Dr Patty Hernandez Mitre

Postdoctoral Research Fellow

UQ Centre for Clinical Research

p.mitre@uq.edu.au

Researcher biography

Dr Patty Hernández Mitre is a Postdoctoral Research Fellow in the Antimicrobial Optimisation Group and team member of the CRE-RESPOND (Centre of Research Excellence - REduce the burden of antimicrobial reSistance through oPtimal persONalised Dosing) at the University of Queensland Centre for Clinical Research (UQCCR) in Brisbane, Queensland, Australia.

Patty performs non-compartmental pharmacokinetic analysis of Phase I investigational drugs using Phoenix WinNonlin, as well as population pharmacokinetic modelling for clinical collaborators of a variety of drugs including antiepileptics, antimicrobials and antifungals, using NONMEM and Pmetrics.

She currently leads the data analysis of the Screening Anti-Fungal Exposure in Intensive Care Units (SAFE-ICU) study, a multi-national study across 12 countries that aims to develop optimised antibiotic dosing guidelines for ICU patients with life-threatening infections that account for patient characteristics.

Publications

Journal Articles (8)

Conference Paper (1)

Research Report (1)

Journal Articles

Novy, Emmanuel, Liu, Xin, Hernandez-Mitre, Maria Patricia, Belveyre, Thibaut, Scala-Bertola, Julien, A Roberts, Jason and L Parker, Suzanne (2024). Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: A prospective monocentric study. Anaesthesia Critical Care & Pain Medicine 101376, 101376. doi: 10.1016/j.accpm.2024.101376

Hernández-Mitre, María Patricia, Wallis, Steven C., Morgan, Elizabeth E., Dudley, Michael N., Loutit, Jeffery S., Griffith, David C. and Roberts, Jason A. (2023). A phase I, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the pharmacokinetics, safety, and tolerability of oral ceftibuten in healthy adult subjects. Antimicrobial Agents and Chemotherapy, 68 (1) e0109923, 1-12. doi: 10.1128/aac.01099-23

Hernández-Mitre, María Patricia, Won, Hayoung, Wallis, Steven C., Parker, Suzanne L. and Roberts, Jason A. (2023). Stability of nafamostat in intravenous infusion solutions, human whole blood and extracted plasma: implications for clinical effectiveness studies. Bioanalysis, 15 (12), 673-681. doi: 10.4155/bio-2023-0040

Roberts, Jason A., Sime, Fekade, Lipman, Jeffrey, Hernández-Mitre, Maria Patricia, Baptista, João Pedro, Brüggemann, Roger J., Darvall, Jai, De Waele, Jan J., Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Wong, Wai Tat, Zeitlinger, Markus and Roger, Claire (2023). A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU study. Critical Care and Resuscitation, 25 (1), 1-5. doi: 10.1016/j.ccrj.2023.04.002

Hernández-Mitre, María Patricia, Tong, Steven Y. C., Denholm, Justin T., Dore, Gregory J., Bowen, Asha C., Lewin, Sharon R., Venkatesh, Balasubramanian, Hills, Thomas E., McQuilten, Zoe, Paterson, David L., Morpeth, Susan C. and Roberts, Jason A. (2022). Nafamostat mesylate for treatment of COVID-19 in hospitalised patients: a structured, narrative review. Clinical Pharmacokinetics, 61 (10), 1331-1343. doi: 10.1007/s40262-022-01170-x

Hernandez-Mitre, Maria P., Medellin-Garibay, Susanna E., Rodríguez-Leyva, Ildefonso, Rodríguez-Pinal, Cristian J., Zarazúa, Sergio, Jung-Cook, Helgi H., Parker, Suzanne L., Romano-Moreno, Silvia and del C. Milán-Segovia, Rosa (2020). Determination of Levetiracetam in Plasma by a Modified HPLC-UV Method and Its Pharmacokinetic Application. Mathews Journal of Pharmaceutical Science, 4 (1). doi: 10.30654/mjps.10004

Hernández-Mitre, María Patricia, Medellín-Garibay, Susanna Edith, Rodríguez-Leyva, Ildefonso, Rodríguez-Pinal, Cristian Jazmín, Zarazúa, Sergio, Jung-Cook, Helgi Helene, Roberts, Jason A., Romano-Moreno, Silvia and Milán-Segovia, Rosa del Carmen (2020). Population pharmacokinetics and dosing recommendations of levetiracetam in adult and elderly patients with epilepsy. Journal of Pharmaceutical Sciences, 109 (6), 2070-2078. doi: 10.1016/j.xphs.2020.02.018

Hernandez-Mitre, Maria Patricia, Medellin-Garibay, Susanna Edith, Rodriguez-Leyva, Ildefonso, Castillo-Ibarra, Herlinda, Rodríguez-Pinal, Cristian Jasmin, Zarazua-Guzman, Sergio, Jung-Cook, Helgi Helene, Romano-Moreno, Silvia and del Carlmen Milan-Segovia, Rosa (2020). Population Pharmacokinetics Of Levetiracetam In Mexican Adult Patients With Epilepsy (4643). Neurology, 94 (15_supplement). doi: 10.1212/wnl.94.15_supplement.4643

Conference Paper

Zamri, Puteri Juanita, Abdul-Aziz, Mohd-Hafiz, Hernandez-Mitre, Maria Patricia, Hasan, Mohd Shahnaz, Shariff, Izyani Md, Sulaiman, Helmi, Wallis, Steve, Sumi, Chandra Datta, Sime, Fekade Bruck and Roberts, Jason A (2022). Pharmacokinetics of polymyxin B and the pharmacokinetic/pharmacodynamic target attainment in hospitalised adult patients with multidrug-resistant gram-negative infections. 32nd International Congress of Antimicrobial Chemotherapy (ICC), Perth, Australia, 27-30 November 2022. Amsterdam, Netherlands: Elsevier . doi: 10.1016/s2213-7165(22)00339-3

Research Report

Hernández-Mitre, María Patricia, UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia, Morpeth, Susan C., Venkatesh, Balasubramanian, Hills, Thomas E., Davis, Joshua, Mahar, Robert K., McPhee, Grace, Jones, Mark, Totterdell, James, Tong, Steven Y. C. and Roberts, Jason A. (2023). TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of nafamostat and camostat mesylate randomised clinical trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols. doi: 10.37766/inplasy2023.2.0120