Research interest

To study breast cancer metastases using preclinical models 

My research objectives are aimed towards understanding and developing therapeutic interventions for breast cancer and metastases. My program of work comprises of two main interests; brain metastasis and role of neo-antigens in triple-negative breast cancer. I am interested in understanding the influence of the  unique tumour/tissue microenvironment (TME) in metastases, which is known to play a role in this process. To achieve this I have established brain metastatic tumours from the breast using intra-cranial, intra-cardiac preclinical models along with molecular biology, genomic and proteomic tools. In triple-negative breast cancer I am determining biomarkers in the neoadjuvant setting especially neo-antigens. I am exploring the expression of neo-antigens using immunohistochemical techniques in patients with neoadjuvant chemotherapy.  I use a variety of statistical algorithms and clinical data analysis tools to achieve this.

Researcher biography

I am a molecular biologist with an honours degree in Medical Biotechnology (The University of Abertay Dundee, Scotland) and a PhD in Physiology and Medicine from the University of Otago (Dunedin, New Zealand) specialising in the development and use of preclinical disease models. I moved to Australia to pursue my passion for cancer research and employ my expertise of preclinical disease modelling in breast cancer brain metastases in Professor Lakhani's laboratory.