My research spans areas of molecular biology of membrane transport and regulation of ion channels in kidney and brain. I have made progress in understanding how renal ion transporters/channels function and defining the mechanisms of their regulation. My current focus is in homeostasis of neurotransmitter (such as glutamate) in normal and pathological brain. I am interested in the roles of glial and neuronal transporters in determining outcomes at the cellular level and whole brain level after hypoxic insults. I have been active in cloning new glutamate transporter splice variants and determining how expression of such variants changes in various disease states.