Dr Andrew Lai
Research Fellow
UQ Centre for Clinical Research
Book Chapters
Palma, Carlos, Jellins, Jessica, Lai, Andrew, Salas, Alexis, Campos, America, Sharma, Shayna, Duncombe, Gregory, Hyett, Jon and Salomon, Carlos (2021). Extracellular vesicles and preeclampsia: current knowledge and future research directions. New frontiers: extracellular vesicles. (pp. 455-482) Cham, Switzerland: Springer. doi: 10.1007/978-3-030-67171-6_18
Sharma, Shayna, Alharbi, Mona, Lai, Andrew, Kobayashi, Miharu, Kline, Richard, Wade, Katrina, Rice, Gregory E. and Salomon, Carlos (2017). Cross‐talk between hypoxia and the tumour via exosomes. Hypoxia and human diseases. (pp. 365-381) edited by Jing Zheng and Chi Zhou. Rijeka, Croatia: Intech. doi: 10.5772/65688
Journal Articles
Lai, Andrew, Palma, Carlos, Salas, Alexis, Carrion, Flavio and Salomon, Carlos (2022). Targeted mass spectrometry-based proteomics method to quantify placental extracellular vesicles. Methods in Molecular Biology, 2504, 79-89. doi: 10.1007/978-1-0716-2341-1_6
Nair, Soumyalekshmi, Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Kalita de Croft, Priyakshi, Ormazabal, Valeska, Palma, Carlos, Diaz, Emilio, McCarthy, Elizabeth A., Shub, Alexis, Miranda, Jezid, Gratacós, Eduard, Crispi, Fátima, Duncombe, Gregory, Lappas, Martha, McIntyre, H. David, Rice, Gregory and Salomon, Carlos (2021). Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus. Journal of Translational Medicine, 19 (1) 360, 1-17. doi: 10.1186/s12967-021-02999-9
Alharbi, Mona, Lai, Andrew, Sharma, Shayna, Kalita-De Croft, Priyakshi, Godbole, Nihar, Campos, America, Guanzon, Dominic, Salas-Burgos, Alexis, Carrion, Flavio, Zuñiga, Felipe A., Perrin, Lewis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Hooper, John D., Rice, Gregory E. and Salomon, Carlos (2021). Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence. Cancers, 13 (14) 3388, 3388. doi: 10.3390/cancers13143388
Robinson, Harley, Ruelcke, Jayde E., Lewis, Amanda, Bond, Charles S., Fox, Archa H., Bharti, Vandhana, Wani, Shivangi, Cloonan, Nicole, Lai, Andrew, Margolin, David, Li, Li, Salomon, Carlos, Richards, Renée S., Farrell, Aine, Gardiner, Robert A., Parton, Robert G., Cristino, Alexandre S. and Hill, Michelle M. (2021). Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer. Clinical and Translational Medicine, 11 (4) e381, e381. doi: 10.1002/ctm2.381
Nguyen-Ngo, Caitlyn, Salomon, Carlos, Lai, Andrew, Willcox, Jane C. and Lappas, Martha (2020). Anti-inflammatory effects of gallic acid in human gestational tissues in vitro. Reproduction, 160 (4), 561-578. doi: 10.1530/rep-20-0249
Alharbi, Mona, Sharma, Shayna, Guanzon, Dominic, Lai, Andrew, Zuñiga, Felipe, Shiddiky, Muhammad J.A., Yamauchi, Yusuke, Salas-Burgos, Alexis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Perrin, Lewis, Hooper, John D. and Salomon, Carlos (2020). miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 28 102207, 102207. doi: 10.1016/j.nano.2020.102207
Han, Pingping, Lai, Andrew, Salomon, Carlos and Ivanovski, Sašo (2020). Detection of Salivary Small Extracellular Vesicles Associated Inflammatory Cytokines Gene Methylation in Gingivitis. International Journal of Molecular Sciences, 21 (15) 5273, 5273-17. doi: 10.3390/ijms21155273
Menon, Ramkumar, Debnath, Chirantan, Lai, Andrew, Guanzon, Dominic, Bhatnagar, Shinjini, Kshetrapal, Pallavi, Sheller-Miller, Samantha, Salomon, Carlos and The Garbh-Ini Study team (2020). Protein profile changes in circulating placental extracellular vesicles in term and preterm births: a longitudinal study. Endocrinology, 161 (4) bqaa009. doi: 10.1210/endocr/bqaa009
Dutta, Suchismita, Lai, Andrew, Scholz-Romero, Katherin, Shiddiky, Muhammad J. A., Yamauchi, Yusuke, Mishra, Jay S., Rice, Gregory E., Hyett, Jon, Kumar, Sathish and Salomon, Carlos (2020). Hypoxia-induced small extracellular vesicle proteins regulate proinflammatory cytokines and systemic blood pressure in pregnant rats. Clinical Science, 134 (6), 593-607. doi: 10.1042/cs20191155
Nguyen-Ngo, Caitlyn, Salomon, Carlos, Quak, Stephanie, Lai, Andrew, Willcox, Jane C and Lappas, Martha (2020). Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes. Clinical Science, 134 (6), 571-592. doi: 10.1042/cs20191099
