan, Littleford, Roberta, Parker, Adwoa, Ramsay, Craig, Restrup, Lynne, Sullivan, Frank, Torgerson, David, Tremain, Liz, Westmore, Matthew and Williamson, Paula R. (2018). Trial Forge guidance 1: what is a Study Within A Trial (SWAT)?. Trials, 19 (1) 139. doi: 10.1186/s13063-018-2535-5
Weir-McCall, Jonathan R., Lambert, Matthew, Gandy, Stephen J., Belch, Jill J. F., Cavin, Ian, Henderson, Shelley A., Littleford, Roberta, MacFarlane, Jennifer A., Matthew, Shona Z., Stephen Nicholas, R., Struthers, Allan D., Sullivan, Frank, White, Richard D. and Graeme Houston, J. (2018). Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study. Journal of Cardiovascular Magnetic Resonance, 20 (1) 7. doi: 10.1186/s12968-018-0428-0
Treweek, Shaun and Littleford, Roberta (2018). Trial management - building the evidence base for decision-making. Trials, 19 (1) 11. doi: 10.1186/s13063-017-2322-8
Casanova, F., Adingupu, D. D., Adams, F., Gooding, K. M., Looker, H. C., Aizawa, K., Dove, F., Elyas, S., Belch, J. J.F., Gates, P. E., Littleford, R. C., Gilchrist, M., Colhoun, H. M., Shore, A. C., Khan, F. and Strain, W. D. (2017). The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control. Cardiovascular Diabetology, 16 (1) 114. doi: 10.1186/s12933-017-0594-7
Weir-McCall, Jonathan R., Fitzgerald, Kerrie, Papagiorcopulo, Carla J., Gandy, Stephen J., Lambert, Matthew, Belch, Jill J. F., Cavin, Ian, Littleford, Roberta, Macfarlane, Jennifer A., Matthew, Shona Z., Nicholas, R. Stephen, Struthers, Allan D., Sullivan, Frank M., Waugh, Shelley A., White, Richard D. and Houston, J. Graeme (2017). Prevalence of unrecognizedmyocardial infarction in a low-intermediate risk asymptomatic cohort and its relation to systemic atherosclerosis. European Heart Journal Cardiovascular Imaging, 18 (6), 657-662. doi: 10.1093/ehjci/jew155
Weir-McCall, Jonathan R., Yeap, Phey Ming, Papagiorcopulo, Carla, Fitzgerald, Kerrie, Gandy, Stephen J., Lambert, Matthew, Belch, Jill J.F., Cavin, Ian, Littleford, Roberta, Macfarlane, Jennifer A., Matthew, Shona Z., Nicholas, R. Stephen, Struthers, Allan D., Sullivan, Frank, Henderson, Shelley A., White, Richard D. and Houston, J. Graeme (2017). Reply: the enigma of left ventricular non-compaction. Journal of the American College of Cardiology, 69 (19), 2470-2471. doi: 10.1016/j.jacc.2017.02.062
Sullivan, F. M., Farmer, Eoghan, Mair, Frances S., Treweek, Shaun, Kendrick, Denise, Jackson, Cathy, Robertson, Chris, Briggs, Andrew, McCowan, Colin, Bedford, Laura, Young, Ben, Vedhara, Kavita, Gallant, Stephanie, Littleford, Roberta, Robertson, John, Sewell, Herb, Dorward, Alistair, Sarvesvaran, Joseph and Schembri, Stuart (2017). Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial. BMC Cancer, 17 (1) 187. doi: 10.1186/s12885-017-3175-y
Weir-McCall, Jonathan R., Yeap, Phey Ming, Papagiorcopulo, Carla, Fitzgerald, Kerrie, Gandy, Stephen J., Lambert, Matthew, Belch, Jill J.F., Cavin, Ian, Littleford, Roberta, Macfarlane, Jennifer A., Matthew, Shona Z., Nicholas, R. Stephen, Struthers, Allan D., Sullivan, Frank, Waugh, Shelley A., White, Richard D. and Houston, J. Graeme (2016). Left ventricular noncompaction: anatomical phenotype or distinct cardiomyopathy?. Journal of the American College of Cardiology, 68 (20), 2157-2165. doi: 10.1016/j.jacc.2016.08.054
Gandy, Stephen J., Lambert, Matthew, Belch, Jill, Cavin, Ian, Crowe, Elena, Littleford, Roberta, MacFarlane, Jennifer A., Matthew, Shona Z., Martin, Patricia, Nicholas, R. Stephen, Struthers, Allan, Sullivan, Frank, Waugh, Shelley A., White, Richard D., Weir-McCall, Jonathan R. and Houston, J. Graeme (2016). 3T MRI investigation of cardiac left ventricular structure and function in a UK population: the tayside screening for the prevention of cardiac events (TASCFORCE) study. Journal of Magnetic Resonance Imaging, 44 (5), 1186-1196. doi: 10.1002/jmri.25267
