Dr Xin Liu
Pharmacokinetic Analyst & Pharmacokinetic Analyst
UQ Centre for Clinical Research
Honorary Research Fellow & Research Fellow
Frazer Institute
+61 7 344 38031
Researcher biography
Dr Liu is a research fellow with more than 15 years of experience in the field of pharmacometrics. She specialises in population pharmacokinetic modelling and provides popPK analysis and dosing simulation support for various projects in Centre of Research Excellence RESPOND
Book Chapters
Holmes, Amy, Thorling, Camilla, Liu, Xin, Liang, Xiaowen, Wang, Haolu, Breunig, Hans G., König, Karsten, Studier, Hauke and Roberts, Michael S. (2018). Revealing interaction of dyes and nanomaterials by multiphoton imaging. Multiphoton microscopy and fluorescence lifetime imaging: applications in biology and medicine. (pp. 345-368) edited by Karsten König. Berlin, Germany: Walter de Gruyter. doi: 10.1515/9783110429985-020
Liu, X., Wang, H., Liang, X. and Roberts, M. S. (2017). Hepatic metabolism in liver health and disease. Liver Pathophysiology: Therapies and Antioxidants. (pp. 391-400) edited by Pablo Muriel. Cambridge, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-804274-8.00030-8
Liang, Xiaowen, Wang, Haolu, Liu, Xin, Grice, Jeffrey, Xu, Zhi Ping and Roberts, Michael S. (2017). Related topic: Safety evaluation of nanomaterials. Skin permeation and disposition of therapeutic and cosmeceutical compounds. (pp. 313-322) edited by Kenji Sugibayashi. Tokyo, Japan: Springer Japan. doi: 10.1007/978-4-431-56526-0_28
Kruger, P., Liu, X. and Roberts, M. S. (2009). Optimizing drug dosing in the ICU. Optimizing Drug Dosing in the ICU. (pp. 859-869) edited by Vincent, JL. Berlin, Germany: Springer. doi: 10.1007/978-3-540-92276-6
Journal Articles
Novy, Emmanuel, Liu, Xin, Hernandez-Mitre, Maria Patricia, Belveyre, Thibaut, Scala-Bertola, Julien, Roberts, Jason A. and Parker, Suzanne L. (2024). Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: a prospective monocentric study. Anaesthesia Critical Care and Pain Medicine, 43 (3) 101376, 1-8. doi: 10.1016/j.accpm.2024.101376
Ngougni Pokem, Perrin, Liu, Xin, Parker, Suzanne L., Verroken, Alexia, Collienne, Christine, Finet, Patrice, Wijnant, Gert-Jan, Laterre, Pierre-François, Roberts, Jason A., Van Bambeke, Françoise and Wittebole, Xavier (2024). Population pharmacokinetics and dosing simulations of total and unbound temocillin in the plasma and CSF of neurocritically ill patients with external ventricular drain-related cerebral ventriculitis. Journal of Antimicrobial Chemotherapy, 79 (2), 429-442. doi: 10.1093/jac/dkad398
Zou, Da, Wu, Zeming, Yi, Xin, Hui, Yue, Yang, Guangze, Liu, Yun, Tengjisi,, Wang, Haofei, Brooks, Anastasia, Wang, Haolu, Liu, Xin, Xu, Zhi Ping, Roberts, Michael S., Gao, Huajian and Zhao, Chun-Xia (2022). Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions. Proceedings of the National Academy of Sciences, 120 (1) e2214757120, e2214757120. doi: 10.1073/pnas.2214757120
Liu, Xin, Cheruvu, Hanumanth S., Anissimov, Yuri G., van der Hoek, John, Tsakalozou, Eleftheria, Ni, Zhanglin, Ghosh, Priyanka, Grice, Jeffrey E. and Roberts, Michael S. (2022). Percutaneous absorption of steroids from finite doses: predicting urinary excretion from in vitro skin permeation testing. International Journal of Pharmaceutics, 625 122095, 1-16. doi: 10.1016/j.ijpharm.2022.122095