James-Allan, Laura B., Rosario, Frederick J., Barner, Kelsey, Lai, Andrew, Guanzon, Dominic, McIntyre, H. David, Lappas, Martha, Powell, Theresa L., Salomon, Carlos and Jansson, Thomas (2020). Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes. FASEB Journal, 34 (4) fj.201902522RR, 5724-5739. doi: 10.1096/fj.201902522RR
Tapia-Castillo, Alejandra, Guanzon, Dominic, Palma, Carlos, Lai, Andrew, Barros, Eric, Allende, Fidel, Vecchiola, Andrea, Fardella, Carlos E., Salomón, Carlos and Carvajal, Cristian A. (2019). Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess. Journal of Translational Medicine, 17 (1) 392, 392. doi: 10.1186/s12967-019-02143-8
Alharbi, Mona, Lai, Andrew, Guanzon, Dominic, Palma, Carlos, Zuñiga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D and Salomon, Carlos (2019). Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells. Clinical Science, 133 (13), CS20190082-1419. doi: 10.1042/cs20190082
Menon, Ramkumar, Dixon, Christopher Luke, Sheller-Miller, Samantha, Fortunato, Stephen J., Saade, George R., Palma, Carlos, Lai, Andrew, Guanzon, Dominic and Salomon, Carlos (2019). Quantitative proteomics by SWATH-MS of maternal plasma exosomes determine pathways associated with term and preterm birth. Endocrinology, 160 (3), 639-650. doi: 10.1210/en.2018-00820
Jayabalan, Nanthini, Lai, Andrew, Nair, Soumyalekshmi, Guanzon, Dominic, Scholz-Romero, Katherin, Palma, Carlos, McIntyre, Harold David, Lappas, Martha and Salomon, Carlos (2019). Quantitative proteomics by SWATH-MS suggest an association between circulating exosomes and maternal metabolic changes in gestational diabetes mellitus. Proteomics, 19 (1-2) 1800164, e1800164. doi: 10.1002/pmic.201800164
Jayabalan, Nanthini, Lai, Andrew, Ormazabal, Valeska, Adam, Stefanie, Guanzon, Dominic, Palma, Carlos, Scholz-Romero, Katherin, Lim, Ratana, Jansson, Thomas, McIntyre, Harold David, Lappas, Martha and Salomon, Carlos (2018). Adipose tissue exosomal proteomic profile reveals a role on placenta glucose metabolism in gestational diabetes mellitus. The Journal of Clinical Endocrinology & Metabolism, 104 (5) jcem-201801599, 1735-1752. doi: 10.1210/jc.2018-01599
Alharbi, Mona, Zuñiga, Felipe, Elfeky, Omar, Guanzon, Dominic, Lai, Andrew, Rice, Gregory E., Perrin, Lewis, Hooper, John and Salomon, Carlos (2018). The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer. Endocrine-Related Cancer, 25 (12), R663-R685. doi: 10.1530/erc-18-0019
Menon, Ramkumar, Debnath, Chirantan, Lai, Andrew, Guanzon, Dominic, Bhatnagar, Shinjini, Pallavi, S. K., Sheller-Miller, Samantha, The Garbhini Study team and Salomon, Carlos (2018). Circulating exosomal miRNA profile during term and preterm birth pregnancies - a longitudinal study. Endocrinology, 160 (2), 249-275. doi: 10.1210/en.2018-00836
Sharma, Shayna, Alharbi, Mona, Kobayashi, Miharu, Lai, Andrew, Guanzon, Dominic, Zuñiga, Felipe, Ormazabal, Valeska, Palma, Carlos, Scholz-Romero, Katherin, Rice, Gregory E., Hooper, John D. and Salomon, Carlos (2018). Proteomic analysis of exosomes reveals an association between cell invasiveness and exosomal bioactivity on endothelial and mesenchymal cell migration. Clinical Science, 132 (18), 2029-2044. doi: 10.1042/CS20180425
Dixon, C. Luke, Sheller-Miller, Samantha, Saade, George R., Fortunato, Stephen J., Lai, Andrew, Palma, Carlos, Guazon, Dominic, Salomon, Carlos and Menon, Ramkumar (2018). Amniotic fluid exosome proteomic profile exhibits unique pathways of term and preterm labor. Endocrinology, 159 (5), 2229-2240. doi: 10.1210/en.2018-00073
Miranda, Jezid, Paules, Cristina, Nair, Soumyalekshmi, Lai, Andrew, Palma, Carlos, Scholz-Romero, Katherin, Rice, Gregory E., Gratacos, Eduard, Crispi, Fatima and Salomon, Carlos (2018). Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth. Placenta, 64, 34-43. doi: 10.1016/j.placenta.2018.02.006
Lai, Andrew, Elfeky, Omar, Rice, Gregory E. and Salomon, Carlos (2017). Optimized Specific Isolation of Placenta-Derived Exosomes from Maternal Circulation. Methods in Molecular Biology , 1710, 131-138. doi: 10.1007/978-1-4939-7498-6_10
Lai, Andrew, Kinhal, Vyjayanthi, Nuzhat, Zarin, Menon, Ramkumar, Rice, Gregory E. and Salomon, Carlos (2017). Proteomics Method to Identification of Protein Profiles in Exosomes. Methods in Molecular Biology, 1710, 139-153. doi: 10.1007/978-1-4939-7498-6_11