McMurdo, Marion E. T., Sumukadas, Deepa, Donnan, Peter T., Cvoro, Vera, Rauchhaus, Petra, Argo, Ishbel, Waldie, Helen, Littleford, Roberta, Struthers, Allan D. and Witham, Miles D. (2016). Spironolactone for people age 70 years and older with osteoarthritic knee pain: a proof-of-concept trial. Arthritis Care and Research, 68 (5), 716-721. doi: 10.1002/acr.22724
Weir-Mccall, Jonathan R., Cassidy, Deirdre B., Belch, Jill J. F., Gandy, Stephen J., Houston, J. G., Lambert, Matthew A., Littleford, Roberta C., Rowland, Janice, Struthers, Allan D. and Khan, Faisel (2016). Whole-body cardiovascular MRI for the comparison of atherosclerotic burden and cardiac remodelling in healthy South Asian and European adults. British Journal of Radiology, 89 (1065) 20160342, 20160342. doi: 10.1259/bjr.20160342
Witham, Miles D., Band, Margaret M., Littleford, Roberta C., Avenell, Alison, Soiza, Roy L., McMurdo, Marion E. T., Sumukadas, Deepa, Ogston, Simon A., Lamb, Edmund J., Hampson, Geeta and McNamee, Paul (2015). Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis (the BiCARB trial)? Study protocol for a randomized controlled trial. Trials, 16 (1) 326. doi: 10.1186/s13063-015-0843-6
Treweek, Shaun, Altman, Doug G., Bower, Peter, Campbell, Marion, Chalmers, Iain, Cotton, Seonaidh, Craig, Peter, Crosby, David, Davidson, Peter, Devane, Declan, Duley, Lelia, Dunn, Janet, Elbourne, Diana, Farrell, Barbara, Gamble, Carrol, Gillies, Katie, Hood, Kerry, Lang, Trudie, Littleford, Roberta, Loudon, Kirsty, McDonald, Alison, McPherson, Gladys, Nelson, Annmarie, Norrie, John, Ramsay, Craig, Sandercock, Peter, Shanahan, Daniel R., Summerskill, William, Sydes, Matt ... Clarke, Mike (2015). Making randomised trials more efficient: Report of the first meeting to discuss the Trial Forge platform. Trials, 16 (1) 261. doi: 10.1186/s13063-015-0776-0
Gandy, S. J., Lambert, M., Belch, J. J.F., Cavin, I. D., Crowe, E., Littleford, R., Macfarlane, J. A., Matthew, S. Z., Martin, P., Nicholas, R. S., Struthers, A. D., Sullivan, F., Waugh, S. A., White, R. D., Weir-Mccall, J. R. and Houston, J. G. (2015). Technical assessment of whole body angiography and cardiac function within a single MRI examination. Clinical Radiology, 70 (6), 595-603. doi: 10.1016/j.crad.2015.02.003
van Engelen, Baziel, Abghari, Shaghayegh, Aschrafi, Armaz, Bouman, Sachas, Cornelissen, Yvonne, Glennon, Jeffrey, Groot, Perry, Heerschap, Arend, Heskamp, Linda, Heskes, Tom, Kapusta, Katarzyna, Klerks, Ellens, Knoop, Hans, Maas, Daphnes, Okkersen, Kees, Poelmans, Geert, Rahmadi, Ridho, van Nimwegen, Marlies, Gorman, Grainne, Moreno, Cecilia Jimenez, Lochmüller, Hanns, Trenell, Mike, van Laar, Sandra, Wood, Libby, Schoser, Benedikt, Wenninger, Stephan, Schüller, Angela, Auguston, Rémie, Baptiste, Lignier ... Treweek, Shaun (2015). Cognitive behaviour therapy plus aerobic exercise training to increase activity in patients with myotonic dystrophy type 1 (DM1) compared to usual care (OPTIMISTIC): study protocol for randomised controlled trial. Trials, 16 (1) 224. doi: 10.1186/s13063-015-0737-7
Green, F. C., Levison, R., Newton, D. J., Littleford, R., Stonebridge, P. A. and Belch, J. J.F. (2012) Detecting diabetes and impaired glucose tolerance in patients with atherosclerotic peripheral arterial disease. International Angiology, 31 2: 125-128.