Liu, Xin, Wang, Haolu, Liu, Xinyao, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2022). Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis. Pharmacology and Therapeutics, 237 108163, 1-13. doi: 10.1016/j.pharmthera.2022.108163
Cheruvu, Hanumanth Srikanth, Liu, Xin, Grice, Jeffrey E and Roberts, Michael S. (2022). An updated database of human maximum skin fluxes and epidermal permeability coefficients for drugs, xenobiotics, and other solutes applied as aqueous solutions. Data in Brief, 42 108242, 1-9. doi: 10.1016/j.dib.2022.108242
Zou, Da, Wang, Haolu, Liu, Xin, Xu, Zhi Ping, Roberts, Michael S. and Zhao, Chun-Xia (2021). Artificial cells for the treatment of liver diseases. Acta Biomaterialia, 130, 98-114. doi: 10.1016/j.actbio.2021.06.012
Liu, Xin, Anissimov, Yuri G., Grice, Jeffrey E., Cheruvu, Hanumanth Srikanth, Ghosh, Priyanka, Raney, Sam G., Maibach, Howard and Roberts, Michael S. (2021). Relating transdermal delivery plasma pharmacokinetics with in vitro permeation test (IVPT) findings using diffusion and compartment-in-series models. Journal of Controlled Release, 334, 37-51. doi: 10.1016/j.jconrel.2021.04.010
Liu, Xin, Yousef, Shereen, Anissimov, Yuri G., van der Hoek, John, Tsakalozou, Eleftheria, Ni, Zhanglin, Grice, Jeffrey E. and Roberts, Michael S. (2020). Diffusion modelling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose. European Journal of Pharmaceutics and Biopharmaceutics, 149, 30-44. doi: 10.1016/j.ejpb.2020.01.018
Wang, Haolu, Burke, Leslie J., Patel, Jatin, Tse, Brian W.C., Bridle, Kim R., Cogger, Victoria C., Li, Xinxing, Liu, Xin, Yang, Haotian, Crawford, Darrell H. G., Roberts, Michael S., Gao, Wenchao and Liang, Xiaowen (2020). Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics, 10 (15), 6715-6727. doi: 10.7150/thno.44900
Cheruvu, Hanumanth Srikanth, Liu, Xin, Grice, Jeffrey E. and Roberts, Michael S. (2020). Modeling percutaneous absorption for successful drug discovery and development. Expert Opinion on Drug Discovery, 15 (10), 1-18. doi: 10.1080/17460441.2020.1781085
Wang, Haolu, Yang, Haotian, Xu, Zhi Ping, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Anionic long-circulating quantum dots for long-term intravital vascular imaging. Pharmaceutics, 10 (4) 244, 244. doi: 10.3390/pharmaceutics10040244
Wu, Chao, Kan, Hongwei, Hu, Min, Liu, Xin, Boye, Alex, Jiang, Yufeng, Wu, Jiajun, Wang, Jiyu, Yang, Xiaochuan and Yang, Yan (2018). Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocarcinogenesis via modulating TGF-β/tβr and imp7/8. Experimental and Therapeutic Medicine, 16 (2), 1052-1060. doi: 10.3892/etm.2018.6292
Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A., Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics, 8 (5), 1227-1242. doi: 10.7150/thno.22872
Jin, Wang, Liang, Xiaowen, Brooks, Anastasia, Futrega, Kathryn, Liu, Xin, Doran, Michael R., Simpson, Matthew J., Roberts, Michael S. and Wang, Haolu (2018). Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice. PeerJ, 2018 (12) e6072, e6072. doi: 10.7717/peerj.6072