Adam, Stefanie, Elfeky, Omar, Kinhal, Vyjayanthi, Dutta, Suchismita, Lai, Andrew, Jayabalan, Nanthini, Nuzhat, Zarin, Palma, Carlos, Rice, Gregory E. and Salomon, Carlos (2017). Fetal-maternal communication via extracellular vesicles - implications for complications of pregnancies. Placenta, 54, 83-88. doi: 10.1016/j.placenta.2016.12.001
Truong, Grace, Guanzon, Dominic, Kinhal, Vyjayanthi, Elfeky, Omar, Lai, Andrew, Longo, Sherri, Nuzhat, Zarin, Palma, Carlos, Scholz-Romero, Katherin, Menon, Ramkumar, Mol, Ben W., Rice, Gregory E. and Salomon, Carlos (2017). Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells-liquid biopsies for monitoring complications of pregnancy. PLoS ONE, 12 (3) e0174514, e0174514. doi: 10.1371/journal.pone.0174514
Elfeky, Omar, Longo, Sherri, Lai, Andrew, Rice, Gregory E. and Salomon, Carlos (2017). Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation. Placenta, 50, 60-69. doi: 10.1016/j.placenta.2016.12.020
Conference Papers
Alharbi, Mona G., Lai, Andrew, Zuniga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D. and Salomon, Carlos (2019). Ovarian cancer cell invasiveness regulates their exosomes which induces oncogenic potential and cancer progression in vivo. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
Sharma, Shayna, Lai, Andrew, Guanzon, Dominic, Morgan, Terry, Perrin, Lewis C., Hooper, John D. and Salomon, Carlos (2019). Circulating exosomal miRNAs from women with ovarian cancer for early detection and real-time monitoring of disease progression. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, 12-16 March 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
Scholz-Romero, Katherin, Lai, Andrew, Duncombe, Gregory, Rice, Gregory and Salomon, Carlos (2019). Cytokines profile in different populations of extracellular vesicles during the first trimester of pregnancy. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, Japan, 21-24 September 2018. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2019.06.079
Nair, Soumyalekshmi, Ormazabal, Valeska, Ramirez, Macarena, Lai, Andrew, Scholz Romero, Katherin, McIntyre, David, Diaz, Emilio, Zuniga, Felipe, Lappas, Martha and Salomon, Carlos (2019). Protein analysis in skeletal muscle from gestational diabetes mellitus and their association with insulin signalling during pregnancy. Meeting of the International Federation of Placenta Associations (IFPA), Tokyo, Japan, 21-24 September, 2018. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2019.06.307
Nair, Soumyalekshmi S., Lai, Andrew, McIntyre, David, Lappas, Martha and Salomon, Carlos (2019). Quantitative proteomics using SWATH in skeletal muscle and placenta from gestational diabetes mellitus reveals novel alterations associated with glucose metabolism and insulin sensitivity during pregnancy. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
Dutta, Suchismita, Palma, Carlos, Lai, Andrew, Kumar, Sathish, Hyett, Jonathan, Nakahara, Angela, Longo, Sherri and Salomon, Carlos (2019). Low dose aspirin modulates the proteomic content of placental trophoblast derived exosomes at different oxygen tensions. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
Tribe, Rachel M., Jenkins, Holly, Palma, Carlos, Lai, Andrew, Guanzon, Dominic, Hezelgrave, Natasha L., Shennan, Andrew H. and Salomon, Carlos (2019). Exosomal protein and miRNA analysis in cervico-vaginal fluid at early gestation from term and preterm pregnancies. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, 12 - 16 March 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
Dixon, Christopher L., Lai, Andrew, Palma, Carlos, Salomon, Carlos and Menon, Ramkumar (2018). Proteomic profile of amniotic fluid exosomes in spontaneous preterm birth. 38th Annual Meeting and Pregnancy Meeting of the Society for Maternal Fetal Medicine, Dallas, TX, United States, 29 January - 3 February 2018. Philadelphia, PA, United States: Mosby. doi: 10.1016/j.ajog.2017.11.132
Nair, Soumyalekshmi, Jayabalan, Nanthini, Guanzon, Dominic, Lai, Andrew, Scholz-Romero, Katherin, Elfeky, Omar, Zuniga, Felipe, Diaz, Emilio, McIntyre, David, Rice, Gregory E., Lappas, Martha and Salomon, Carlos (2018). Interactions between Placental Exosomes and Skeletal Muscle Implication in Cell Metabolism in Gestational Diabetes Mellitus. 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), San Diego, CA, United States, 6-10 March 2018. Thousand Oaks, CA, United States: Sage.