Littleford, Roberta C., Khan, Faisel and Belch, Jill J. F. (1999). Impaired skin vasomotor reflexes in patients with erythromelalgia. Clinical Science, 96 (5), 507-512. doi: 10.1042/CS19980341
Littleford, R. C., Khan, F. and Belch, J. J.F. (1999). Skin perfusion in patients with erythromelalgia. European Journal of Clinical Investigation, 29 (7), 588-593. doi: 10.1046/j.1365-2362.1999.00510.x
Khan, Faisel, Litchfield, Stuart J., McLaren, Margaret, Veale, Douglas J., Littleford, Roberta C. and Belch, Jill J. F. (1997). Oral L-arginine supplementation and cutaneous vascular responses in patients with primary Raynaud's phenomenon. Arthritis and Rheumatism, 40 (2), 352-357. doi: 10.1002/art.1780400220
Littleford, R. C., Khan, F., Hindley, M. O., Ho, M. and Belch, J. J.F. (1997). Microvascular abnormalities in patients with vibration white finger. QJM - Monthly Journal of the Association of Physicians, 90 (8), 525-529. doi: 10.1093/qjmed/90.8.525
Khan, Faisel, Davidson, Neil C., Littleford, Roberta C., Litchfield, Stuart J., Struthers, Allan D. and Belch, Jill J.F. (1997). Cutaneous vascular responses to acetylcholine are mediated by a prostanoid-dependent mechanism in man. Vascular Medicine, 2 (2), 82-86. doi: 10.1177/1358863X9700200202
Belch, Jill J., Greene, Steve A., Littleford, Roberta, Jennings, Paul E. and Khan, Faisel (1996). Impaired skin blood flow response to heat in children with insulin-dependent diabetes. International Journal of Angiology, 5 (4), 189-191. doi: 10.1007/BF02044255
Conference Papers
Pourzinal, D., Bakker, A., Byrne, G. J., McMahon, K., O'Sullivan, J., Adam, R., Copland, D., Yang, J. H. J., Au, T., Littleford, R., Chatfield, M., Pontone, G., Mari, Z. and Dissanayaka, N. (2020). Therapy to Reduce dementia risk In Parkinson’s disease (TRIP): proof-of-concept protocol. UQ Faculty of Medicine Higher Degree by Research Student Symposium, Brisbane, QLD, Australia, 23-27 November 2020.
Pourzinal, D., Bakker, A., Byrne, G. J., McMahon, K., O'Sullivan, J., Adam, R., Copland, D., Yang, J. H. J., Au, T., Littleford, R., Chatfield, M., Pontone, G., Mari, G. and Dissanayaka, N. (2020). Therapy to reduce dementia risk in Parkinson’s disease (TRIP): proof-of-concept protocol. Herston Health Precinct Symposium 2020, Brisbane, QLD, Australia, 7-11 December 2020.
Pourzinal, D., Bakker, A., Byrne, G., McMahon, K.L., O'Sullivan, J.D., Adam, R., Lehn, A., Copland, D., Yang, J.H., Au, T., Littleford, R., Chatfield, M., Pontone, G., Mari, Z. and Dissanayaka, N.N.W. (2020). Therapy to Reduce dementia risk In Parkinson’s disease (TRIP): Proof-of-concept protocol.. Macquarie University BioNetwork 3rd Annual Research Symposium on Dementia, Online, 14-15 September 2020.