Brooks, Anastasia, Futrega, Kathryn, Liang, Xiaowen, Hu, Xiaoling, Liu, Xin, Crawford, Darrell H. G., Doran, Michael R., Roberts, Michael S. and Wang, Haolu (2017). Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells. Stem Cells Translational Medicine, 7 (1), 78-86. doi: 10.1002/sctm.17-0209
Wang, Haolu, Thorling, Camilla A., Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells. Current Protocols in Stem Cell Biology, 43 (1), 1-17. doi: 10.1002/cpsc.39
Liu, Xin, Liang, Xiaowen, Wang, Haolu, Roberts, Darren M. and Roberts, Michael S. (2017). Multiphoton imaging for assessing renal disposition in acute kidney injury. SPIE Biophotonics Australasia, 10013. doi: 10.1117/12.2242964
Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 (1) 45374. doi: 10.1038/srep45374
Yousef, Shereen, Liu, Xin, Mostafa, Ahmed, Mohammed, Yousuf, Grice, Jeffrey E., Anissimov, Yuri G., Sakran, Wedad and Roberts, Michael S. (2016). Estimating maximal in vitro skin permeation flux from studies using non-sink receptor phase conditions. Pharmaceutical Research, 33 (9), 2180-2194. doi: 10.1007/s11095-016-1955-8
Wang, Haolu, Liang, Xiaowen, Gravot, Germain, Thorling, Camilla A., Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2016). Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy. Journal of Biophotonics, 10 (1), 46-60. doi: 10.1002/jbio.201600083
Wang, Haolu, Liang, Xiaowen, Xu, Zhi Ping, Crawford, Darrell H. G, Liu, Xin and Roberts, Michael S. (2016). A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells. Scientific Reports, 6 (1) 22293, e22293.1-e22293.12. doi: 10.1038/srep22293
Liang, Xiaowen, Wang, Haolu, Grice, Jeffrey E., Li, Li, Liu, Xin, Xu, Zhi Ping and Roberts, Michael S. (2016). Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles. Nano Letters, 16 (2), 939-945. doi: 10.1021/acs.nanolett.5b03854
Liang, Xiaowen, Wang, Haolu, Zhu, Yian, Zhang, Run, Cogger, Victoria C., Liu, Xin, Xu, Zhi Ping, Grice, Jeffrey E. and Roberts, Michael S. (2016). Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney. Acs Nano, 10 (1), 387-395. doi: 10.1021/acsnano.5b05066
Jin, Yue, Wang, Haolu, Ma, Xiaowei, Liang, Xiaowen, Liu, Xin and Wang, Yu (2015). Clinicopathological characteristics of gynecological cancer associated with hypoxia-inducible factor 1α expression: a meta-analysis including 6,612 subjects. PLoS ONE, 10 (5) e0127229, e0127229. doi: 10.1371/journal.pone.0127229
Mahmood, Adnan H., Liu, Xin, Grice, Jeffrey E., Medley, Gregory A. and Roberts, Michael S. (2015). Using deconvolution to understand the mechanism for variable plasma concentration-time profiles after intramuscular injection. International Journal of Pharmaceutics, 481 (1-2), 71-78. doi: 10.1016/j.ijpharm.2015.01.046
Roberts, Darren M, Liu, Xin, Roberts, Jason A, Nair, Priya, Cole, Louise, Roberts, Michael S, Lipman, Jeffrey, Bellomo, Rinaldo and RENAL Replacement Therapy Study Investigators (2015). A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics. Critical Care, 19 (84) 84, 84. doi: 10.1186/s13054-015-0818-8
Wang, Haolu, Liang, Xiaowen, Mohammed, Yousuf H., Thomas, James A., Bridle, Kim R., Thorling, Camilla A., Grice, Jeffrey E., Xu, Zhi Ping, Liu, Xin, Crawford, Darrell H. G. and Roberts, Michael S. (2015). Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging. Biomedical Optics Express, 6 (3), 780-792. doi: 10.1364/BOE.6.000780