Alharbi, Mona, Lai, Andrew, Guanzon, Dominic, Sharma, Shayna, Palma, Carlos, Zuniga, Felipe, Rice, Gregory E., Perrin, Lewis, Hooper, John D. and Salomon, Carlos (2018). Integrative Analysis of Multi-Omics Exosomal Data for Identifying Multi-Markers for Susceptibility to Chemotherapy in Ovarian Cancer. 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), San Diego Ca United States, 6-10 March 2018. Thousand Oaks, CA United States: Sage.
Elfeky, Omar, Longo, Sherri, Lai, Andrew, Duncombe, Gregory, Rice, Gregory E. and Salomon, Carlos (2017). Maternal BMI regulates the exosomal bioactivity on cytokine release from endothelial cells. 64th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Orlando, FL, United States, 15-18 March 2017. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719117699773
Sharma, Shayna, Scholz-Romero, Katherin, Kline, Richard, Wade, Katrina, Estes, Jacob, Palma, Carlos, Guanzon, Dominic, Lai, Andrew, Hooper, John, Rice, Gregory E. and Salomon, Carlos (2017). Exosomal content in the plasma of patients with ovarian cancer reflect tumor state and induce the epithelial to mesenchymal transition in target cells. 64th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Orlando, FL, United States, 15-18 March 2017. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719117699773
Jayabalan, Nanthini, Guanzon, Dominic, Lai, Andrew, McIntyre, David, Jansson, Thomas, Rice, Gregory E., Lappas, Martha and Salomon, Carlos (2017). Characterisation of adipose tissue-derived exosomes in normal and diabetes mellitus pregnancies: Potential role of exosomal miRNAs. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester, United Kingdom, Aug 30-Sep 2 2017. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2017.07.133
Lai, Andrew, Rice, Gregory and Salomon, Carlos (2017). Specific isolation of placenta-derived exosomes from maternal circulation. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester England, Aug 30-Sep 2 2017. London, United Kingdom: Elsevier . doi: 10.1016/j.placenta.2017.07.242
Adam, Stefanie, Guanzon, Dominic, Scholz-Romero, Katherin, Elfeky, Omar, Longo, Sherri, Lai, Andrew, Duncombe, Gregory, Rice, Gregory E., Lappas, Martha and Salomon, Carlos (2017). Next-Generation miRNA Sequencing Reveals That Exosomes Present in Maternal Circulation of Gestational Diabetes Pregnancies Regulate Glucose Metabolism in Placental Cells. 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Orlando, FL, United States, 15-18 March 2017. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719117699773
Guanzon, Dominic, Jayabalan, Nanthini, Palma, Carlos, Nair, Soumyalekshmi, Scholz-Romero, Katherin, Kinhal, Vyjayanthi, Lai, Andrew, McIntyre, David, Jansson, Thomas, Rice, Gregory, Lappas, Martha and Salomon, Carlos (2017). Exosomes present in circulation of women with gestational diabetes mellitus carry a specific set of microRNAs associated with insulin resistant. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester, United Kingdom, Aug 30-Sep 2 2017. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2017.07.134
Miranda, Jezid, Paules, Cristina, Crispi, Fatima, Gratacos, Eduard, Kinhal, Vyjayanthi, Lai, Andrew, Palma, Carlos and Salomon, Carlos (2017). Pregnancy-Associated Exosomes Changes in Pregnancies Complicated by Small-for-Gestational-Age (SGA) Neonates and Intrauterine Growth Restriction (IUGR). 64th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Orlando, FL, United States, 15-18 March 2017. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719117699773