Wang, Haolu, Thorling, Camilla A., Liang, Xiaowen, Bridle, Kim R., Grice, Jeffrey E., Zhu, Yian, Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2015). Diagnostic imaging and therapeutic application of nanoparticles targeting the liver. Journal of Materials Chemistry B, 3 (6), 939-958. doi: 10.1039/C4TB01611D
Thorling C.A., Jin L., Weiss M., Crawford D., Liu X., Burczynski F.J., Liu D., Wang H. and Roberts M.S. (2015). Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition. Drug Metabolism and Disposition, 43 (1), 154-162. doi: 10.1124/dmd.114.060848
Liu, Xin, Kruger, Peter, Maibach, Howard, Colditz, Paul B. and Roberts, Michael S. (2014). Using skin for drug delivery and diagnosis in the critically ill. Advanced Drug Delivery Reviews, 77, 40-49. doi: 10.1016/j.addr.2014.10.004
Wunnapuk, Klintean, Mohammed, Fahim, Gawarammana, Indika, Liu, Xin, Verbeeck, Roger K., Buckley, Nicholas A., Roberts, Michael S. and Musuamba, Flora T. (2014). Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach. British Journal of Clinical Pharmacology, 78 (4), 855-866. doi: 10.1111/bcp.12389
Thorling, Camilla A., Crawford, Darrell, Burczynski, Frank J., Liu, Xin, Liau, Ian and Roberts, Michael S. (2014). Multiphoton microscopy in defining liver function. Journal of Biomedical Optics, 19 (9) 090901, 90901-090901. doi: 10.1117/1.JBO.19.9.090901
Thorling, Camilla A., Roberts, Michael S., Liu, Xin, Fletcher, Linda M., Crawford, Darrell and Burczynski, Frank J. (2014). Effects of long-term hepatic ischemia-reperfusion injury on the function of P-glycoprotein in vivo in rats. Journal of Pharmacy and Pharmaceutical Sciences, 17 (1), 121-135. doi: 10.18433/J33C7B
Wunnapuk, Klintean, Liu, Xin, Gobe, Glenda C., Endre, Zoltan H., Peake, Philip W., Grice, Jeffrey E., Roberts, Michael S. and Buckley, Nicholas A. (2014). Kidney biomarkers in MCPA-induced acute kidney injury in rats: reduced clearance enhances early biomarker performance. Toxicology Letters, 225 (3), 467-478. doi: 10.1016/j.toxlet.2014.01.018
Wunnapuk, Klintean, Gobe, Glenda, Endre, Zoltan, Peake, Philip, Grice, Jeffrey E., Roberts, Michael S., Buckley, Nicholas A. and Liu, Xin (2014). Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers. Toxicology Letters, 225 (1), 192-200. doi: 10.1016/j.toxlet.2013.12.009
Rui, Wenjuan, Xie, Lei, Liu, Xin, He, Shufang, Wu, Chao, Zhang, Xiaoxiang, Zhang, Linjie and Yang, Yan (2014). Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription. Journal of Ethnopharmacology, 151 (1), 198-209. doi: 10.1016/j.jep.2013.10.022
Liang X., Grice J.E., Zhu Y., Liu D., Sanchez W.Y., Li Z., Crawford D.H.G., Le Couteur D.G., Cogger V.C., Liu X., Xu Z.P. and Roberts M.S. (2014). Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells. Small, 11 (14), 1711-1720. doi: 10.1002/smll.201402698
Wunnapuk, Klintean, Liu, Xin, Peake, Philip, Gobe, Glenda, Endre, Zoltan, Grice, Jeffrey E., Roberts, Michael S. and Buckley, Nicholas A. (2013). Renal biomarkers predict nephrotoxicity after paraquat. Toxicology Letters, 222 (3), 280-288. doi: 10.1016/j.toxlet.2013.08.003
Liang, Xiao Wen, Xu, Zhi Ping, Grice, Jeffrey, Zvyagin, Andrei V., Roberts, Michael S. and Liu, Xin (2013). Penetration of Nanoparticles into Human Skin. Current Pharmaceutical Design, 19 (35), 6353-6366. doi: 10.2174/1381612811319350011
Weiss, Michael, Liu, Xin, Thorling, Camilla A. and Roberts, Michael S. (2013). Functional characterization of hepatic transporters using intravital microscopy. European Journal of Pharmaceutical Sciences, 49 (5), 845-849. doi: 10.1016/j.ejps.2013.06.006
Shao, Feng, Zhu, Tian, Tang, Feng and Liu, Xin (2013). Simultaneous quantification of tafetinib (SIM010603), a novel potent inhibitor of receptor tyrosine kinase, and its major metabolite in dog plasma by HPLC-ESI/MS/MS and its application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis, 81-82, 50-55. doi: 10.1016/j.jpba.2013.02.041
Liu, Xin, Jin, Lu, Upham, John W. and Roberts, Michael S. (2013). The development of models for the evaluation of pulmonary drug disposition. Expert Opinion On Drug Metabolism & Toxicology, 9 (4), 487-505. doi: 10.1517/17425255.2013.754009
Thorling, Camilla A., Liu, Xin, Burczynski, Frank J., Fletcher, Linda M., Roberts, Michael S. and Sanchez, Washington Y. (2013). Intravital multiphoton microscopy can model uptake and excretion of fluorescein in hepatic ischemia-reperfusion injury. Journal of Biomedical Optics, 18 (10) 101306, 1-12. doi: 10.1117/1.JBO.18.10.101306
Roberts, Darren M., Roberts, Jason A., Roberts, Michael S., Liu, Xin, Nair, Priya, Cole, Louise, Lipman, Jeffrey, Bellomo, Rinaldo and on behalf of the RENAL Replacement Therapy Study Investigators (2012). Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study. Critical Care Medicine, 40 (5), 1523-1528. doi: 10.1097/CCM.0b013e318241e553
Liu, Xin, Kruger, Peter S., Weiss, Michael and Roberts, Michael S. (2012). The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis. British Journal of Clinical Pharmacology, 73 (5), 741-749. doi: 10.1111/j.1365-2125.2011.04149.x
Mahmood, Adnan H., Medley, Gregory A., Grice, Jeffrey E., Liu, Xin and Roberts, Michael S. (2012). Determination of trovafloxacin and marbofloxacin in sheep plasma samples by HPLC using UV detection. Journal of Pharmaceutical and Biomedical Analysis, 62, 220-223. doi: 10.1016/j.jpba.2012.01.007
He, S., Yang, Y., Liu, X., Huang, W., Zhang, X., Yang, S. and Zhang, X. (2012). Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-beta/Smad pathway. British Journal of Dermatology, 166 (3), 564-574. doi: 10.1111/j.1365-2133.2011.10674.x
Jayaraman, Ramesh, Reddy, Venkatesh P., Pasha, Mohammed Khalid, Wang, Haishan, Sangthongpitag, Kanda, Yeo, Pauline, Hu, Chang Yong, Wu, Xiaofeng, Xin, Liu, Goh, Evelyn, New, Lee Sun and Ethirajulu, Kantharaj (2011). Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metabolism and Disposition, 39 (12), 2219-2232. doi: 10.1124/dmd.111.041558
Liu, Xin, Grice, Jeff E., Lademann, Juergen, Otberg, Nina, Trauer, Sindy, Patzelt, Alexa and Roberts, Michael S. (2011). Hair follicles contribute significantly to penetration through human skin only at times soon after application as a solvent deposited solid in man. British Journal of Clinical Pharmacology, 72 (5), 768-774. doi: 10.1111/j.1365-2125.2011.04022.x
Thorling, Camilla A., Liu, Xin, Burczynski, Frank J., Fletcher, Linda M., Gobe, Glenda C. and Roberts, Michael S. (2011). Multiphoton microscopy can visualize zonal damage and decreased cellular metabolic activity in hepatic ischemia-reperfusion injury in rats. Journal of Biomedical Optics, 16 (11) 116011, 116011-1160118. doi: 10.1117/1.3647597
Wunnapuk, Klintean, Medley, Gregory A., Liu, Xin, Grice, Jeffrey E., Jayasinghe, Sudheera, Gawarammana, Indika, Buckley, Nicholas A. and Roberts, Michael S. (2011). Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of paraquat in plasma and urine: Application to experimental and clinical toxicological studies. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 879 (28), 3047-3052. doi: 10.1016/j.jchromb.2011.09.008
Mostafa, Ahmed, Medley, Gregory, Roberts, Darren M., Mohamed, Mosaad Sayed, Elshanawani, Abdalla A., Roberts, Michael S. and Liu, Xin (2011). Simultaneous quantification of carbamate insecticides in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 879 (23), 2234-2238. doi: 10.1016/j.jchromb.2011.06.006
Thorling, Camilla A., Dancik, Yuri, Hupple, Clinton W., Medley, Gregory, Liu, Xin, Zvyagin, Andrei V., Robertson, Tom A., Burczynski, Frank J. and Roberts, Michael S. (2011). Multiphoton microscopy and fluorescence lifetime imaging provide a novel method in studying drug distribution and metabolism in the rat liver in vivo. Journal of Biomedical Optics, 16 (8) 086013, 086013-1-086013-7. doi: 10.1117/1.3614473
Wang, Haishan, Yu, Niefang, Chen, Dizhong, Lee, Ken Chi Lik, Lye, Pek Ling, Chang, Joyce Wei Wei, Deng, Weiping, Ng, Melvin Chi Yeh, Lu, Ting, Khoo, Mui Ling, Poulsen, Anders, Sangthongpitag, Kanda, Wu, Xiaofeng, Hu, Changyong, Goh, Kee Chuan, Wang, Xukun, Fang, Lijuan, Goh, Kay Lin, Khng, Hwee Hoon, Goh, Siok Kun, Yeo, Pauline, Liu, Xin, Bonday, Zahid, Wood, Jeanette M., Dymock, Brian W., Kantharaj, Kanthara and Sun, Eric T. (2011). Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. Journal of Medicinal Chemistry, 54 (13), 4694-4720. doi: 10.1021/jm2003552
Liu, Xin, Kruger, Peter S. and Roberts, Michael S. (2011). How to measure pharmacokinetics in critically ill patients?. Current Pharmaceutical Biotechnology, 12 (12), 2037-2043. doi: 10.2174/138920111798808239
Roberts, Michael S., Liu, Xin, Zou, Yuhong, Siebert, Gerhard A., Chang, Ping, Whitehouse, Michael W., Fletcher, Linda and Crawford, Darrell H. G. (2011). Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholate. American Journal of Physiology-gastrointestinal And Liver Physiology, 300 (1), G130-G136. doi: 10.1152/ajpgi.00162.2010
Liu, Xin, Zou, Yuhong, Khlentzos, Alexander M., Yang, Yan, Nikolovski, Julijana, Weiss, Michael and Roberts, Michael S. (2010). Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing. Clinical and Experimental Pharmacology and Physiology, 37 (10), 1028-1033. doi: 10.1111/j.1440-1681.2010.05434.x
He, S., Liu, X., Yang, Y., Huang, W., Xu, S., Yang, S., Zhang, X. and Roberts, M. S. (2010). Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts. British Journal of Dermatology, 162 (3), 538-546. doi: 10.1111/j.1365-2133.2009.09511.x
Liu, Xin, Yang, Yan, Zhang, Xiaoxiang, Xu, Shengxin, He, Shufang, Huang, Weijuan and Roberts, Michael S. (2010). Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2. Journal of Gastroenterology and Hepatology, 25 (2), 420-426. doi: 10.1111/j.1440-1746.2009.05981.x
Zou, Yu-Hong, Liu, Xin, Khlentzos, Alexander M., Asadian, Peyman, Li, Peng, Thorling, Camilla A., Robertson, Thomas A., Fletcher, Linda M., Crawford, Darrell H. G. and Roberts, Michael S. (2010). Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model. Drug Metabolism and Pharmacokinetics, 25 (5), 442-449. doi: 10.2133/dmpk.DMPK-10-RG-031
Liu, X., Wang, J. Y., Khlentzos, A. M., Fontaine, F., Nikolovski, J., Goh, L.- A. and Roberts, M. S. (2009). Influence of perfusate composition on drug disposition in the in-situ perfused rat lung. International Journal of Pharmaceutics, 382 (1-2), 192-197. doi: 10.1016/j.ijpharm.2009.08.028
Liu, Xin, Chan, S. Y. and Ho, P. C. (2008). Comparison of the in vitro and in vivo effects of retinoids either alone or in combination with cisplatin and 5-fluorouracil on tumor development and metastasis of melanoma.. Cancer Chemotherapy and Pharmacology, 63 (1), 167-174. doi: 10.1007/s00280-008-0763-1
Li, P., Wang, G-J., Li, J., Liu, X., Khlentzos, A. and Roberts, M. S. (2008). The prediction of the hepatic clearance of Tanshinone IIA in a rat liver subcellular fractions: accuracy improvement. Current Drug Metabolism, 9 (1), 39-45. doi: 10.2174/138920008783331103
Venkadesh, Pilla Reddy, Goh, Evelyn, Zeng, Peizi, New, Lee Sun, Liu, Xin, Pasha, Mohammed Khalid, Sangthongpitag, Kanda, Yeo, Pauline and Kantharaj, Ethirajulu (2007). In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species. Biological and Pharmaceutical Bulletin, 30 (5), 1021-1024. doi: 10.1248/bpb.30.1021
Yeo, Pauline, Xin, Liu, Goh, Evelyn, New, Lee Sun, Zeng, Peizi, Wu, Xiaofeng, Venkatesh, P. and Kantharaj, Ethirajulu (2007). Development and validation of high-performance liquid chromatography-tandem mass spectrometry assay for 6-(3-benzoyl-ureido)-hexanoic acid hydroxyamide, a novel HDAC inhibitor, in mouse plasma for pharmacokinetic studies. Biomedical Chromatography, 21 (2), 184-189. doi: 10.1002/bmc.734
Yap, K. L., Liu, X., Thenmozhiyal, J. C. and Ho, P. C. (2005). Characterization of the 13-cis-retinoic acid/cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysis. European Journal of Pharmaceutical Sciences, 25 (1), 49-56. doi: 10.1016/j.ejps.2005.01.021
Liu, X., Lin, H. S., Chan, S. Y. and Ho, P. C. (2004). Biopharmaceutics of beta-cyclodextrin derivative-based formulations of acitretin in Sprague-Dawley rats. Journal of Pharmaceutical Sciences, 93 (4), 805-815. doi: 10.1002/jps.10578
Liu, X., Lin, H. S., Thenmozhiyal, J. C., Chan, S. Y. and Ho, P. C. (2003). Inclusion of acitretin into cyclodextrins: Phase solubility, photostability, and physicochemical characterization. Journal of Pharmaceutical Sciences, 92 (12), 2449-2457. doi: 10.1002/jps.10495
Conference Papers
Roberts, Michael S., Barkauskas, Deborah, Wang, Haolu, Liu, Xin, Studier, Hauke, Pastore, Michael, Zhang, Run, Holmes, Amy, Grice, Jeffrey E., Xu, Zhiping, Mohammed, Yousuf S. and Liang, Xiaowen (2020). Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes. Multiphoton Microscopy in the Biomedical Sciences, San Francisco, CA United States, 2-4 February 2020. Bellingham, WA United States: SPIE. doi: 10.1117/12.2546058
Liang, X., Wang, H., Liu, X., Touraud, M., Chouane, J. B., Tse, B. and Roberts, M. S. (2017). Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, , Gold Coast, Queensland, Australia, 20–22 Aug 2017. Richmond, VIC Australia: Wiley.
Wang, H., Liang, X., Weijs, L., Brooks, A., Liu, X., Roberts, M. S. and Crawford, D. H. G. (2017). Characterizing and predicting the in vivo kinetics of mesenchymal stem cells and their secretome for the treatment of liver cirrhosis. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, Queensland, 20–22 Aug 2017. Hoboken, NJ United States: Wiley.
Thorling (Thompson), Camilla, Wang, Haolu, Liu, Xin, Liang, Xiaowen, Crawford, Darrell H. G. and Roberts, Michael S. (2017). Non-invasive assessment of the liver using imaging. SPIE BioPhotonics Australasia Conference, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242883
Liang, Xiaowen, Wang, Haolu, Liu, Xin and Roberts, Michael (2017). Quantitative optical imaging of paracetamol-induced metabolism changes in the liver. SPIE BioPhotonics Australasia, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242962
Wang, Haolu, Jayachandran, Aparna, Gravot, Germain, Liang, Xiaowen, Thorling, Camilla A., Zhang, Run, Liu, Xin and Roberts, Michael S. (2017). In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe. SPIE BioPhotonics Australasia Conference, Adelaide,SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: S P I E - International Society for Optical Engineering. doi: 10.1117/12.2242978
Wang, H., Liang, X., Endo-Munoz, L., Weijs, L., Liu, X., Crawford, D. and Roberts, M. (2015). A blood-flow limited physiologically based kinetic model to characterize and predict the biological fate of mesenchymal stem cells in vivo. Gastro 2015 GESA‐AGW And WGO International Congress, Gastroenterological Society Of Australia Australian Gastroenterology Week 2015 - World Congress Of Gastroenterology, , Brisbane, Queensland, Australia, 28 September‐2 October 2015. Richmond, VIC Australia: Wiley.
Liang, X., Wang, H., Zhu, Y., Grice, J., Liu, X., Xu, Z. and Roberts, M. (2015). Early diagnosis of hepatocellular carcinoma by in vivo imaging. European Cancer Congress, Vienna, Austria, 2015. Oxford, United Kingdom: Elsevier. doi: 10.1016/S0959-8049(16)30378-1
Wang, H., Liang, X., Thorling, C., Xu, Z. P., Crawford, D., Liu, X. and Roberts, M. (2015). A physiologically based kinetic model to characterize and predict the biological fate of circulating tumor cells in vivo. European Cancer Congress, Vienna, Austria, 2015. Hoboken, NJ United States: Wiley. doi: 10.1016/S0959-8049(15)30013-7
Thorling, Camilla A., Liu, Xin, Burczynski, Frank J., Fletcher, Linda M. and Roberts, Michael S. (2011). Effect of hepatic ischemia reperfusion injury on the function of P-Glycoprotein in transporting Rhodamine 123. 62nd Annual Meeting of the American Association for the Study of Liver Diseases, San Francisco, CA, United States, 04-08 November 2011.
Roberts, D. M., Roberts, M. S., Liu, X., Roberts, J. A., Lipman, J. and Bellomo, R. (2010). Clearance of antibiotics by high and low intensity continuous renal replacement therapy in critically ill patients. ESICM 2010: 23rd Annual Meeting of the European Society of Intensive Care Medicine, Barcelona, Spain, 9-13 October, 2010. Heidelberg, Germany: Springer. doi: 10.1007/s00134-010-1999-x
Roberts, D., Roberts, M., Liu, X., Roberts, J., Lipman, J. and Bellomo, R. (2010). Clearance of antibiotics by high and low intensity continuous renal replacement therapy in critically ill patients. ANZSN 2010: 46th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth, WA, Australia, 12-15 September 2010. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2010.01377_1.x
Sangthongpitag, K., Wang, H., Yeo, P., Liu, X., Goh, E., New, L., Zeng, P., Wu, X., Hu, C. and Ethirajulu, K. (2006). ADME and PK/PD attributes of SB939, a potent orally active HDAC inhibitor. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/S1359-6349(06)70172-0